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Novel Approaches for The Development of Live Attenuated Influenza Vaccines [PDF]

Viruses, 2019
Influenza virus still represents a considerable threat to global public health, despite the advances in the development and wide use of influenza vaccines. Vaccination with traditional inactivate influenza vaccines (IIV) or live-attenuated influenza vaccines (LAIV) remains the main strategy in the control of annual seasonal epidemics, but it does not ...
Luis Martinez-Sobrido, Aitor Nogales, Laura Rodríguez   +2 more
exaly   +4 more sources

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Live attenuated influenza vaccine for children

Drug and Therapeutics Bulletin, 2017
For many years, the UK seasonal influenza vaccination programme has been offered to people at higher risk from the complications of influenza infection, including those aged over 65 years and anyone aged over 6 months who is in a clinical risk group.1 In 2012, the Joint Committee on Vaccination and Immunisation (JCVI) recommended extending seasonal ...
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Universal Influenza Vaccination and Live Attenuated Influenza Vaccination of Children

Pediatric Infectious Disease Journal, 2008
Influenza is an uncontrolled epidemic disease that is vaccine preventable. Each winter the peak of medically attended acute respiratory illness coincides with the peak of influenza virus activity. The anatomy of an urban influenza epidemic is presented highlighting the role of children in the spread of influenza.
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PROSPECTS OF A LIVING ATTENUATED VACCINE AGAINST INFLUENZA

Australian Journal of Experimental Biology and Medical Science, 1980
SummaryLiving attenuated vaccines offer the promise of providing more effective immunity against influenza than inactivated vaccines. However, the development of such vaccines presents unique problems, because influenza A viruses undergo frequent antigenic change and are highly infectious.
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A MURINE MODEL FOR ASSESSMENT OF LIVING ATTENUATED INFLUENZA A VACCINES

Australian Journal of Experimental Biology and Medical Science, 1980
SummaryThe laboratory mouse was evaluated as a model to assess the genetic stability of influenza A mutants of potential use as living vaccine strains. The growth of three mutant recombinants. A/Hong Kong/68‐ts‐IE (H3N2), A/HK/123/77x‐ts‐1A2 (H1N1) and A2/AA/6/60‐ca (H2N2) was studied in 15 g mice.
M C, Wark, G A, Tannock, M M, Sutherland, L E, Smith   +3 more
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Intranasal immunization with attenuated live influenza vaccine in asthma

Journal of Allergy and Clinical Immunology, 1976
Attenuated live intranasal influenza vaccine ("Alice") was given to 20 asthmatics and 9 control subjects. Pulmonary function were performed before and after, with emphasis on tests of small airways function (using flow volume curves with air and a helium-oxygen mixture).
W W, Storms, E C, Dick, W W, Busse
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Design of Alternative Live Attenuated Influenza Virus Vaccines

2014
Each year due to the ever-evolving nature of influenza, new influenza vaccines must be produced to provide protection against the influenza viruses in circulation. Currently, there are two mainstream strategies to generate seasonal influenza vaccines: inactivated and live-attenuated.
Courtney, Finch, Weizhong, Li, Daniel R, Perez   +2 more
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[Influenza live attenuated vaccine].

Nihon rinsho. Japanese journal of clinical medicine, 2001
Inactivated influenza vaccine has been widely used; however, its effectiveness is not always perfect. To create a much better vaccine, live vaccines have been extensively investigated. Among several candidate live vaccines, cold-adapted(Ca) vaccine is the only promising candidate. According to clinical studies recently conducted in the U.S., Ca vaccine
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Studies with live attenuated influenza vaccines.

American journal of clinical pathology, 1978
Inhibitor-resistant and temperature-sensitive live attenuated influenza virus vaccines were administered to normal volunteers and elderly and chronically ill persons to assess safety, antigenicity, and transmissibility. Recombinants of both types of vaccine were made using currently prevalent influenza virus strains (A/Hong Kong/68, A/England/42/72, A ...
R G, Douglas, R F, Betts
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Studies with Live Attenuated Influenza Vaccines

American Journal of Clinical Pathology, 1979
G, Florent, F, André
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