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Liver cirrhosis: An overview of experimental models in rodents
Life Sciences, 2022The liver, a component of the gastrointestinal tract, is one of the most important organs in the human body. The liver performs over 500 functions to promote physiological homeostasis. In addition, the liver acts as a screen, by metabolizing substances carried by blood coming from the digestive tract before they enter the systemic circulation.
Lanuza A P, Faccioli +3 more
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Collagenolytic activity in experimental cirrhosis of the liver
Experimental and Molecular Pathology, 1987Collagenolytic activity has been measured in insoluble sediments of normal and CCl4-induced cirrhotic rat liver. Two techniques were used: in one assay, the insoluble liver sediments were incubated with a radioactively labeled exogenous substrate; in the other assay, the endogenous collagen present in the insoluble liver sediments served as the ...
R, Perez-Tamayo +2 more
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EXPERIMENTAL CIRRHOSIS OF THE LIVER
JAMA: The Journal of the American Medical Association, 1913Ever since Laennec 1 first described cirrhosis of the liver, there has been an immense amount of experimental work done as to the etiology and histology of this disease. Joannovics 2 in 1904 gave a summary of the work that had been done up to that time together with a summary of the methods used.
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A morphometric analysis of the hypertrophy of experimental liver cirrhosis
Virchows Archiv A Pathological Anatomy and Histopathology, 1983The objective of this study was to better elucidate the composition of the hypertrophic cirrhotic liver. We induced cirrhosis with hypertrophy in rats by simultaneous treatment with CCl4 and phenobarbital (PB) and devised a hierarchy of structure applicable to the sampling and morphometric analysis of untreated and PB-treated control livers and of ...
J W, Ryoo, R J, Buschmann
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EXPERIMENTAL CIRRHOSIS OF THE LIVER
Journal of the American Medical Association, 1942To the Editor:— We wish to express our appreciation for the recent editorial mention (The Journal, October 24, p. 624) of our studies on experimental cirrhosis of the liver. From this editorial, however, those who are not familiar with the study might infer that the detailed analysis of the dietary factors involved in the pathogenesis of this disease ...
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Development Of An Experimental Model Of Liver Cirrhosis In Rabbits
Clinical and Experimental Pharmacology and Physiology, 2000SUMMARY1. The aim of the present study was to develop an experimental model of liver cirrhosis in rabbits using CCl4 and phenobarbital.2. Liver cirrhosis was induced in male New Zealand white rabbits (n = 10) by intragastric administration of CCl4 once weekly starting 14 days after the addition of phenobarbital to the drinking water (50 mg/day ...
C G, Brandão +6 more
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Intrarenal Alterations in Experimental Liver Cirrhosis
Physiology, 1996In liver cirrhosis, renal reabsorption of water and sodium precedes ascites formation. Reduced renal excretory rates can be found in the absence of changes in plasma levels of main systemic hormones. It is possible that intrarenal elevations of antinatriuretic systems participate in retention of water and sodium in early cirrhosis.
M Atucha, G-E Joaquin
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Erythrocyte catalase in liver cirrhosis and in experimental liver injury
Experientia, 1963Nous avons trouve que l'activite de la catalase des erythrocytes chez les cirrhotiques et chez les chiens intoxiques par CCl4 est considerablement diminuee, tandis que le numero globulaire et le taux d'hemoglobine ne representent que des changements tres peu signicatifs.
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PATHOLOGY OF LIVER CIRRHOSIS IN EXPERIMENTAL SCHISTOSOMIASIS JAPONICA
Acta Pathologica Japonica, 1971Rabbits were experimentally infected with Scbistosoma japonicum to observe morphological alterations of the liver to the 60th week of infection in chronological sequence. In the present report, the developing process of liver cirrhosis due to Schistosoma japonicum was elucidated together with the repairing process occurring after its cirrhotic state ...
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EXPERIMENTAL CIRRHOSIS OF THE LIVER IN PRIMATES
The Lancet, 1959G F, WILGRAM, W J, TAYLOR
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