Results 51 to 60 of about 122,239 (253)
Little Ice Age climate reconstruction from ensemble reanalysis of Alpine glacier fluctuations [PDF]
The Cryosphere, 2014 Mountain glaciers sample a combination of climate fields – temperature, precipitation and radiation – by accumulation and melting of ice. Flow dynamics acts as a transfer function that maps volume changes to a length response of the glacier ...
M. P. Lüthi
doaj +1 more source
Defining the Little Ice Age [PDF]
, 2010 Abstract. The "Little Ice Age" (LIA) is possibly the best-documented climatic anomaly of the past. A wide range of datasets portrays a harsh climate that worsened living conditions, primarily in terms of cooler temperatures, for people across Europe sometime during the last millennium.
Paasche, Ø., Bakke, J.
openaire +2 more sources
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
The Palaeomeander at Vrakuňa, SW Slovakia and the historical Topography of the fording Point (Toll) on Žitný Ostrov Island / Vrakunský paleomeander a historická topografia mýtneho prechodu na Žitný ostrov [PDF]
Studia Historica NitriensiaThe Žitný ostrov Island (Hungarian: Csallóköz, German: Schüttinsel) located in SW Slovakia is separated from the main channel by the Malý Dunaj (Lesser or Little Danube), known as Čalov (Csalló) in the medieval period.
PIŠÚT, Peter +3 more
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Little Ice Age advance and retreat of Glaciar Jorge Montt, Chilean Patagonia [PDF]
Climate of the Past, 2012 Glaciar Jorge Montt (48°20' S/73°30' W), one of the main tidewater glaciers of the Southern Patagonian Icefield (SPI), has experienced the greatest terminal retreat observed in Patagonia during the past century, with a recession of 19.5 km between 1898 ...
A. Rivera +3 more
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Whence the Little Ice Age? [PDF]
Science, 2012 Climate Science In the second half of the past millennium, glaciers advanced and temperatures fell in many regions around the world, although the timings and durations of the cold spells differed widely between regions. Numerous causes for this Little Ice Age have been proposed, including cyclical reductions in solar irradiance, changes in ocean ...
openaire +1 more source
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source
Quaternary, 2019 The Toledo Mountains are a mid-elevation mountain range that separates the Tagus and Guadiana basins in the central area of the Iberian Peninsula. The location of these mountains allows the development of typical Mediterranean vegetation with some ...
Reyes Luelmo-Lautenschlaeger +4 more
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Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source