Results 61 to 70 of about 4,859,999 (297)

How Lived Experience Advisory Groups Contribute to the Design and Conduct of Mental Health Research

Health Expectations
Introduction The positive impact of patient and public involvement (PPI) on the relevance, accessibility and acceptability of mental health research is well documented.
Jo Evans, Samuel Keightley, Angela Sweeney, Rosie Hill, Ezekiel Khayri, Sarah Markham, Til Wykes   +6 more
doaj   +1 more source

Research Imitates Life: Researching Within Your Lived Experience [PDF]

This personal narrative article seeks to bring awareness to and provide an overview of the various aspects that come with being a lived experience researcher including the host of benefits and challenges that come with conducting research within one\u27s
Bethany Donaghy, Donaghy, Bethany, Linkiewich, Delane, Delane Linkiewich   +3 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

A three-way partnership: reflections and lessons from co-producing social care research with practitioners, researchers and the public

Research Involvement and Engagement
Background Co-production in social care research seeks to bridge the gap between academic inquiry, frontline practice, and lived experience by actively involving practitioners, researchers, and public members as equal partners throughout the research ...
Julia Greig, Wenjing Zhang, Kate Wortham, Karin Webb, Eirini-Christina Saloniki, Robin Darton, Ann-Marie Towers, Helen Salisbury, Janet Richardson-Simmonds, Sharon Leaver   +9 more
doaj   +1 more source

The Lived Experience [PDF]

New Theatre Quarterly, 2002
JAN KOTT was a seminal critical mind of the twentieth century and one of the last of its theatre intellectuals. I mourn him as a friend and colleague. It is now almost half a century since this Polish expatriate first published Shakespeare Our Contemporary, a book that exploded our thinking about how Shakespeare could be produced on stage.
openaire   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Who gets to decide? Matters arising from Robinson et al. (2024), “Can people with longstanding bulimia nervosa suffer from severe and enduring eating disorder? A qualitative study”

Journal of Eating Disorders
Written by a researcher with lived experience of long-standing bulimia nervosa, this Matters Arising piece commends Robinson et al. (2024)’s study for its focus on exploring the subjective experiences of patients who are often overlooked in clinical and ...
James Downs
doaj   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source