Results 41 to 50 of about 3,493 (205)

Recombinant influenza A/H1N1pdm09 vaccine expressing streptococcal surface epitope for dual protection [PDF]

Exploration of Immunology
Aim: Develop A/H1N1pdm09-based live attenuated influenza vaccines (LAIVs) presenting chimeric hemagglutinin (HA) fused to fragments of Streptococcus pneumoniae (PspA, Spr1875) or S.
Yulia Desheva, Irina Mayorova, Andrey Rekstin, Polina Kudar, Andrey Trulioff, Daria Petrachkova, Tatiana Kotomina, Nina Kopylova, Anastasiia Matushkina, Daniil Sokolovsky, Danila Guzenkov, Irina Isakova-Sivak   +11 more
doaj   +1 more source

In vivo comparative analysis of live influenza vaccine candidates obtained by reverse genetics and classical reassortment

Инфекция и иммунитет
Difficulties identified in recent years while preparing reassortant live influenza vaccine (LAIV) strains related to the specific biological properties of currently circulating epidemic influenza viruses, necessitate the search for alternative ...
Natalie V. Larionova, Irina V. Kiseleva, Maya K. Vorsina, Anna K. Chistyakova, Ekaterina A. Stepanova, Larisa G. Rudenko, Ekaterina A. Bazhenova   +6 more
doaj   +1 more source

Respiratory microbiota: interactions with maternal pneumococcal immunisation and live attenuated influenza vaccine (LAIV) in children [PDF]

, 2022
Respiratory tract infections (RTIs) are a leading cause of mortality in children under five years. The high burden of RTIs is experienced in low and middle-income countries (LMICs).
Peno, Chikondi
core   +1 more source

Comparison of efficacy, safety, immune response of dNS1 LAIV and cold-adapted LAIV in a mouse model

npj Vaccines
Influenza remains a significant global public health concern. Live-attenuated influenza vaccines (LAIVs) are recognized as effective interventions for influenza prevention. Currently, two types of LAIVs are licensed for human use: one developed through cold-adapted viral gene mutation and the other through the deletion of the viral NS1 gene.
Wang, Xijing, Zhang, Xu, Chen, Congjie, Chen, Heming, Chen, Yaode, Wu, Ruotong, Chen, Xiangjie, Lu, Zhen, Xia, Ningshao, Chen, Junyu, Chen, Yixin   +10 more
openaire   +3 more sources

Factors of early protective action of live influenza vaccine combined with recombinant bacterial polypeptides against homologous and heterologous influenza infection

Heliyon, 2019
We are developing an associated vaccine based on live influenza vaccine (LAIV) and streptococcal recombinant peptides. The recombinant group B streptococcus (GBS) peptides P6 and ScaAB demonstrated a distinguished immunomodulating effect in THP-1 cells ...
Yulia A. Desheva, Galina F. Leontieva, Tatiana A. Kramskaya, Galina O. Landgraf, Ivan A. Sychev, Andrey R. Rekstin, Alexander N. Suvorov   +6 more
doaj   +1 more source

CD8+ Tissue‐Resident Memory T Cells in Health and Disease

MedComm, Volume 7, Issue 7, July 2026.
CD8+ TRM cells are at the center of immunity, mediating potent local innate and adaptive immune responses. While TRM cells mediate protective immunity against infections and tumors, they also contribute to pathological inflammation in autoimmune conditions.
Yu‐Han Ai, Ting‐Ting Xu, Sen Lin, Meng‐Yu Xiao, Yun‐Xia Lin, Hao‐Wen Ma, Yue‐Yang Liu, Yao‐Jie Wang, Lu‐Ning Yin, Mei Huang, Yong‐Da Liu, Chao Zhu, Xiao‐Ting Zhu, Ji‐Hang Yuan   +13 more
wiley   +1 more source

Safety, Immunogenicity and Protective Activity of a Modified Trivalent Live Attenuated Influenza Vaccine for Combined Protection Against Seasonal Influenza and COVID-19 in Golden Syrian Hamsters

Vaccines
Background/Objectives: Influenza viruses and SARS-CoV-2 are currently cocirculating with similar seasonality, and both pathogens are characterized by a high mutational rate which results in reduced vaccine effectiveness and thus requires regular updating
Ekaterina Stepanova, Victoria Matyushenko, Daria Mezhenskaya, Ekaterina Bazhenova, Tatiana Kotomina, Alexandra Rak, Svetlana Donina, Anna Chistiakova, Arina Kostromitina, Vlada Novitskaya, Polina Prokopenko, Kristina Rodionova, Konstantin Sivak, Kirill Kryshen, Valery Makarov, Larisa Rudenko, Irina Isakova-Sivak   +16 more
doaj   +1 more source

Live Attenuated Influenza Vaccine in Pediatric Liver Transplant Recipients: A Retrospective Series

Pediatric Transplantation, Volume 30, Issue 7, July 2026.
ABSTRACT Background Influenza remains a significant cause of morbidity and mortality in pediatric patients, particularly among solid organ transplant (SOT) recipients. Live attenuated influenza vaccines (LAIV) historically have been contraindicated in SOT recipients, with very limited data on the safety of administration after SOT. Methods We report on
Emily Merritt, Caitlin Brammer, William Otto, Anna Borgemenke, Grant Paulsen, Hannah Bahakel, Hilary Miller‐Handley, Kathleen Campbell, Lara Danziger‐Isakov   +8 more
wiley   +1 more source

Diagram of LAIV production by classical reassortment and cloning.

, 2014
Diagram of LAIV production by classical reassortment and cloning.
Julie M. Villanueva (463962), Nicholas C. Pearce (539308), Marnie L. Levine (539309), Alexander I. Klimov (240036), Svetlana V. Shcherbik (539307), Tatiana L. Bousse (539310)   +5 more
core   +1 more source

Protection of children against influenza: Emerging problems

Human Vaccines & Immunotherapeutics, 2018
Influenza is a common disease and in children it can be severe enough to lead to hospitalization and death. Protection of all children against influenza, particularly the youngest, is strongly recommended by most health authorities.
Nicola Principi, Susanna Esposito
doaj   +1 more source