Results 61 to 70 of about 1,882,484 (309)

Who gets to decide? Matters arising from Robinson et al. (2024), “Can people with longstanding bulimia nervosa suffer from severe and enduring eating disorder? A qualitative study”

Journal of Eating Disorders
Written by a researcher with lived experience of long-standing bulimia nervosa, this Matters Arising piece commends Robinson et al. (2024)’s study for its focus on exploring the subjective experiences of patients who are often overlooked in clinical and ...
James Downs
doaj   +1 more source

Mesolithic Europe : glimpses of another world [PDF]

, 2008
[First Paragraph] Mesolithic Europe holds a special place in our imagination. Perhaps more than any other region and period, it is unique in conjuring up a strange sense of both 'otherness' and familiarity.
Spikins, Penny
core  

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Development of the Japanese Version of the Views on Inpatient Care (VOICE-J): Service Users’ Perspectives on Psychiatric Inpatient Care

Journal of Patient Experience
The quality of psychiatric inpatient care is a pressing concern in Japan, where hospitalization is prolonged and coercive practices remain common. Incorporating patients’ perspectives is essential for evaluation and service improvement.
Yuki Miyamoto RN, PHN, PhD, Risa Kotake RN, MSc, Emiko Otsu-Mitsui MSN, RN, PHN, CNS, Manami Tsunemoto, Tomoko Shinmura, Utako Sawada RN, PhD, Kaori Tsuzuki, Neteru Masukawa, Jo Evans MA, MSc, Daisuke Nishi MD, PhD   +9 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source

Facilitators and barriers to participation of patients with treatment resistant depression in a randomised controlled trial of two forms of personalised magnetic resonance imaging targeted transcranial magnetic stimulation (the BRIGhTMIND trial)

BMC Psychiatry
Background Magnetic resonance imaging (MRI) can personalise the site of transcranial magnetic stimulation (TMS) delivered as a course of 20 sessions for treatment-resistant depression (TRD). Facilitators and barriers to a randomised controlled trial (RCT)
Clement Boutry, Lucy Webster, Louise Thomson, Delilah Harding, Isabel Reid, Peter Bates, John Gledhill, Rebecca McNaughton, Jane Eastham, Joanne Ooi, Andy Willis, Sonal Marner, Richard Morriss   +12 more
doaj   +1 more source

The Lived Experience of Bipolar Disorder: A Systematic Review and Meta-Synthesis [PDF]

, 2016
The purpose of this meta-synthesis was to review the available qualitative research on the lived experience of persons with bipolar disorder in order to find common themes that may enhance practitioner understanding.
Cooke, Nathan, Corcoran, Jacqueline, Crooks, Paula, Cummings, Cory, Walsh, Joseph   +4 more
core   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Exploring disparities: a regional analysis of harm reduction supply distribution and opioid-related deaths across Ontario’s Public Health Units

Harm Reduction Journal
Background It is critical that a range of harm reduction supplies are available through Ontario’s Public Health Units (PHU) to meet the varying needs of people who use drugs.
Shaleesa Ledlie, Kristy Scarfone, Dana Shearer, Nadia Zurba, Miroslav Miskovic, Charlotte Munro, Jes Besharah, Shauna Pinkerton, Tyler Watts, Tara Gomes   +9 more
doaj   +1 more source