Results 121 to 130 of about 2,052,006 (381)
The spleen in liver cirrhosis: revisiting an old enemy with novel targets
Journal of Translational Medicine, 2017 The spleen is a secondary lymphoid organ which can influence the progression of multiple diseases, notably liver cirrhosis. In chronic liver diseases, splenomegaly and hypersplenism can manifest following the development of portal hypertension.
Liang Li +6 more
semanticscholar +1 more source
Advanced Science, EarlyView.The study found that RPL6 is frequently upregulated in HCC tissues with extrahepatic metastasis. Elevated RPL6 bound to and increased the stability of HMGCS1 mRNA, thereby enhancing intracellular cholesterol levels. Subsequently, increased cholesterol promotes cancer metastasis in HCC by stabilizing HIF‐1α protein.
Minli Yang +15 more
wiley +1 more source
Transient portal vein thrombosis in liver cirrhosis
BMC Medicine, 2018 In real-world clinical practice, the acceptance of anticoagulation therapy in the management of portal vein thrombosis (PVT) in patients with cirrhosis is limited by the fear of an increased bleeding risk.
Xingshun Qi +11 more
doaj +1 more source
Insertion of LINE-1 Retrotransposon Inducing Exon Inversion Causes a Rotor Syndrome Phenotype
Frontiers in Genetics, 2020 Rotor syndrome, a rare autosomal-recessive genetic disorder characterized by conjugated hyperbilirubinemia, is caused by biallelic pathogenic variants in both SLCO1B1 and SLCO1B3 genes.
Donghu Zhou +49 more
doaj +1 more source
Advanced Science, EarlyView.This study introduces an in situ assembly of fluorogenic RNA approach for screening natural anti‐liver fibrosis compounds and dynamic visualization of endogenous COL1A1 mRNA in live cells. It offers a simple, cost‐effective approach of visualizing RNA dynamics and conducting drug screening in live cells, presenting a significant potential for the ...
Rui Bai +6 more
wiley +1 more source
Frontiers in Genetics, 2019 IntroductionCirrhosis is one of the most important risk factors for development of hepatocellular carcinoma (HCC). Recent studies have shown that removal or well control of the underlying cause could reduce but not eliminate the risk of HCC.
Shan Shan +7 more
doaj +1 more source
Ornipressin in the treatment of functional renal failure in decompensated liver cirrhosis [PDF]
, 1991 In 11 patients with decompensated cirrhosis and deteriorating renal function, the effect of the vasoconstrictor substance 8-ornithin vasopressin (ornipressin; POR 8; Sandoz, Basel, Switzerland) on renal function, hemodynamic parameters, and humoral ...
Alexander L. Gerbes +66 more
core +1 more source
Cancer and liver cirrhosis: implications on prognosis and management
ESMO Open, 2016 Liver cirrhosis, the end-stage of every chronic liver disease, is not only the major risk factor for the development of hepatocellular carcinoma but also a limiting factor for anticancer therapy of liver and non-hepatic malignancies.
M. Pinter +3 more
semanticscholar +1 more source
Advanced Science, EarlyView.This study integrates scRNA‐seq, multiplex immunofluorescence, and clinical data to identify HLA‐DR⁺tumor cells uniquely enriched in Hepatocellular carcinoma (HCC) with hepatitis B virus (HBV). These cells express MHC II, associate with PD‐L1, recruit and exhaust CD8⁺T cells, predict poor survival, and serve as potential biomarkers for immunotherapy ...
Jun‐Qing Chang +17 more
wiley +1 more source
Alcohol consumption and liver cirrhosis mortality: New evidence from a panel data analysis for sixteen European countries [PDF]
Empirical evidence gives strong support to a close association between liver cirrhosis mortality and the intake of alcohol and most often a log-linear relationship is assumed in the econometric modeling.
Bentzen, Jan, Smith, Valdemar
core