Results 71 to 80 of about 1,140,955 (307)

Probability of second live birth after first natural and medically assisted reproduction‐mediated live birth: A historical cohort study

Acta Obstetricia et Gynecologica Scandinavica
Introduction Evidence on the role of medically assisted reproduction (MAR) in achieving the desired number of children is very limited. The aim of the current investigation was to assess the probability and the mode of conception of a second live birth ...
Giovanna Esposito, Fabio Parazzini, Paola Viganò, Matteo Franchi, Sonia Cipriani, Francesco Fedele, Giovanni Corrao, Edgardo Somigliana   +7 more
doaj   +1 more source

Viviparity stimulates diversification in an order of fish

Nature Communications, 2016
Live birth and an annual life cycle potentially enable access to new ecological niches and subsequent species diversification. Here, Helmstetter et al.build the phylogeny for fish in the order Cyprinodontiformes and find that, though live birth and ...
Andrew J. Helmstetter, Alexander S. T. Papadopulos, Javier Igea, Tom J. M. Van Dooren, Armand M. Leroi, Vincent Savolainen   +5 more
doaj   +1 more source

Comparing the cumulative live birth rate of cleavage-stage versus blastocyst-stage embryo transfers between IVF cycles: a study protocol for a multicentre randomised controlled superiority trial (the ToF trial) [PDF]

, 2021
Simone Cornelisse, Liliana Ramos, Brigitte Arends, Janneke J. Brink-van der Vlugt, Jan Peter de Bruin, Max HJN Curfs, Josien G. Derhaag, Angelique van Dongen, Jannie van Echten‐Arends, E.R. Groenewoud, Jacques W.M. Maas, Q. D. Pieterse, Evert JP van Santbrink, Els Slappendel, M A F Traas, Jantien Visser, C.G. Vergouw, Harold R Verhoeve, Lucette AJ van der Westerlaken, Yvonne Wurth, Moniek van der Zanden, D.D.M. Braat, Madelon van Wely, Sebastiaan Mastenbroek, Kathrin Fleischer   +24 more
openalex   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

Molecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece, Giulio Lovato, Ilaria Cela, Arianna Mercatelli, Benedetta Ferro, Jussi Nikkola, Sara Pagotto, Tommaso Grottola, Vincenzo De Laurenzi, Rossella Cicchetti, Antonio Marchetti, Luigi Schips, Rossano Lattanzio, Stefano Iacobelli, Emily Capone, Peter Black, Mads Daugaard, Michele Marchioni, Gianluca Sala   +18 more
wiley   +1 more source

Early prediction of live birth for assisted reproductive technology patients: a convenient and practical prediction model

Scientific Reports, 2021
Live birth is the most important concern for assisted reproductive technology (ART) patients. Therefore, in the medical reproductive centre, obstetricians often need to answer the following question: “What are the chances that I will have a healthy baby ...
Hong Gao, Dong-e Liu, Yumei Li, Xinrui Wu, Hongzhuan Tan   +4 more
doaj   +1 more source

Safety of efavirenz in the first trimester of pregnancy: an updated systematic review and meta-analysis [PDF]

, 2011
Article approval pendingEvidence of the risk of birth defects with efavirenz use is limited. We updated a meta-analysis of birth defects in infants with first trimester efavirenz exposure up to July 2011.
Alexandra Calmy, Areechokchai, Bera, Blood, Bussmann, Ekouevi, Floridia, Ford, Jeantils, Lynne Mofenson, Machado, Nathan Ford, Patel, Rossouw, Townsend   +14 more
core   +2 more sources

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source

Live bearing promotes the evolution of sociality in reptiles

Nature Communications, 2017
Live birth may be a precursor for parent-offspring associations and subsequent sociality, but the ubiquity of live birth in mammals and parental care in birds precludes testing the relationship in those clades.
Ben Halliwell, Tobias Uller, Barbara R. Holland, Geoffrey M. While   +3 more
doaj   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source