Results 21 to 30 of about 3,203 (227)

Emended Description ofLitomosoides molossi(Nematoda: Onchocercidae) and First Records ofLitomosoidesSpecies Parasitizing Argentinean Bats [PDF]

Journal of Parasitology, 2016
(Uploaded by Plazi for the Bat Literature Project) During a long-term study on biodiversity of bats in the Yungas and Entre Rı´ os provinces, 1,304 specimens of bats included in the families Noctilionidae, Phyllostomidae, Vespertilionidae, and Molossidae were collected and checked for filarioids.
Mirna C. Oviedo, Juliana Notarnicola, María Daniela Miotti, Lucía E. Claps   +3 more
openalex   +4 more sources

Repeated sensitization of mice with microfilariae of Litomosoides sigmodontis induces pulmonary eosinophilia in an IL-33-dependent manner. [PDF]

PLoS Pathogens
BackgroundEosinophilia is a hallmark of helminth infections and eosinophils are essential in the protective immune responses against helminths. Nevertheless, the distinct role of eosinophils during parasitic filarial infection, allergy and autoimmune ...
Benjamin Lenz, Alexandra Ehrens, Jesuthas Ajendra, Frederic Risch, Joséphine Gal, Anna-Lena Neumann, Julia J Reichwald, Wiebke Strutz, Henry J McSorley, Coralie Martin, Achim Hoerauf, Marc P Hübner   +11 more
doaj   +2 more sources

Escalation of Germinal Center Responses in Chronic Litomosoides sigmodontis Filarial Infection. [PDF]

Eur J Immunol
T follicular helper (TFH) cells provide essential help to B cells in germinal centers (GCs). TFH and GC B cell responses are long‐lasting in draining mediastinal lymph nodes of Litomosoides sigmodontis‐infected BALB/c mice, a rodent model of filarial infection. ABSTRACT T follicular helper (TFH) cells are the primary CD4+ T helper cell subset providing
Steffen T, Ajendra J, Koschel M, Palmen A, Wegner H, Risch F, Bach L, Ritter M, Hübner MP, Baumjohann D.   +9 more
europepmc   +2 more sources

Litomosoides sigmodontis microfilariae-induced eosinophil ETosis is dependent on the canonical inflammasome pathway

Cell Reports
Summary: Granulocytes exert several effector mechanisms, including the release of DNA traps during ETosis. While bacteria-induced ETosis has been linked to the non-canonical inflammasome pathway, the role of the inflammasome activation during ETosis in ...
Alexandra Ehrens, Benjamin Lenz, Celia Nieto-Pérez, Eicke Latz, Florian I. Schmidt, Achim Hoerauf, Marc P. Hübner   +6 more
doaj   +2 more sources

PD-L2 Inhibits Protective Immunity, Th2 Cell Functional Quality, and GATA-3 Expression During Filarial Nematode Infection. [PDF]

Eur J Immunol
During filarial nematode infection with Litomosoides sigmodontis, PD‐L2 down‐regulates Th2 cell expression of GATA‐3 and Th2 cytokines and enables parasite survival. Concurrently, B cells suppress protective immunity through a mechanism that does not involve PD‐L2.
Knipper JA, Campbell SM, Allen JE, Taylor MD.   +3 more
europepmc   +2 more sources

Isoenzymatic diagnosis ofLitomosoides galizaiandLitomosoides sigmodontis [PDF]

Annales de Parasitologie Humaine et Comparée, 1993
The morphological diagnosis of the two species, Litomosoides sigmodontis Chandler, 1931 and L. galizai Bain, Petit et Diagne, 1989 is confirmed by the isoenzymatic analysis. In L. galizai, the mannose-phosphate isomerase and the glucose-phosphate isomerase migrate much faster and therefore further than in L.
Pierre Maréchal, Jacques Cabaret, G. Petit, Mamadou Diagne, N. Gasnier, O. Bain   +5 more
openalex   +3 more sources

The immune response of inbred laboratory mice to Litomosoides sigmodontis: A route to discovery in myeloid cell biology [PDF]

Parasite Immunology, Volume 42, Issue 7, July 2020., 2020
Abstract Litomosoides sigmodontis is the only filarial nematode where the full life cycle, from larval delivery to the skin through to circulating microfilaria, can be completed in immunocompetent laboratory mice. It is thus an invaluable tool for the study of filariasis.
Conor M. Finlay, Judith E. Allen
openalex   +2 more sources

Deletion of parasite immune modulatory sequences combined with immune activating signals enhances vaccine mediated protection against filarial nematodes [PDF]

, 2012
<p>Background: Filarial nematodes are tissue-dwelling parasites that can be killed by Th2-driven immune effectors, but that have evolved to withstand immune attack and establish chronic infections by suppressing host immunity. As a consequence, the
AB Fredriksen, AB Pedersen, AE O'Connell, AE Schwab, B de Andres, B Manoury, BL Makepeace, BW Li, C Klotz, C Martin, C Martin, D Abraham, D Abraham, D Horst, D Knox, David W. Taylor, DH Barouch, DL Redmond, E Maraskovsky, G Ahlen, G Nchinda, GT Joseph, HA Farid, HongLin Luo, J Gardon, J Murray, JE Allen, JE Allen, JJ Donnelly, JP Hewitson, Judith E. Allen, KJ Fairlie-Clarke, KJ Ishii, LM Mir, LM Mir, LvG Jørgensen, MD Taylor, MD Taylor, MY Osei-Atweneboana, N Gomez-Escobar, Nick Gray, O Golden, PJ Hotez, R Ihaka, RM Maizels, RT Rwegoshora, S Babayan, S Frontier, S Mendez, S Ramachandran, S Thirugnanam, SA Babayan, SA Babayan, SB Anand, SB Anand, SB Anand, Simon A. Babayan, SM Sumida, Stephen John Davies, W Harnett, WF Gregory, WF Gregory, Y Dash, Y Wu   +63 more
core   +14 more sources

CD154 Restricts Helminth-Induced Macrophage Polarisation and Proliferation While Promoting Tissue Residence. [PDF]

Parasite Immunol
ABSTRACT CD154 (CD40L) is of central importance in effector responses mediated by classically activated macrophages. However, there is limited information on the impact of CD154 on macrophage responses in type 2 contexts, characterised by IL‐4‐induced polarisation and proliferation.
Suárez-Martins M, Parkinson J, Zhang L, Chan B, Baldwin G, Dodd RJ, Finlay CM, Papotto P, Allen JE, Díaz Á.   +9 more
europepmc   +2 more sources

Repurposing Oxfendazole for Onchocerciasis: Population Pharmacokinetics of a Tablet Formulation in Healthy African Adults. [PDF]

CPT Pharmacometrics Syst Pharmacol
ABSTRACT Global efforts to eliminate onchocerciasis are hampered by the lack of a macrofilaricidal drug capable of killing adult parasites. Oxfendazole, a veterinary anthelminthic, exhibits macrofilaricidal activity and holds promise to shorten treatment durations.
Assmus F, Adehin A, Hoglund RM, Nyaulingo G, Mbarak H, Jongo S, Ackermann E, Reus E, Keiser J, Rocha FBDS, Specht S, Scandale I, Tarning J.   +12 more
europepmc   +2 more sources