Results 41 to 50 of about 122,239 (253)

DEVELOPMENT OF GLACIERS OF MOUNT ELBRUS AFTER THE LITTLE ICE AGE

Лëд и снег, 2015
SummaryThe results of remote monitoring of the greatest inEuropemountain glaciation of Elbrus are covered for 120 years by instrumental survey (1887–2007) and lichenometric survey in 1986.
E. A. Zolotarev, E. G. Kharkovets
doaj   +1 more source

Little Ice Age clearly recorded in northern Greenland ice cores [PDF]

Geophysical Research Letters, 1998
Four ice cores drilled in the little investigated area of northern and northeastern Greenland were evaluated for their isotopic (δ18O) and chemical content. From these rather uniform records a stable isotope temperature time series covering the last 500 years has been deduced, which reveals distinct climate cooling during the 17th and the first half of
Fischer, Hubertus, Werner, Martin, Wagenbach, D., Schwager, M., Thorsteinnson, T., Wilhelms, Frank, Kipfstuhl, J., Sommer, S.   +7 more
openaire   +3 more sources

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Volcanism and the Little Ice Age [PDF]

PAGES news, 2008
Udgivelsesdato ...
T. J. Crowley, G. Zielinski, B. Vinther, UDISTI, ROBERTO, K. Kreutz, J. Cole Dai, CASTELLANO, EMILIANO   +6 more
openaire   +2 more sources

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Reduction of glaciers of the South Chuya Range (Altai) since the maximum of the Little Ice Age

Лëд и снег
The extent of glaciation of the South Chuya Range in the LIA and the analysis of its subsequent gradual reduction were assessed. Based on interpretation of Corona, Landsat-7, Sentinel-2, World View-3 satellite images and analysis of field data, the ...
D. A. Ganyushkin, D. V. Bantcev, S. A. Griga, E. S. Derkach, O. V. Ostanin, Yu. A. Gorbunova,, V. A. Rasputina, K. V. Chistyakov   +7 more
doaj   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Monitoring of circulating tumor DNA allows early detection of disease relapse in patients with operable breast cancer

Molecular Oncology, EarlyView.
Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad, Marie Austdal, Oddmund Nordgård, Gunnar Mellgren, Satu Oltedal, Marie L. Austbø, Ylva H. Vignes, Thomas Helland, Kristin Jonsdottir, Tone H. Lende, Emilius A. M. Janssen, Bjørnar Gilje, Kjersti Tjensvoll, PBCB study group, Gunnar Mellgren, Tone Hoel Lende, Anette Heie, Kristin Viste, Anita Røyneberg Alvheim, Emiel AM Janssen, Kristin Jonsdottir, Ann Cathrine Kroksveen, Thomas Helland, Einar Gudlaugsson, Oddmund Nordgård, Satu Oltedal, Kristin Løge Aanestad, Jan Terje Kvaløy, Kirsten Lode, Kari Britt Hagen, Marie Austdal, Ylva H. Vignes, Siri Tungland Sola, Nina Egeland Amundsen, Finn Magnus Eliassen, Emeritus Ernst A Lien   +35 more
wiley   +1 more source

Post-little ice age glacial geomorphology of contrasting topographic settings at Skálafellsjökull, southeast Iceland

Journal of Maps
Glacial geomorphological mapping from the southern margin of Skálafellsjökull, southeast Iceland, depicts a topographically diverse mountainside, influencing glacier dynamics, landform formation and glacier retreat since the Little Ice Age maximum in ...
Sarah Walton, Robert Storrar, Naomi Holmes, Jonathan Bridge, Marek Ewertowski, Aleksandra Tomczyk, Andrew Jones   +6 more
doaj   +1 more source