Results 61 to 70 of about 3,203 (227)

Lipid profiling of the filarial nematodes Onchocerca volvulus, Onchocerca ochengi and Litomosoides sigmodontis reveals the accumulation of nematode-specific ether phospholipids in the host [PDF]

, 2017
Onchocerciasis, a neglected tropical disease prevalent in western and central Africa, is a major health problem and has been targeted for elimination. The causative agent for this disease is the human parasite Onchocerca volvulus.
Doermann, Peter, Hoerauf, Achim, Makepeace, Benjamin L, Peisker, Helga, Pfarr, Kenneth, Tanya, Vincent N, Wewer, Vera   +6 more
core   +1 more source

Regulation of immunity and allergy by helminth parasites

Allergy, Volume 75, Issue 3, Page 524-534, March 2020., 2020
Abstract There is increasing interest in helminth parasite modulation of the immune system, both from the fundamental perspective of the “arms race” between host and parasite, and equally importantly, to understand if parasites offer new pathways to abate and control untoward immune responses in humans.
Rick M. Maizels
wiley   +1 more source

Inherent biomechanical traits enable infective filariae to disseminate through collecting lymphatic vessels

Nature Communications, 2019
Stimuli affecting migration of filaria in host tissues are unclear. Using in situ imaging, Kilarski et al. here show that universal adaptations of nematodes allow Litomosoides sigmodontis infective larvae to mechanically break into pre-collecting ...
Witold W. Kilarski, Coralie Martin, Marco Pisano, Odile Bain, Simon A Babayan, Melody A. Swartz   +5 more
doaj   +1 more source

A target repurposing approach identifies N-myristoyltransferase as a new candidate drug target in filarial nematodes [PDF]

, 2014
Myristoylation is a lipid modification involving the addition of a 14-carbon unsaturated fatty acid, myristic acid, to the N-terminal glycine of a subset of proteins, a modification that promotes their binding to cell membranes for varied biological ...
Carlow, Clotilde K. S., Chapman, Melissa S., Galvin, Brendan D., Li, Zhiru, Pollastri, Michael P., Poole, Catherine B., Villemaine, Estelle, Wyatt, Paul G.   +7 more
core   +4 more sources

Litomosa chiropterorum Ortlepp, 1932 (Nematoda: Filarioidea) from a South African miniopterid: redescription, Wolbachia screening and phylogenetic relationships with Litomosoides

Parasite, 2009
69 Miniopterus natalensis, type host of the onchocercid Litomosa chiropterorum, were collected in caves in the Western Province and Gauteng Province, South Africa. The prevalence of these filariae was about 50%.
Junker K., Barbuto M., Casiraghi M., Martin C., Uni S., Boomker J., Bain O.   +6 more
doaj   +1 more source

Of mice, cattle, and humans: the immunology and treatment of river blindness.

PLoS Neglected Tropical Diseases, 2008
River blindness is a seriously debilitating disease caused by the filarial parasite Onchocerca volvulus, which infects millions in Africa as well as in South and Central America. Research has been hampered by a lack of good animal models, as the parasite
Judith E Allen, Ohene Adjei, Odile Bain, Achim Hoerauf, Wolfgang H Hoffmann, Benjamin L Makepeace, Hartwig Schulz-Key, Vincent N Tanya, Alexander J Trees, Samuel Wanji, David W Taylor   +10 more
doaj   +1 more source

Effects of Levamisole on Glycogen Phosphorylase Activity of Litomosoides carinii

The Journal of Parasitology, 1982
The antinematodal agent, levamisole, has been reported to initiate a rapid stimulatory paralysis of adult filariids upon in vitro incubation (Wang and Saz, 1974, J. Parasitol. 60: 316-321). This was followed by slower flaccid paralysis. Although the primary effect appears to be on the neuromusculature, levamisole also affects other systems in ...
Norman F. Nelson, Howard J. Saz
openalex   +3 more sources

The therapeutic efficacy and macrofilaricidal activity of doxycycline for the treatment of river blindness [PDF]

, 2014
Background. Onchocerca volvulus and lymphatic filariae, causing river blindness and elephantiasis, depend on endosymbiotic Wolbachia bacteria for growth, development, fertility, and survival.
Achim Hoerauf, Agwuh, Basáñez, Basáñez, Bosshardt, Cattamanchi, Chib, Churcher, de Andrade, Debrah, Duke, Duke, Gardon, Gelman, Hoerauf, Hoerauf, Hoerauf, Hoerauf, Hoerauf, Hoerauf, Hoerauf, Mand, Mark J. Taylor, Martin Walker, María-Gloria Basáñez, Norton, Osei-Atweneboana, Plaisier, Plaisier, Roberts, Sabine Specht, Specht, Tamarozzi, Taylor, Taylor, Taylor, Taylor, Taylor, Thomas S. Churcher, van Rie, Wanji, Wearing, World Health Organization, Xia   +43 more
core   +2 more sources

Helminths as architects of trained tolerance: implications for human health

Clinical &Translational Immunology, Volume 15, Issue 3, 2026.
Abstract Helminths infect nearly 2 billion people worldwide and are a major cause of chronic morbidity in low‐resource regions. Unlike bacterial and viral pathogens that elicit protective memory, helminths actively remodel host immunity to enable their years‐long persistence and reinfection.
Quinn Moroz, Jorge Lucas Nascimento Souza, Neima Briggs   +2 more
wiley   +1 more source

Exploring the immunology of parasitism--from surface antigens to the hygiene hypothesis [PDF]

, 2009
Helminth immunology is a field which has changed beyond recognition in the past 30 years, transformed not only by new technologies from cDNA cloning to flow cytometry, but also conceptually as our definition of host immune pathways has matured.
Maizels, R M
core   +1 more source