Results 141 to 150 of about 1,087,915 (317)

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Liver cancer [PDF]

Nature, 2014
openaire   +2 more sources

Liver cancer stem cells: Implications for a new therapeutic target

, 2009
Hepatocellular carcinoma (HCC) is an aggressive tumour with a poor prognosis. Current therapeutic strategies against this disease target mostly rapidly growing differentiated tumour cells.
Ma, S, Lee, TKW, Ng, IOL, Castilho, A
core   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Stanniocalcin 1 Promotes Metastasis Of Hepatocellular Carcinoma Through Activation Of Jnk Signaling

, 2017
Introduction: The hypoxic tumor microenvironment of hepatocellular carcinoma (HCC) is a major contributor to tumor progression and the aggressive biological behavior of the cancer.
Chan, KS, Chok, KSH, Wong, CCL, Lai, CL, Leung, ON, Ng, IOL, Lo, CLR   +6 more
core  

A genic and epigenetic combination therapy for liver cancer

, 2017
Genetic and epigenetic mechanisms are the baseline of cancer initiation, progression and prognosis. Liver cancer can be the result of viral infections, metabolic disorder, genetic variation/mutation and epigenetic deregulation.
Rinaldi, L., Lastoria, S, V Folliero, R. di Francia, di Francia, R, Palomba, L, LE Adinolfi, L. Palomba, L Rinaldi, L. Rinaldi, Adinolfi, LE, R. Isticato, L Palomba, Ascione, A, A Ascione, I De Sio, G. Morelli, Pedone, C, I. De Sio, null S.Lastoria, L.E. Adinolfi, R di Francia, Folliero, V, Altucci, L, V. Folliero, C. Pedone, Franci, G, G. Franci, L. Altucci, LASTORIA, Maria, C. Zannella, M Galdiero, Zannella, C, Isticato, R, De Sio, I, Morelli, G, FRANCI, Gianluigi, A. Ascione, MORELLI, Giuseppe, R Isticato, Galdiero, M, L Altucci, M. Galdiero, C Zannella, PEDONE, Carlo   +44 more
core   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Hypoxia Inducible Factor-1 (Hif-1)/ Ectonucleoside Triphosphate Diphosphohydrolase 2 (Entpd2) Maintained an Immune-Suppressive Microenvironment in Hepatocellular Carcinoma

, 2017
Introduction: Mortality rate of hepatocellular carcinoma (HCC) is extremely high due to late symptom presentation and lack of curative therapy. Understanding the biology of HCC will accelerate the development of more effective therapies.
Wong, CM, Chiu, DKC, Wong, CCL, Tse, PW, Ng, IOL   +4 more
core