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A Chymotrypsin-Dependent Live-Attenuated Influenza Vaccine Provides Protective Immunity against Homologous and Heterologous Viruses [PDF]

Vaccines
Influenza virus is one of the main pathogens causing respiratory diseases in humans. Vaccines are the most effective ways to prevent viral diseases. However, the limited protective efficacy of current influenza vaccines highlights the importance of novel,
Peiqing He, Mengxuan Gui, Tian Chen, Yue Zeng, Congjie Chen, Zhen Lu, Ningshao Xia, Guosong Wang, Yixin Chen   +8 more
doaj   +3 more sources

Influenza Vaccination Strategies: Comparing Inactivated and Live Attenuated Influenza Vaccines [PDF]

Vaccines, 2015
Influenza is a major respiratory pathogen causing annual outbreaks and occasional pandemics. Influenza vaccination is the major method of prophylaxis.
Saranya Sridhar, Karl A. Brokstad, Rebecca J. Cox   +2 more
doaj   +7 more sources

Safety and Viral Shedding of Live Attenuated Influenza Vaccine (LAIV) in Chinese Healthy Juveniles and Adults: A Phase Ⅰ Randomized, Double-Blind, Placebo-Controlled Study [PDF]

Vaccines, 2022
This study was a randomized, double-blind, placebo-controlled study to evaluate the safety and viral shedding of live attenuated influenza vaccine (LAIV) in Chinese healthy juveniles and adults. A total of 80 Eligible volunteers were divided into two age
Li Li, Nianmin Shi, Na Xu, Haibin Wang, Hui Zhao, Haidong Xu, Dawei Liu, Zheng Zhang, Shuping Li, Junnan Zhang, Chunhui Guo, Jinglei Huo, Menghan Zhao, Fengji Luo, Liqing Yang, Yunhua Bai, Qiang Lu, Yusong Zhang, Yi Zhong, Wenhui Gao   +19 more
doaj   +2 more sources

Intranasal Mosaic H1N1 Live Attenuated Influenza Vaccine Elicits Broad Cross‐Reactive Immunity and Protection Against Group 1 and 2 Influenza A Viruses [PDF]

MedComm
Influenza, a highly pathogenic infectious disease, causes nearly half a million deaths annually worldwide. Thus, effective vaccine‐based prevention and control are crucial.
Ximeng Ma, Qi Chen, Yukun Cai, Chen Chen, Jian Lu, Zhuolin Yang, Xue Han, Liangliang Wang, Xuejie Liu, Yuhang Shi, Yuhang Zhang, Li Xin, Yihao Chen, Run Ma, Wantong Pang, Tian Bai, Yuelong Shu   +16 more
doaj   +2 more sources

Safety, Immunogenicity and Protective Activity of a Modified Trivalent Live Attenuated Influenza Vaccine for Combined Protection Against Seasonal Influenza and COVID-19 in Golden Syrian Hamsters [PDF]

Vaccines
Background/Objectives: Influenza viruses and SARS-CoV-2 are currently cocirculating with similar seasonality, and both pathogens are characterized by a high mutational rate which results in reduced vaccine effectiveness and thus requires regular updating
Ekaterina Stepanova, Victoria Matyushenko, Daria Mezhenskaya, Ekaterina Bazhenova, Tatiana Kotomina, Alexandra Rak, Svetlana Donina, Anna Chistiakova, Arina Kostromitina, Vlada Novitskaya, Polina Prokopenko, Kristina Rodionova, Konstantin Sivak, Kirill Kryshen, Valery Makarov, Larisa Rudenko, Irina Isakova-Sivak   +16 more
doaj   +2 more sources

Safety, Immunogenicity, and Protective Efficacy of a Chimeric A/B Live Attenuated Influenza Vaccine in a Mouse Model [PDF]

Microorganisms, 2021
Influenza A and B viruses cause significant morbidity and mortality worldwide. Current influenza vaccines are composed of three or four strains: A/H1N1, A/H3N2, and B (Victoria and Yamagata lineages).
Ekaterina Stepanova, Elena Krutikova, Pei-Fong Wong, Victoria Matyushenko, Ekaterina Bazhenova, Irina Isakova-Sivak, Larisa Rudenko   +6 more
doaj   +2 more sources

Pneumococcal colonization impairs mucosal immune responses to live attenuated influenza vaccine [PDF]

JCI Insight, 2021
Influenza virus infections affect millions of people annually, and current available vaccines provide varying rates of protection. However, the way in which the nasal microbiota, particularly established pneumococcal colonization, shape the response to ...
Beatriz F. Carniel, Fernando Marcon, Jamie Rylance, Esther L. German, Seher Zaidi, Jesus Reiné, Edessa Negera, Elissavet Nikolaou, Sherin Pojar, Carla Solórzano, Andrea M. Collins, Victoria Connor, Debbie Bogaert, Stephen B. Gordon, Helder I. Nakaya, Daniela M. Ferreira, Simon P. Jochems, Elena Mitsi   +17 more
doaj   +2 more sources

H5N1 vaccine-specific B cell responses in ferrets primed with live attenuated seasonal influenza vaccines. [PDF]

PLoS ONE, 2009
Live attenuated influenza H5N1 vaccines have been produced and evaluated in mice and ferrets that were never exposed to influenza A virus infection (Suguitan et al., Plos Medicine, e360:1541, 2006).
Xing Cheng, Michael Eisenbraun, Qi Xu, Helen Zhou, Deepali Kulkarni, Kanta Subbarao, George Kemble, Hong Jin   +7 more
doaj   +1 more source

Molecular basis of live-attenuated influenza virus. [PDF]

PLoS ONE, 2013
Human influenza is a seasonal disease associated with significant morbidity and mortality. The most effective means for controlling infection and thereby reducing morbidity and mortality is vaccination with a three inactivated influenza virus strains ...
Wen He, Wei Wang, Huamin Han, Lei Wang, Ge Zhang, Bin Gao   +5 more
doaj   +1 more source

Effectiveness of the 2012/13 trivalent live and inactivated influenza vaccines in children and adolescents in Saxony-Anhalt, Germany: a test-negative case-control study. [PDF]

PLoS ONE, 2015
A live attenuated influenza vaccine has been available in Germany since the influenza season 2012/13, which is approved for children aged 2-17 years. Using data from our laboratory-based surveillance system, we described the circulation of influenza and ...
Carina Helmeke, Lutz Gräfe, Hanns-Martin Irmscher, Constanze Gottschalk, Ioannis Karagiannis, Hanna Oppermann   +5 more
doaj   +1 more source