Results 241 to 250 of about 2,769,816 (316)

Outcomes of Liver Transplant Versus Partial Hepatectomy for Perihilar Cholangiocarcinoma Patients Requiring Arterial Reconstruction. [PDF]

Liver Int
Poletto E, Olthof PB, Ruzzenente A, Adam JP, Alwayn IPJ, Boleslawski E, de Boer MT, Chebaro A, Chiche L, Dopazo C, Dubbeld J, Erdmann JI, Hakeem A, Coenraad MJ, Kuipers H, Mabrut JY, Maulat C, Maithel SK, de Meijer VE, Mohkam K, Murad SD, Muscari F, Rolinger J, Polak WG, Rayar M, Ratti F, Robin F, Schnitzbauer AA, Sparrelid E, Van Vilsteren FGI, Porte RJ, Hoogwater FJH, Groot Koerkamp B, Perihilar Cholangiocarcinoma Collaboration Group.   +33 more
europepmc   +1 more source

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

β-Hydroxybutyrate Improves Glucose Metabolism in Streptozotocin-Induced Type 1 Diabetes by Inhibiting Gut and Liver Glucose Transporters via GPR109A. [PDF]

Diabetes
Li S, Wang J, Xin C, Dong Y, Xie A, Song J, Wan J, Yin J.   +7 more
europepmc   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Association of prediabetes phenotypes with metabolic dysfunction-associated fatty liver disease and liver fibrosis: a population-based study. [PDF]

Ther Adv Endocrinol Metab
He M, Liu Y, Gao T, Gu J, Zhou X, Sun Z, Qiu S.   +6 more
europepmc   +1 more source

Evaluating the involvement of autolysosomes in the nuclear translocation of fluorescent proteins

FEBS Open Bio, EarlyView.
Endogenously expressed fluorescent proteins can be degraded by autophagy and transported to cell nuclei via the nuclear pore complex. But in some cell lines, for example, HeLa cells which are positive for immunoreactivity of a receptor ligand, such as UCN I, in cell nuclei, fusion of autolysosome with the nuclear envelope is involved in the nuclear ...
Keiichi Ikeda
wiley   +1 more source

<i>In vitro</i> models of the gut-liver axis: what we've learned and what remains to be built. [PDF]

Front Immunol
Sung JH, Kim R.
europepmc   +1 more source

How phagocytic cells kill bacteria: Lessons from a professional killer

FEBS Open Bio, EarlyView.
How phagocytic cells ingest and kill bacteria has been studied for more than a century, but many questions remain unanswered. The study of the amoeba Dictyostelium discoideum brings new answers, and new questions. Professional phagocytic cells such as neutrophils and macrophages, as well as free‐living soil amoebae like Dictyostelium discoideum, employ
Otmane Lamrabet, Pierre Cosson
wiley   +1 more source

Amoxicillin-Induced Drug-Induced Liver Injury Superimposed on Acute Hepatitis C Infection in a Patient With Hurler Syndrome: A Diagnostic Challenge Assessed by the Updated RUCAM. [PDF]

Case Reports Hepatol
Garg A, Seshie P, Chouthai A, Raval S, Santharaman A, Manzoor A, Broder A.   +6 more
europepmc   +1 more source