Results 71 to 80 of about 293,560 (258)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Pandemic impact, mitigation strategies and peer support: a qualitative analysis of youth, parent, clinician and administrator perspectives

Journal of Eating Disorders
Objectives This study describes views on the impact of the COVID-19 pandemic on eating disorder symptoms in youth, as well as the impact on care, and the possibility of peer support as a mitigating strategy from the perspectives of youth and parents with
Jennifer Couturier, Maria Nicula, Cheryl Webb, Gina Dimitropoulos, Nicole Obeid, Melissa Kimber, Techiya Loewen, Anne Marie Coolen, Erica Crews, Shaleen Jones, Cendrine Tremblay, Wendy Preskow, Gail McVey, Lori Wozney   +13 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Barriers to accessing prescribed medical cannabis: qualitative insights from people using non-prescribed cannabis for medicinal purposes in the Netherlands

Harm Reduction Journal
Background Although medical cannabis has been legally available by prescription in the Netherlands for more than two decades, few individuals use it. Instead, most people who use cannabis for therapeutic purposes continue to obtain it through unregulated,
Lisa Strada, Nadine van Gelder, Thomas Martinelli, Alex Fraser, Bethany Hipple Walters   +4 more
doaj   +1 more source

Setting research priorities for palliative and end-of-life care: a James Lind Alliance Priority Setting Partnership Refresh

BMJ Open
Background Palliative care supports the physical, emotional, social and spiritual needs of people with serious life-limiting illness. Future research must align with the priorities of people approaching the end of their lives, and those close to them ...
Sarah Holmes, Ollie Minton, Ben Bowers, Briony F Hudson, Mary Rabbitte, Alison Penny, Melanie Taylor, Rashmi Kumar, Diana Robinson, Angela McCullagh, Jennifer Bedford, Jamilla Hussain, Annabel Dawson, Jessica Bush, Charlotte Simpson-Greene, Phillippa Ashcroft, Louisa Nicoll, Alexandra Reece, Sabine L Best   +18 more
doaj   +1 more source

Interferon beta drives therapy resistance in a patient‐derived model of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant, Tise Suzuki, Kiera McGivney, V. S. S. Abhinav Ayyadevara, Sharon Asariah, Jay Deng, Ethan Nyein, Jacqueline Coats, Gary Yu, Yevgeniya J. Ioffe, Christian Hurtz, Juli J. Unternaehrer   +11 more
wiley   +1 more source

Medical management and differential diagnosis of restrictive eating disorders in men: a case study report with co-produced recommendations

Journal of Eating Disorders
Background Males with eating disorders (EDs) are an underrepresented population whose symptomatology and treatment needs are poorly understood, having been overlooked in clinical research to date.
James Downs, Clive Kelly
doaj   +1 more source

Peer Work and Stigma Reduction in Australian Mental Health Policy: Tackling Sanism or Reinforcing the Status Quo?

Studies in Social Justice
Peer workers are increasingly included as part of mental health policy approaches to stigma, reflecting ongoing imperatives to include lived experience within mental health policy and practice.
Aimee Sinclair, Christina Fernandes, Sue Gillieatt, Lyn Mahboub, Simon Katterl   +4 more
doaj   +1 more source