Results 91 to 100 of about 1,530,452 (285)

Reassortment incompetent live attenuated and replicon influenza vaccines provide improved protection against influenza in piglets. [PDF]

Swine influenza A viruses (swIAV) cause an economically important respiratory disease in modern pig production. Continuous virus transmission and antigenic drift are difficult to control in enzootically infected pig herds. Here, antibody-positive piglets
Lillie-Jaschniski, Kathrin, Schmies, Kathrin, Summerfield, Artur, Ciminski, Kevin, Harder, Timm, Zimmer, Gert, Helmer, Carina, Harder, Timm C., Graaf-Rau, Annika, Sehl-Ewert, Julia, Beer, Martin, Breithaupt, Angele, Grosse Beilage, Elisabeth, Schwemmle, Martin, Bielenberg, Wiebke   +14 more
core   +2 more sources

OTUD6A‐Mediated Deubiquitination of PRDX1 Protects Against Oral Ulcer by Restoring Mitochondrial Function

Advanced Science, EarlyView.
In human oral keratinocytes, OTUD6A promoted cell migration by deubiquitinating and stabilizing PRDX1. Conversely, OTUD6A deficiency reduced PRDX1 stability, triggering mitochondrial dysfunction and aggravating OU progression. ABSTRACT Oral ulcers (OU), as the most highly prevalent and recurrent oral mucosal lesion, have an unclear pathogenesis that ...
Xiaoyu Sun, Ruiwei Jia, Xingbei Pan, Rui Huang, Jiahong Chen, Ziyi Yao, Lei Yin, Jun Ma, Hongjieliang Wang, Xinyu Huang, Yilin Ma, Yifan Ping, Yuanyuan Chen, Huining Wang, Shengbin Huang, Guang Liang   +15 more
wiley   +1 more source

Effect of Mycobacterium vaccae (SRL172) immunotherapy on radiographic healing in tuberculosis. [PDF]

, 2004
OBJECTIVE: Controlled trials have failed to show an effect of Mycobacterium vaccae immunotherapy on treatment outcome and mortality in patients with tuberculosis (TB); however, several studies have suggested improvement in radiographic clearing and ...
Mugerwa, RD, Onyebujoh, P, Ormerod, LP, Johnson, JL, Zumla, A, Nunn, AJ, Mwinga, A, Fourie, PB, Chintu, C, Ngwira, B   +9 more
core   +2 more sources

Single cell transcriptomics correlate avian coronavirus prime vaccination efficacy with antigen-presenting cell preference

npj Vaccines
Biosafe and effective vaccines are urgently needed for the prevention and control of avian infectious bronchitis virus (IBV), the first coronavirus to be discovered, despite extensive vaccination for decades.
Xuefeng Li, Yumeng Liang, Yu Zhang, Botao Fa, Zheyi Liu, Lu Cui, Miaomiao Xi, Shufeng Feng, Li Xu, Xiaoxiao Liu, Zhengtao Xiao, Shengwang Liu, Hai Li   +12 more
doaj   +1 more source

PROTAC‐Engineered Protein/DNA Nanoantigen is a Potent Booster for Dendritic Cell Vaccines in Cancer Immunotherapy

Advanced Science, EarlyView.
A PROTAC‐functionalized protein/DNA‐integrated nanoantigen platform is developed to enhance dendritic cell vaccine potency. By combining a VHL‐recruiting peptide‐modified antigen with a sustained expression plasmid within CaCO3 nanoparticles, this system amplifies cross‐presentation, promotes DC maturation, and elicits robust Th1 and CTL responses ...
Peng Liu, Qiang Chen, Zhe Zhou, Yuekang Xu, Jinyao Li   +4 more
wiley   +1 more source

Live attenuated oral cholera vaccines

Expert Review of Vaccines, 2006
Live, orally administered, attenuated vaccine strains of Vibrio cholerae have many theoretical advantages over killed vaccines. A single oral inoculation could result in intestinal colonization and rapid immune responses, obviating the need for repetitive dosing. Live V.
Edward T, Ryan, Stephen B, Calderwood, Firdausi, Qadri   +2 more
openaire   +2 more sources

An investigation of novel DNA based vaccines for protection against Brucellosis [PDF]

This thesis describes design, construction and evaluation in a BALB/c mouse model, for five novel Brucella specific DNA vaccines. Brucellosis is worldwide zoonosis of economic significance that poses a significant threat to both animal and human health ...
Commander, Nicola Jane
core   +1 more source

High-throughput screening with the Eimeria tenella CDC2-related kinase2/cyclin complex EtCRK2/EtCYC3a [PDF]

, 2012
The poultry disease coccidiosis, caused by infection with Eimeria spp. apicomplexan parasites, is responsible for enormous economic losses to the global poultry industry.
Engels, Kristin K., Marhofer, Richard J., Bender, Frank, Mottram, Jeremy C., Gassel, Michael, Selzer, Paul M., Fernandez, Maria L. Suarez   +6 more
core   +1 more source

Disease‐Stage Synchronized Nanozyme Therapy for Polymicrobial Sepsis through Adaptive Catalytic and Immune Reprogramming

Advanced Science, EarlyView.
A disease‐stage synchronized nanozyme platform is developed to treat polymicrobial sepsis by adapting its functions to changing infection environments. The system eliminates multidrug‐resistant bacteria during early infection while reducing inflammation and restoring immune balance during recovery, providing an integrated strategy for infection control
Anlai Zou, Xiaoxue Zhu, Runhan Zhu, Chengchu Xue, Qinyu Zhang, Mengke Li, Ting Yu, Yuzhen Gao, Zhi Ruan, Ying Fu, Yunlei Xianyu, Jun Zhang   +11 more
wiley   +1 more source

Comparative Study of the Temperature Sensitive, Cold Adapted and Attenuated Mutations Present in the Master Donor Viruses of the Two Commercial Human Live Attenuated Influenza Vaccines

, 2019
Influenza viruses cause annual, seasonal infection across the globe. Vaccination represents the most effective strategy to prevent such infections and/or to reduce viral disease.
Baek Kim, Andrew Smith, Tatsuya Maehigashi, Stephen Dewhurst, Emma C. Reilly, David J. Topham, Aitor Nogales, Pilar Blanco-Lobo, Laura Rodriguez, Luis Martínez-Sobrido   +9 more
core   +1 more source