Results 91 to 100 of about 58,443,833 (259)

Sawan: exploring the knowledge and wisdom of Javanese traditional healing practices

open access: yesCogent Arts & Humanities
In the current digital era, despite technological advancements and increased access to education, there remains a significant population in Indonesia that believes in traditional healing practices associated with ‘mystical’ illnesses. One such illness is
Suyami Suyami   +9 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

open access: yesFEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik   +5 more
wiley   +1 more source

Recommendations on intellectual property and knowledge transfer for charity-funded research [PDF]

open access: yes, 2018
A core belief of the HRCI is that charity-funded research should be used for public good; for the benefit of patients and to improve the nation’s health.
Medical Research Charities Group
core  

The Impact of Psoriasis and Atopic Dermatitis on Quality of Life: A Literature Research on Biomarkers. [PDF]

open access: yesLife (Basel), 2022
Balato A   +7 more
europepmc   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

open access: yesFEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens   +8 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

Volunteering for All: national framework - literature review [PDF]

open access: yes, 2019
This report outlines a systematic review of the research literature on volunteering. The purpose of this review is to inform the development of a Volunteering Outcomes Framework to support the critical role that volunteering plays in Scotland for ...
Rutherford, Alasdair   +3 more
core  

Investigating transcription factor dynamics in health and disease using FRAP

open access: yesFEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj   +3 more
wiley   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

open access: yesFEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang   +4 more
wiley   +1 more source

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