Results 51 to 60 of about 4,828,104 (248)

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Call for Submissions Special Issue - July 2020: Patient & Family Experience in Behavioral Health [PDF]

, 2019
Patient Experience Journal (PXJ) is excited to announce the call for submissions for its July 2020 special issue on the topic of patient & family experience in behavioral health. With a continued focus on the critical role of behavioral health in society
Journal, Patient Experience, Patient Experience Journal   +1 more
core   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Commercial or industrial use of mental health data for research: primer and best-practice guidelines from the DATAMIND patient/public Lived Experience Advisory Group

Frontiers in Psychiatry
BackgroundRoutinely collected health data, such as that held by United Kingdom (UK) national health services (NHS), has important research uses. However, its use requires public trust and transparency.
Linda A. Jones, Corrine Barber, Naomi Clements-Brod, Jan Davies, Marcos DelPozo-Banos, Andrea Hughes, Matthew H. Iveson, Diksha Jain, Ann John, Aideen Maguire, Clara Martins de Barros, Andrew M. McIntosh, Michael McTernan, Jan Speechley, Robert J. Stewart, Robert J. Stewart, Jane Taylor, Jane Taylor, Louise Ting, Rudolf N. Cardinal, Rudolf N. Cardinal, Rudolf N. Cardinal   +21 more
doaj   +1 more source

Research Imitates Life: Researching Within Your Lived Experience [PDF]

This personal narrative article seeks to bring awareness to and provide an overview of the various aspects that come with being a lived experience researcher including the host of benefits and challenges that come with conducting research within one\u27s
Bethany Donaghy, Donaghy, Bethany, Linkiewich, Delane, Delane Linkiewich, Donaghy, B, Linkiewich, D   +5 more
core   +1 more source

Undergraduate student wellbeing: The lived experience in higher education [PDF]

, 2022
The wellbeing of undergraduate students in Higher Education (HE) is often associated with the student experience. Previous research has shown that measuring wellbeing is problematic because of its complexity.
Wornast, T., Van Vuuren-Cassar, G.
core  

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Exploring what the notion of lived experience might offer for social policy analysis [PDF]

, 2019
In this article, we suggest that social policy may be on the cusp of a large-scale adoption of the notion of lived experience. However, within social policy and allied disciplines, the growing use of the term ‘lived experience’ is unaccompanied by ...
McIntosh, Ian, SHARON WRIGHT, Wright, Sharon, IAN MCINTOSH   +3 more
core   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

“It’s like going through life at a mediocre level”: a qualitative study of the meaning and impact of fatigue in children and young people with sickle cell disease

BMC Pediatrics
Background Fatigue is increasingly recognised as a prevalent and debilitating symptom for children and young people (CYP) with long-term conditions (LTCs), significantly affecting their family, social and educational participation. In sickle cell disease
Brenda Agyeiwaa Poku, Karl Michael Atkin, John David Grainger, Iyamide Thomas, Rachael Oshinbolu, Abubakar Mohammed, Edith Kyewalyanga, Susan Kirk   +7 more
doaj   +1 more source