Liver cirrhosis in England--an observational study: are we measuring its burden occurrence correctly? [PDF]
Objectives: Mortality due to liver disease (of which cirrhosis is the end‐stage) is increasing more than any other chronic condition in the UK. This study aims to demonstrate that (i) exclusive reliance on mortality rates may not reveal the true burden ...
Blachier+18 more
core +1 more source
Hyponatremia can worsen the outcomes of patients with liver cirrhosis. However, it remains unclear about how to predict the risk of death in cirrhotic patients with hyponatremia. Patients with liver cirrhosis and hyponatremia were screened.
Zhaohui Bai+4 more
doaj +1 more source
Therapeutic effects of serum extracellular vesicles in liver fibrosis
The lack of approved therapies for hepatic fibrosis seriously limits medical management of patients with chronic liver disease. Since extracellular vesicles (EVs) function as conduits for intercellular molecular transfer, we investigated if EVs from ...
Li Chen+5 more
doaj +1 more source
A Joint Deep Learning Approach for Automated Liver and Tumor Segmentation [PDF]
Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer in adults, and the most common cause of death of people suffering from cirrhosis. The segmentation of liver lesions in CT images allows assessment of tumor load, treatment planning, prognosis and monitoring of treatment response.
arxiv
Neuropsychiatric performance and treatment of hepatitis C with direct-acting antivirals: a prospective study [PDF]
Background: Since direct-acting antivirals (DAAs) have been approved for the treatment of hepatitis C virus (HCV) infection, a small series of patients with new-onset neuropsychiatric alterations have been referred to us.
Amodio, Piero+11 more
core +1 more source
Cancer and liver cirrhosis: implications on prognosis and management
Liver cirrhosis, the end-stage of every chronic liver disease, is not only the major risk factor for the development of hepatocellular carcinoma but also a limiting factor for anticancer therapy of liver and non-hepatic malignancies.
M. Pinter+3 more
semanticscholar +1 more source
Transient portal vein thrombosis in liver cirrhosis
In real-world clinical practice, the acceptance of anticoagulation therapy in the management of portal vein thrombosis (PVT) in patients with cirrhosis is limited by the fear of an increased bleeding risk.
Xingshun Qi+11 more
doaj +1 more source
Insertion of LINE-1 Retrotransposon Inducing Exon Inversion Causes a Rotor Syndrome Phenotype
Rotor syndrome, a rare autosomal-recessive genetic disorder characterized by conjugated hyperbilirubinemia, is caused by biallelic pathogenic variants in both SLCO1B1 and SLCO1B3 genes.
Donghu Zhou+49 more
doaj +1 more source
A Circulating Biomarker-based Framework for Diagnosis of Hepatocellular Carcinoma in a Clinically Relevant Model of Non-alcoholic Steatohepatitis; An OAD to NASH [PDF]
Although cirrhosis is a key risk factor for the development of hepatocellular carcinoma (HCC), mounting evidence indicates that in a subset of patients presenting with non-alcoholic steatohepatitis (NASH), HCC manifests in the absence of cirrhosis. Given the sheer size of the non-alcoholic fatty liver disease (NAFLD) epidemic, and the dismal prognosis ...
arxiv
Intrarenal Resistance Index as a Prognostic Parameter in Patients with Liver Cirrhosis Compared with Other Hepatic Scoring Systems [PDF]
Background and Aims: Patients with advanced liver cirrhosis who develop renal dysfunction have a poor prognosis. Elevated intrarenal resistance indices (RIs) due to renal vascular constriction have been described before in cirrhotic patients.
Bardi A+14 more
core +1 more source