Results 51 to 60 of about 4,859,999 (297)

Lived experience: A constant companion for the social work relationship (Editorial)

, 2022
Centring and valuing lived experience flips the dynamic where traditionally knowledge and expertise on a problem often comes from professions, institutions, authorities, and governments that have studied or assessed a situation detached from direct ...
O’Leary, P, Tsui, MS
core   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Understanding the lived experience of maladaptive daydreaming [PDF]

, 2021
Section A: Maladaptive Daydreaming (MD) is a distressful phenomenon with limited understanding and recognition, which leads to controversy regarding potential diagnostic classification.
Lucas, A.
core  

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Commercial or industrial use of mental health data for research: primer and best-practice guidelines from the DATAMIND patient/public Lived Experience Advisory Group

Frontiers in Psychiatry
BackgroundRoutinely collected health data, such as that held by United Kingdom (UK) national health services (NHS), has important research uses. However, its use requires public trust and transparency.
Linda A. Jones, Corrine Barber, Naomi Clements-Brod, Jan Davies, Marcos DelPozo-Banos, Andrea Hughes, Matthew H. Iveson, Diksha Jain, Ann John, Aideen Maguire, Clara Martins de Barros, Andrew M. McIntosh, Michael McTernan, Jan Speechley, Robert J. Stewart, Robert J. Stewart, Jane Taylor, Jane Taylor, Louise Ting, Rudolf N. Cardinal, Rudolf N. Cardinal, Rudolf N. Cardinal   +21 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Co-designing health profession education with lived experience expertise: Recommendations for university practice

, 2023
This resource provides guidance and suggestions on how to co-design health professional education. The intended audience is people with lived experience and health educators who are partnering to design and deliver health profession curriculum, or who ...
Roberts, M, Stewart, V, Walder, K, Slattery, M, Gawne, H, Bissett, M   +5 more
core   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

“It’s like going through life at a mediocre level”: a qualitative study of the meaning and impact of fatigue in children and young people with sickle cell disease

BMC Pediatrics
Background Fatigue is increasingly recognised as a prevalent and debilitating symptom for children and young people (CYP) with long-term conditions (LTCs), significantly affecting their family, social and educational participation. In sickle cell disease
Brenda Agyeiwaa Poku, Karl Michael Atkin, John David Grainger, Iyamide Thomas, Rachael Oshinbolu, Abubakar Mohammed, Edith Kyewalyanga, Susan Kirk   +7 more
doaj   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source