Results 31 to 40 of about 1,768,893 (247)

MVA-based H5N1 vaccine affords cross-clade protection in mice against influenza A/H5N1 viruses at low doses and after single immunization. [PDF]

, 2009
Human infections with highly pathogenic avian influenza viruses of the H5N1 subtype, frequently reported since 2003, result in high morbidity and mortality.
Sutter, G. (Gerd), Sutter Gerd, Rimmelzwaan, Guus F., Osterhaus, A.D.M.E. (Albert), Yasemin Suezer, Gerrie de Mutsert, Suezer, Yasemin, Geert van Amerongen, Löwer, Johannes, Fouchier Ron A. M., Osterhaus, Albert D. M. E., Kreijtz, Joost H. C. M., Mutsert, Gerrie de, Fouchier, Ron A. M., Fouchier, R.A.M. (Ron), Guus F Rimmelzwaan, van den Brand Judith M. A., Löwer Johannes, Johannes Löwer, Kreijtz, J.H.C.M. (Joost), Suezer, Y., Judith M A van den Brand, Suezer Yasemin, Mutsert, G. (Gerrie) de, Amerongen, G. (Geert) van, Rimmelzwaan Guus F., Brand, J.M.A. (Judith) van den, Joost H C M Kreijtz, Sutter, Gerd, Schwantes, Astrid, de Mutsert Gerrie, Brand, Judith M. A. van den, Osterhaus Albert D. M. E., Schwantes Astrid, Scwantes, A. (Astrid), Ron A M Fouchier, van Amerongen Geert, Albert D M E Osterhaus, Gerd Sutter, Astrid Schwantes, Rimmelzwaan, G.F. (Guus), Kreijtz Joost H. C. M., Amerongen, Geert van, Löwer, J., Fouchier, Ron A.M.; id_orcid, Scwantes, Astrid, van Amerongen, Geert, van den Brand, Judith M.A., Osterhaus, Albert D.M.E., Kreijtz, Joost H.C.M., de Mutsert, Gerrie   +50 more
core   +1 more source

Hemagglutinin sequence conservation guided stem immunogen design from influenza A H3 subtype [PDF]

, 2015
Seasonal epidemics caused by influenza A (H1 and H3 subtypes) and B viruses are a major global health threat. The traditional, trivalent influenza vaccines have limited efficacy because of rapid antigenic evolution of the circulating viruses.
Citron, Michael, Ferrara, Francesca, Temperton, Nigel J., Flynn, Jessica A, Raghavan eVaradarajan, Vamsee Aditya Mallajosyula, V., Raghavan Varadarajan, Flynn, Jessica A., Temperton, Nigel J, Xiaoping eLiang, Vamsee Aditya Mallajosyula, V. Vamsee Aditya Mallajosyula, Michael Citron, Nigel J. Temperton, Xiaoping Liang, Mallajosyula, Vamsee Aditya V, Jessica A. Flynn, Liang, Xiaoping, Varadarajan, Raghavan, Michael eCitron, Francesca eFerrara, Nigel James Temperton, Jessica A Flynn, Francesca Ferrara, Mallajosyula, Vamsee V A   +24 more
core   +1 more source

The new temperature-sensitive mutation PA-F35S for developing recombinant avian live attenuated H5N1 influenza vaccine

Virology Journal, 2012
Background H5N1 highly pathogenic avian influenza virus (HPAIV) is continuously circulating in many Asian countries and threatening poultry industry and human population.
Zhang Wenting, Tu Jiagang, Zhao Zongzheng, Chen Huanchun, Jin Meilin   +4 more
doaj   +1 more source

Parenteral vaccination of mammalian livestock with Newcastle disease virus-based vector vaccines offers optimal efficacy and safety [PDF]

, 2011
Newcastle disease virus (NDV) is an avian virus that is being evaluated as a vaccine vector for the delivery of foreign genes in mammals. The use of NDV as a vaccine vector in these species offers two major advantages.
Adriaan F.G. Antonis, Kortekaas, J.A., Moormann, R.J.M., Jeroen Kortekaas, Antonis, A.F.G., Michiel M. Harmsen, Harmsen, M.M., Rob J.M. Moormann   +7 more
core   +1 more source

