Results 161 to 170 of about 4,753,656 (310)

Artificial intelligence and personalised medicine in liver cancer. [PDF]

J Hepatol
Matuschewski NJ, Baker W, Chapiro J, Calderaro J.   +3 more
europepmc   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Metabolic Signatures for Liver Cancer Diagnosis and Mechanistic Insights: A Large-Scale, Multicenter Study. [PDF]

Adv Sci (Weinh)
Xu Y, Wang J, Ding C, Xia C, Liu Y, Zheng Y, Chang S, Zhang S, He Y, Sun R, Xi Y, Liu Y, Qian K, Chen W.   +13 more
europepmc   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

The Application of Nanomaterials in the Detection of Liver Cancer Biomarkers. [PDF]

Int J Nanomedicine
Qiu D, Cao W, Gao Y, Ma T, Deng W, Wang S, Zhang Y, Wei X, Yao L, Gao Z, Wang S, Li M.   +11 more
europepmc   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Undifferentiated carcinomas in a large animal model of liver cancer. [PDF]

Animal Model Exp Med
Boas FE, Basturk O, Yin Z, Yarmohammadi H, Elkhadragy L, Chiang J, Mohammad IS, Solomon SB.   +7 more
europepmc   +1 more source

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

Significance of local and circulating cancer stem cells in human liver cancer

, 2008
Background: Cancer stem cells (CSCs) have been shown to be the source of many solid tumor types, including cell-line induced hepatocellular carcinoma (HCC).
Fan, ST, Poon, RTP, Ng, MN, Lau, CK, Lam, CT, Yang, Z, Ho, DWY   +6 more
core  

Prevalence and Cure of Primary Liver Cancer in Italy by Histologic Type. [PDF]

Cancers (Basel)
Bucchi L, Ferretti S, Toffolutti F, Fedeli U, Mancini S, Zamagni F, Giudici F, Botta L, Zorzi M, Bidoli E, Cuccaro F, Gasparotti C, Caldarella A, Fusco M, Lanzoni M, Migliore E, Puppo A, Michiara M, Cavallo R, Ferrante M, Sampietro G, Mazzucco W, Cirilli C, Vattiato R, Stracci F, Guarda L, Manzoni F, Mantovani W, Cascone G, Palmonari C, Targa F, Mangone L, Galasso R, Porcheddu A, Pesce MT, Bella F, Seghini P, Fanetti AC, Pinna P, Guzzinati S, Dal Maso L, On Behalf Of The Airtum Working Group.   +41 more
europepmc   +1 more source