Development of dengue vaccines [PDF]
, 2018 Background: Dengue virus (DENV) causes up to 390 million infections yearly, of which 96 million are clinically manifested. Approximately 500,000 people with severe dengue require hospitalization each year and there are at least 25,000 deaths among ...
Lim, Chee Siean *, Poh, Chit Laa *
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Synthetic biology-inspired development of live attenuated influenza vaccines
npj VaccinesLive attenuated influenza vaccines (LAIVs) provide robust, cross-protective immunity but have traditionally been developed empirically and are associated with safety concerns.
Qisi Zhang +14 more
doaj +1 more source
PLoS ONE, 2020 Vaccination against lumpy skin disease (LSD) is crucial for maintaining the health of animals and the economic sustainability of farming. Either homologous vaccines consisting of live attenuated LSD virus (LSDV) or heterologous vaccines consisting of ...
Alexander Sprygin +9 more
doaj +1 more source
Journal of Infection in Developing Countries, 2020 Coronavirus disease 2019 (COVID-19) represents a severe global public health threat. Caused by SARS-Cov-2, COVID-19 is characterized by high transmission rate that correlates with high viral load.
Jomana W Alsulaiman +2 more
doaj +1 more source
A bivalent live-attenuated influenza vaccine for the control and prevention of H3N8 and H3N2 canine influenza viruses [PDF]
, 2017 Canine influenza viruses (CIVs) cause a contagious respiratory disease in dogs. CIV subtypes include H3N8, which originated from the transfer of H3N8 equine influenza virus (EIV) to dogs; and the H3N2, which is an avian-origin virus adapted to infect ...
Martínez-Sobrido, Luis +4 more
core +1 more source
Live-attenuatedShigellavaccines
Expert Review of Vaccines, 2006 Several live-attenuated Shigella vaccines, with well-defined mutations in specific genes, have shown great promise in eliciting significant immune responses when given orally to volunteers. These responses have been measured by evaluating antibody-secreting cells, serum antibody levels and fecal immunoglobulin A to bacterial lipopolysaccharide and to ...
Malabi M, Venkatesan, Ryan T, Ranallo
openaire +2 more sources
VaccinesInfluenza virus is one of the main pathogens causing respiratory diseases in humans. Vaccines are the most effective ways to prevent viral diseases. However, the limited protective efficacy of current influenza vaccines highlights the importance of novel,
Peiqing He +8 more
doaj +1 more source
The Analysis of Live-Attenuated Piscirickettsia salmonis Vaccine Reveals the Short-Term Upregulation of Innate and Adaptive Immune Genes in Atlantic Salmon (Salmo salar): An In Situ Open-Sea Cages Study [PDF]
, 2021 Deborah Vargas +7 more
openalex +1 more source
Tuberculosis and gender: exploring the patterns in a case control study in Malawi. [PDF]
, 2004 BACKGROUND: In many populations there is an excess of tuberculosis in young women and older men. We explored possible explanations for these patterns, concentrating on human immunodeficiency virus (HIV) status, pregnancy, smoking, cooking smoke exposure,
Crampin, AC +8 more
core
Variable protection against experimental broiler necrotic enteritis after immunisation with the C-terminal fragment of Clostridium perfringens alpha-toxin and a non-toxic NetB variant [PDF]
, 2016 Necrotic enteritis toxin B (NetB) is a pore-forming toxin produced by Clostridium perfringens and has been shown to play a key role in avian necrotic enteritis (NE), a disease causing significant costs to the poultry production industry worldwide.
Bokori-Brown, Monika +5 more
core +3 more sources