Results 31 to 40 of about 3,203 (227)

Editorial: Host immune response and protective immune responses during filarial infections [PDF]

Frontiers in Immunology, 2022
Manuel Ritter, Marc P. Hübner, Marc P. Hübner   +2 more
doaj   +2 more sources

Programmed cell death pathways as targets for developing antifilarial drugs: Lessons from the recent findings

Journal of Cellular and Molecular Medicine, Volume 27, Issue 19, Page 2819-2840, October 2023., 2023
Abstract More than half a century has passed since the introduction of the National Filariasis Control Program; however, as of 2023, lymphatic filariasis (LF) still prevails globally, particularly in the tropical and subtropical regions, posing a substantial challenge to the objective of worldwide elimination.
Nabarun Chandra Das, Pritha Chakraborty, Samapika Nandy, Abhijit Dey, Tabarak Malik, Suprabhat Mukherjee   +5 more
wiley   +1 more source

Glycosphingolipids in human parasites

FEBS Open Bio, Volume 13, Issue 9, Page 1625-1635, September 2023., 2023
The parasites that infect humans and animals include protozoans and helminths (worms). Their secretions and cellular membranes contain complex glycomolecules including glycoproteins and glycolipids. A class of glycolipids shared between humans and parasites are the glycosphingolipids (GSLs) containing a lipid (ceramide) linked to a glycan ...
Richard D. Cummings
wiley   +1 more source

Eosinophil: An innate immune cell with anti‐filarial vaccine and biomarker potential

Health Science Reports, Volume 6, Issue 6, June 2023., 2023
Abstract Background Filarial infections continue to pose a great challenge in endemic countries. One of the central goals in the fight against human filarial infections is the development of strategies that will lead to the inhibition of microfilariae (mf) transmission.
Alexander Kwarteng, Caleb Mensah, Priscilla Osei‐Poku   +2 more
wiley   +1 more source

STUDIES ON THE METABOLISM OF THE FILARIAL WORM, LITOMOSOIDES CARINII [PDF]

Journal of Experimental Medicine, 1949
The filarial worm, Litomosoides carinii, has a high rate of aerobic and anaerobic glucose metabolism. Aerobically 30 to 45 per cent of the glucose utilized was converted to lactic acid, 25 to 35 per cent to acetic acid, and 10 to 20 per cent to a polysaccharide.
Ernest Bueding
openalex   +4 more sources

Filarial nematode phenotypic screening cascade to identify compounds with anti-parasitic activity for drug discovery optimization

International Journal for Parasitology: Drugs and Drug Resistance, 2022
Filarial diseases, including lymphatic filariasis and onchocerciasis, are considered among the most devastating of all tropical diseases, affecting over 86 million people worldwide. To control and more rapidly eliminate onchocerciasis requires treatments
Natalie Hawryluk, Li Zhiru, Clotilde Carlow, Suzanne Gokool, Simon Townson, Tamara Kreiss, Agnieszka Chojnowski, Monika Prorok, John Siekierka, Alexandra Ehrens, Marianne Koschel, Nathaly Lhermitte-Vallarino, Coralie Martin, Achim Hoerauf, Geraldine Hernandez, Stacie Canan, Vikram Khetani, Jerome Zeldis, Sabine Specht, Marc P. Hübner, Ivan Scandale   +20 more
doaj   +1 more source

Diet‐microbiota crosstalk and immunity to helminth infection

Parasite Immunology, Volume 45, Issue 4, April 2023., 2023
Abstract Helminths are large multicellular parasites responsible for widespread chronic disease in humans and animals. Intestinal helminths live in close proximity with the host gut microbiota and mucosal immune network, resulting in reciprocal interactions that closely influence the course of infections.
Laura J. Myhill, Andrew R. Williams
wiley   +1 more source

Hookworm infections: Reappraising the evidence for a role of neutrophils in light of NETosis

Parasite Immunology, Volume 44, Issue 6, June 2022., 2022
Abstract In Hookworm infection, neutrophils have long had the image of the villain, being recruited to the site of larval migration because of damage but participating themselves in tissue injury. With recent developments in neutrophil biology, there is an increasing body of evidence for the role of neutrophils as effector cells in hookworm immunity ...
Rory Doolan, Tiffany Bouchery
wiley   +1 more source

Evaluating Helminth to Treat Type 2 Diabetes – A Review [PDF]

WMJ (Warmadewa Medical Journal), 2019
Type 2 diabetes (T2D) is characterized by lacking production of insulin and impaired insulin sensitivity. Despite the availability of antidiabetic drugs on the market, exploration of new therapeutic drugs for treating T2D from nature remains necessary ...
Made Dharmesti Wijaya, Anak Agung Gede Indraningrat   +1 more
doaj   +1 more source

Immunomodulation of COVID‐19 severity by helminth co‐infection: Implications for COVID‐19 vaccine efficacy

Immunity, Inflammation and Disease, Volume 10, Issue 3, March 2022., 2022
Helminth co‐infection could modulate the severity of COVID‐19. Not all parasites will have immunomodulatory properties. Lessons from respiratory viruses coinfected with helminth have been shown reduced vaccine efficacy. Helminth co‐infection and antihelminthic therapy could reduce and enhance the efficacy of COVID‐19 vaccines, respectively.
Yibeltal Akelew, Henok Andualem, Endris Ebrahim, Aytenew Atnaf, Wasihun Hailemichael   +4 more
wiley   +1 more source