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Live Attenuated Influenza Vaccine

2014
Cold-adapted Ann Arbor based live attenuated influenza vaccine (LAIV) has been available in the USA since 2003. The vaccine is efficacious against influenza infection. Features of LAIV include: easy administration suitable for mass immunization, cross-reactivity to drifted strains for broader coverage, and establishment of herd immunity for control of ...
Hong, Jin, Kanta, Subbarao
openaire   +2 more sources

Live Attenuated Influenza Vaccine - A review

Journal of preventive medicine and hygiene, 2011
Owing to the variability of influenza viruses, vaccine composition needs to be up-dated annually. As many variables can influence their efficacy, vaccines are still considered ?sub-optimal?. Many studies have been carried out in recent years to improve vaccines.
GASPARINI, ROBERTO   +3 more
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Live attenuated tetravalent dengue vaccine

Vaccine, 2000
The development of a live attenuated tetravalent dengue vaccine is currently the best strategy to obtain a vaccine against dengue viruses. The Mahidol University group developed candidate live attenuated vaccines by attenuation through serial passages in certified primary cell cultures.
N, Bhamarapravati, Y, Sutee
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Immunization with Live Attenuated Poliovirus Vaccine

Archives of Pediatrics & Adolescent Medicine, 1961
Live attenuated poliovirus vaccine was administered to 400 newborn infants during a three-month period (October, 1959, to January, 1960). This study was designed to obtain information which might provide answers to the following questions. Would the ingestion of larger doses permit enough of the vaccine viruses regularly to pass the "acid barrier" of ...
S, KRUGMAN   +5 more
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A Trial With Live Attenuated Rubella Vaccine

Archives of Pediatrics & Adolescent Medicine, 1968
CONTROLLED trials of a high passage rubella virus strain conducted by Meyer et al in institutionalized human subjects 1 indicated that the virus was attenuated, immunogenic, and did not spread from vaccinees to others. The present investigation was undertaken to extend these observations in younger institutionalized subjects.
M L, Lepow   +3 more
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Live Attenuated Vaccine Vectors

International Journal of Technology Assessment in Health Care, 1994
AbstractSeveral different live attenuated vaccine vectors currently are under development. These vaccines are composed of living viruses or bacteria that are innocuous to the host but can replicate in host tissues and induce immune responses. The genes encoding foreign antigens can be inserted into these vectors to produce multivalent vaccines that ...
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Live attenuated influenza vaccine

2008
The development of the live, attenuated influenza vaccine (LAIV), based on the cold-adapted (ca), attenuated ca A/Ann Arbor/6/60 and ca B/Ann Arbor/1/66 backbones, has spanned several decades. The vaccine contains three vaccine strains, two attenuated influenza A strains and one attenuated influenza B strain; these vaccine strains are genetic ...
Harry Greenberg, George Kemble
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Vaccination with Live Attenuated Measles Virus

Archives of Pediatrics & Adolescent Medicine, 1962
Introduction Isolation of the virus of measles in human tissue culture and its subsequent adaptation to growth in embryonated eggs and chick embryo cell culture by Enders and his colleagues 1-3 has led to the rapid development in the United States of vaccines suitable for use in the immunoprophylaxis of this disease.
R B, HORNICK   +2 more
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Influenza Vaccination with a Live Attenuated Vaccine

AJN, American Journal of Nursing, 2009
Influenza is a highly contagious, acute respiratory illness with a long history of outbreaks dating back several centuries. Although immunization is an effective means of protection against influenza, vaccination rates have been suboptimal, especially among certain high-risk groups, including children and health care personnel.
Michele, Michael   +4 more
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Live Attenuated Vaccines for Pandemic Influenza

2009
In this chapter, we will review the development of and clinical experience with the currently licensed seasonal live attenuated influenza vaccines (LAIV) and preclinical studies of H5, H7, and H9 live attenuated pandemic influenza vaccine candidates. Vectored vaccine approaches will not be reviewed in this chapter.
Grace L, Chen, Kanta, Subbarao
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