Results 1 to 10 of about 2,646 (127)

LAIV Mutations Selectively Alter Influenza Viral RNA Polymerase Function, Favoring Transcription over Genome Synthesis [PDF]

Viruses
Influenza viruses cause mild to severe lower respiratory infections, sometimes resulting in hospitalization and death. Vaccination remains the primary prophylactic strategy.
Luis Martinez-Sobrido, Stephen Dewhurst, Baek Kim   +2 more
exaly   +4 more sources

Parental preference for live-attenuated versus inactivated influenza vaccination in children: A questionnaire survey [PDF]

Human Vaccines & Immunotherapeutics
Understanding parental attitudes and factors influencing selection of influenza vaccines, including live-attenuated influenza vaccine (LAIV) and inactivated influenza vaccine (IIV), provides insights into optimizing influenza vaccine uptake.
Taito Kitano, Nami Kurosawa, Shinji Hirano, Takumi Okamura, Soshi Hachisuka, Naohiro Yamamoto, Hiroki Nishikawa, Masayuki Onaka, Rika Suzuki, Sayaka Yoshida   +9 more
doaj   +2 more sources

The Live Attenuated Influenza Vaccine in Australia: An Additional Tool for Influenza Prevention. [PDF]

Med J Aust
ABSTRACT Seasonal influenza causes significant morbidity and mortality in Australia. Despite long‐standing recommendations for influenza vaccination and nationally funded programs for higher risk age or population groups, coverage remains suboptimal, especially among children.
Patel C, Pillsbury A, Nguyen T, Wang X, Quinn HE, Chiu CK, Cheng AC, Flanagan KL, Wang Z.   +8 more
europepmc   +2 more sources

Replication in human cells supersedes serum antigenic match for the in vivo efficacy of an A/H1N1pdm09 LAIV virus [PDF]

npj Vaccines
For FluMist®/Fluenz live attenuated influenza vaccine (LAIV), efficient virus replication in human nasal epithelial cells (hNEC) is an important factor in vaccine effectiveness (VE).
Steffan Llewellyn, Katarzyna E. Schewe, Sameer Ayaz, David Burbidge, Shaun Cooper, Jonathan Crowe, Sarah Dodd, Jemma Shapanis, Katie Tudor, Kathryn Ryan, Lauren Parker, Oliver Dibben   +11 more
doaj   +2 more sources

Live Attenuated Influenza Virus as a Vector for Multivalent T-Cell Vaccines: Targeting RSV, hMPV, and PIV3 [PDF]

Vaccines
Background/Objectives: Respiratory syncytial virus (RSV), human metapneumovirus (hMPV), and parainfluenza virus type 3 (PIV3) are leading causes of acute respiratory infections in children and the elderly, yet no licensed T-cell vaccines are available ...
Tatiana Kotomina, Pei Fong Wong, Victoria Matyushenko, Nikolay Zaramenskikh, Maria Bolgar, Anna Bazhina, Ekaterina Stepanova, Larisa Rudenko, Irina Isakova-Sivak   +8 more
doaj   +2 more sources

Intranasal Mosaic H1N1 Live Attenuated Influenza Vaccine Elicits Broad Cross-Reactive Immunity and Protection Against Group 1 and 2 Influenza A Viruses. [PDF]

MedComm (2020)
Our study introduces the mosaic H1N1 LAIV, an intranasal broad‐spectrum influenza vaccine that integrates the mosaic antigen design with LAIV technology. Intranasal boosting in mice elicits robust mucosal, humoral, and cellular immunity, as well as provides extensive protection against both homologous and heterologous influenza strains.
Ma X, Chen Q, Cai Y, Chen C, Lu J, Yang Z, Han X, Wang L, Liu X, Shi Y, Zhang Y, Xin L, Chen Y, Ma R, Pang W, Bai T, Shu Y.   +16 more
europepmc   +2 more sources

Effectiveness of Influenza Vaccines and Duration of Protection Against Hospitalisation During the 2024/25 Season in Northern Ireland, UK. [PDF]

Influenza Other Respir Viruses
ABSTRACT Background Seasonal influenza causes substantial morbidity and hospitalisation each year. We estimated influenza vaccine effectiveness (VE) against laboratory‐confirmed influenza‐associated hospitalisation among patients in Northern Ireland (NI) during the 2024/25 influenza season.
Bucholc M, Murphy S, O'Doherty MG, Wilton S, Dickson E, Bradley DT.   +5 more
europepmc   +2 more sources

Effectiveness of live-attenuated and inactivated influenza vaccines against influenza in 2–17-y-old children, United States, 2022–2025 [PDF]

Human Vaccines & Immunotherapeutics
In addition to the inactivated influenza vaccine (IIV), the live attenuated influenza vaccine (LAIV) has recently been recommended in some countries.
Taito Kitano, Sayaka Yoshida
doaj   +2 more sources

Systematic review of evidence on feasibility of administering intranasal live attenuated influenza vaccine at home [PDF]

npj Vaccines
In the United States, influenza vaccination coverage in adults and children remains below target, with disparities across racial and ethnic groups and setting urbanicity. Reducing barriers to influenza vaccination may improve coverage.
Ravi Jhaveri, Neil Skolnik, Allyn Bandell   +2 more
doaj   +2 more sources

Effects of attenuated influenza virus administration to young children on pneumococcal density and acquisition in UK families: a randomised controlled trial

The Lancet Microbe
Summary: Background: The live attenuated influenza vaccine (LAIV) is offered in the UK to young children, protecting against influenza for those vaccinated, and as an indirect protection for the wider community.
Jane Metz, PhD, George Qian, PhD, Begonia Morales-Aza, BSc, Jennifer Oliver, PhD, Elizabeth Oliver, BSc, Helen Rice, MSc, Kaltun Duale, BSc, Paul Heath, Prof, Saul Faust, Prof, Matthew Snape, Prof, Stephen Hughes, MB ChB, Laura Hole, BM BS, Rebecca Mann, BMedSci, Fiona Shackley, MB ChB, Peter Rudd, MB BChir, Siân Ludman, MB BCh, Bradford Gessner, MD-MPH, Leon Danon, Prof, Adam Finn, Prof   +18 more
doaj   +2 more sources