A Live-Attenuated Prime, Inactivated Boost Vaccination Strategy with Chimeric Hemagglutinin-Based Universal Influenza Virus Vaccines Provides Protection in Ferrets: A Confirmatory Study

Vaccines, 2018
Influenza viruses cause severe diseases and mortality in humans on an annual basis. The current influenza virus vaccines can confer protection when they are well-matched with the circulating strains.
Raffael Nachbagauer, Florian Krammer, Randy A. Albrecht   +2 more
doaj   +1 more source

MiRNA Targeted NP Genome of Live Attenuated Influenza Vaccines Provide Cross-Protection against a Lethal Influenza Virus Infection

Vaccines, 2020
The miRNA-based strategy has been used to develop live attenuated influenza vaccines. In this study, the nucleoprotein (NP) genome segment of the influenza virus was inserted by different perfect miRNA-192-5p target sites, and the virus was rescued by ...
Feixia Gao, Tianhan Yang, Xueying Liu, Feifei Xiong, Jian Luo, Yinglei Yi, Jiangfeng Fan, Ze Chen, Wen-Song Tan   +8 more
doaj   +1 more source

Live Attenuated and Inactivated Influenza Vaccine Effectiveness [PDF]

Pediatrics, 2019
BACKGROUND: Researchers in observational studies of vaccine effectiveness (VE) in which they compared quadrivalent live attenuated vaccine (LAIV4) and inactivated influenza vaccine (IIV) among children and adolescents have shown inconsistent results, and the studies have been limited by small samples.
Jessie R, Chung, Brendan, Flannery, Christopher S, Ambrose, Rodolfo E, Bégué, Herve, Caspard, Laurie, DeMarcus, Ashley L, Fowlkes, Geeta, Kersellius, Andrea, Steffens, Alicia M, Fry   +9 more
openaire   +2 more sources

Influenza H5 hemagglutinin DNA primes the antibody response elicited by the live attenuated influenza A/Vietnam/1203/2004 vaccine in ferrets. [PDF]

PLoS ONE, 2011
Priming immunization plays a key role in protecting individuals or populations to influenza viruses that are novel to humans. To identify the most promising vaccine priming strategy, we have evaluated different prime-boost regimens using inactivated, DNA
Amorsolo L Suguitan, Xing Cheng, Weijia Wang, Shixia Wang, Hong Jin, Shan Lu   +5 more
doaj   +1 more source

CpG dinucleotide enrichment in the influenza A virus genome as a live attenuated vaccine development strategy.

PLoS Pathogens, 2023
Synonymous recoding of RNA virus genomes is a promising approach for generating attenuated viruses to use as vaccines. Problematically, recoding typically hinders virus growth, but this may be rectified using CpG dinucleotide enrichment.
Colin P Sharp, Beth H Thompson, Tessa J Nash, Ola Diebold, Rute M Pinto, Luke Thorley, Yao-Tang Lin, Samantha Sives, Helen Wise, Sara Clohisey Hendry, Finn Grey, Lonneke Vervelde, Peter Simmonds, Paul Digard, Eleanor R Gaunt   +14 more
doaj   +1 more source

Adverse Events of Interest Following Influenza Vaccination in the First Season of Adjuvanted Trivalent Immunization: Retrospective Cohort Study

JMIR Public Health and Surveillance, 2022
BackgroundVaccination is the most effective form of prevention of seasonal influenza; the United Kingdom has a national influenza vaccination program to cover targeted population groups.
Simon de Lusignan, Ruby S M Tsang, Oluwafunmi Akinyemi, Jamie Lopez Bernal, Gayatri Amirthalingam, Julian Sherlock, Gillian Smith, Maria Zambon, Gary Howsam, Mark Joy   +9 more
doaj   +1 more source