Results 171 to 180 of about 4,693,650 (362)

Cytoplasmic Endonuclease G promotes nonalcoholic fatty liver disease via mTORC2-AKT-ACLY and endoplasmic reticulum stress [PDF]

, 2023
Wenjun Wang, Junyang Tan, Xiaomin Liu, Wenqi Guo, Mengmeng Li, Xinjie Liu, Yanyan Liu, Wenyu Dai, Liubing Hu, Yimin Wang, Qiuxia Lu, Wen Xing Lee, Hong-Wen Tang, Qinghua Zhou   +13 more
openalex   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Development and Validation of a Deep Learning System for Staging Liver Fibrosis by Using Contrast Agent–enhanced CT Images in the Liver

, 2018
Kyu Jin Choi, Jong Keon Jang, Seung Soo Lee, Yu Sub Sung, Woo Hyun Shim, Ho Sung Kim, Jessica Yun, Jin‐Young Choi, Yedaun Lee, Bo-Kyeong Kang, Jin Hee Kim, So Yeon Kim, Eun Sil Yu   +12 more
openalex   +2 more sources

Mettl14-Mediated m6A Modification Facilitates Liver Regeneration by Maintaining Endoplasmic Reticulum Homeostasis

, 2021
Xiaoyue Cao, Yuke Shu, Yuwei Chen, Qing Xu, Gang Guo, Zhenru Wu, Mingyang Shao, Yongjie Zhou, Menglin Chen, Yuping Gong, Chuan Li, Yujun Shi, Hong Bu   +12 more
openalex   +1 more source

Actin dynamics controlled by IqgC, a RasGAP at the crossroads between the IQGAP and fungal GAP1 families

FEBS Open Bio, EarlyView.
IqgC is a RasGAP from Dictyostelium discoideum. IqgC binds RasG via its RasGAP domain and deactivates it on macroendocytic cups, thereby suppressing the uptake of fluid and particles. IqgC has a positive effect on cell‐substratum adhesion, and its RGCt domain is required for recruitment to ventral foci.
Vedrana Filić, Darija Putar, Lucija Mijanović, Igor Weber   +3 more
wiley   +1 more source

Sal-like protein 4 (SALL4), a stem cell biomarker in liver cancers

, 2012
Tsunekazu Oikawa, Akihide Kamiya, Mikio Zeniya, Hiromi Chikada, Ahn Dong Hyuck, Yuji Yamazaki, Eliane Wauthier, Hisao Tajiri, Lance D. Miller, Xin Wei Wang, Lola M. Reid, Hiromitsu Nakauchi   +11 more
openalex   +2 more sources

Key role for inhibins in effective T cell activation, migration and Th17 differentiation

FEBS Open Bio, EarlyView.
Activins/inhibins modulate immune responses. Here, we show that inhibins can be produced very early after T cell activation and can act in an autocrine way, favoring Th1 versus Th17 differentiation and CCL19/CCL21 mediated migration. Recombinant inhibin A can restore the Th1/Th17 balance, highlighting the role of inhibins as key regulators of T cell ...
Sandra Ortega‐Francisco, Roxana Olguín‐Alor, Lizbeth Bolaños‐Castro, Alexandra Morales‐Cruz, Marisol De La Fuente‐Granada, Gloria Soldevila   +5 more
wiley   +1 more source

Impact of sarcopenia on outcomes of patients undergoing liver resection for hepatocellular carcinoma

, 2022
Jinhuan Yang, Kaiwen Chen, Chongming Zheng, Kaiyu Chen, Jian Lin, Qishan Meng, Ziyan Chen, Liming Deng, Haitao Yu, Tuo Deng, Zhiyuan Bo, Qikuan He, Yi Wang, Gang Chen   +13 more
openalex   +1 more source

Transcriptional regulation of neuropeptide receptors underlies context‐dependent adaptation in Drosophila melanogaster

FEBS Open Bio, EarlyView.
Under environmental changes, the expression level of neuropeptide (NP) and neuropeptide receptor (NPR) genes changes to confer context‐dependent adaptation to the model organism Drosophila melanogaster. Through finding more regulatory elements in the NPR genes in comparison with their ligands (NPs), we found that NPR‐biased transcriptional regulation ...
SeungHeui Ryu, Yanan Wei, Zekun Wu, Tianmu Zhang, DoHoon Lee, Hadi Najafi, Woo Jae Kim   +6 more
wiley   +1 more source

Predicting Resistance and Survival of HCC Patients Post-HAIC: Based on Shapley Additive exPlanations and Machine Learning

Journal of Hepatocellular Carcinoma
Fan Yao,1,2,* Jianliang Miao,3,* Bing Quan,1,2 Jinghuan Li,1,2 Bei Tang,1,2 Shenxin Lu,1,2 Xin Yin1,2 1Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai, People’s Republic of China; 2National Clinical Research Center ...
Yao F, Miao J, Quan B, Li J, Tang B, Lu S, Yin X   +6 more
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