Results 101 to 110 of about 6,082,873 (391)

Impact of cirrhosis on long‐term survival outcomes of patients with intrahepatic cholangiocarcinoma

Cancer Medicine, 2022
Background The correlation between cirrhosis and the long‐term oncological outcome in intrahepatic cholangiocarcinoma (ICC) is debatable, and this study aimed to explore the impact of cirrhosis on the long‐term prognosis of patients with ICC.
Jian Wang, Yiwen Qiu, Yi Yang, Shu Shen, Ming Zhi, Bo Zhang, Wentao Wang   +6 more
doaj   +1 more source

Resolving the fibrotic niche of human liver cirrhosis at single cell level

Nature, 2019
Liver cirrhosis is a major cause of death worldwide and is characterized by extensive fibrosis. There are currently no effective antifibrotic therapies available.
P. Ramachandran, R. Dobie, J. Wilson-Kanamori, Elena Dorà, Beth E. P. Henderson, N. Luu, N. Luu, J. R. Portman, Kylie P. Matchett, M. Brice, John A. Marwick, R. S. Taylor, M. Efremova, R. Vento-Tormo, N. Carragher, T. Kendall, J. Fallowfield, E. Harrison, D. Mole, D. Mole, S. Wigmore, S. Wigmore, Phil N. Newsome, Phil N. Newsome, C. Weston, C. Weston, J. Iredale, Frank Tacke, J. Pollard, J. Pollard, C. Ponting, J. Marioni, J. Marioni, S. Teichmann, Sarah A. Teichmann, N. Henderson   +35 more
semanticscholar   +1 more source

Diagnosis and Treatment of Alcohol‐Associated Liver Diseases: 2019 Practice Guidance From the American Association for the Study of Liver Diseases

Hepatology, 2020
Alcoholic liver disease (ALD) represents a spectrum of liver injury resulting from alcohol use, ranging from hepatic steatosis to more advanced forms including alcoholic hepatitis (AH), alcoholic cirrhosis (AC), and acute alcoholic hepatitis presenting ...
D. Crabb, G. Im, G. Szabo, Jessica L. Mellinger, M. Lucey   +4 more
semanticscholar   +1 more source

Circulating histones as clinical biomarkers in critically ill conditions

FEBS Letters, EarlyView.
Circulating histones are emerging as promising biomarkers in critical illness due to their diagnostic, prognostic, and therapeutic potential. Detection methods such as ELISA and mass spectrometry provide reliable approaches for quantifying histone levels in plasma samples.
José Luis García‐Gimenez, Juan Carlos Ruiz‐Rodríguez, Ricard Ferrer, Raquel Durá, Antonio Artigas, Iván Bajaña, David Bolado López de Andujar, Irene Cánovas‐Cervera, Adrián Ceccato, Luis Chiscano‐Camón, Elena Climent‐Martinez, Georgia García Fernández, Gemma Goma, Verónica Monforte, Beatriz Quevedo‐Sánchez, Adolf Ruiz‐Sanmartín, Antonio Sierra‐Rivera, Nieves Carbonell Monleón   +17 more
wiley   +1 more source

Time and dose-dependent effects of phenobarbital on the rat liver miRNAome. [PDF]

, 2013
In a previous study we had shown that treatment of male Fischer rats with exogenous chemicals for three months resulted in prominent, mode-of-action dependent effects on liver microRNA (miRNA) (Koufaris et al., 2012). Here we investigated how the effects
Currie, RA, Gooderham, NJ, Koufaris, C, Osborne, M, Wright, J   +4 more
core   +1 more source

The prognostic value of microvascular invasion in early-intermediate stage hepatocelluar carcinoma: a propensity score matching analysis

BMC Cancer, 2018
Background Microvascular invasion (MVI) is well established as a negative prognostic factor for hepatocelluar carcinoma (HCC). However, its prognostic value in different subgroups of Barcelona Clinical Liver Cancer (BCLC) stages remains to be elucidated.
Junyi Shen, Jun Wen, Chuan Li, Tianfu Wen, Lvnan Yan, Bo Li, Jiayin Yang, Changli Lu   +7 more
doaj   +1 more source

An mALBI-Child–Pugh-based nomogram for predicting post-hepatectomy liver failure grade B–C in patients with huge hepatocellular carcinoma: a multi-institutional study

World Journal of Surgical Oncology, 2022
Objective Post-hepatectomy liver failure (PHLF) is a severe complication in patients with hepatocellular carcinoma (HCC) who underwent hepatectomy.
Ming-Hao Xu, Bin Xu, Chen-Hao Zhou, Zhong Xue, Zhao-Shuo Chen, Wen-Xin Xu, Cheng Huang, Xiao-Dong Zhu, Jian Zhou, Jia Fan, Hui-Chuan Sun, Ying-Hao Shen   +11 more
doaj   +1 more source

Noninvasive Assessment of Liver Disease in Patients With Nonalcoholic Fatty Liver Disease.

Gastroenterology, 2019
Nonalcoholic fatty liver disease (NAFLD) is estimated to afflict approximately 1 billion individuals worldwide. In a subset of NAFLD patients, who have the progressive form of NAFLD termed nonalcoholic steatohepatitis (NASH), it can progress to advanced ...
L. Castéra, M. Friedrich-Rust, R. Loomba   +2 more
semanticscholar   +1 more source

Liver injury during highly pathogenic human coronavirus infections

Liver international (Print), 2020
The severe acute respiratory syndrome coronavirus 2 (SARS‐Cov‐2), the pathogen of 2019 novel coronavirus disease (COVID‐19), has posed a serious threat to global public health.
Ling Xu, Jia Liu, Mengji Lu, Dongliang Yang, Xin Zheng   +4 more
semanticscholar   +1 more source

Single‐cell insights into the role of T cells in B‐cell malignancies

FEBS Letters, EarlyView.
Single‐cell technologies have transformed our understanding of T cell–tumor cell interactions in B‐cell malignancies, revealing new T‐cell subsets, functional states, and immune evasion mechanisms. This Review synthesizes these findings, highlighting the roles of T cells in pathogenesis, progression, and therapy response, and underscoring their ...
Laura Llaó‐Cid
wiley   +1 more source