Results 221 to 230 of about 2,061,642 (403)
ESC Heart Failure, EarlyView.Abstract Aims Targeting inflammasomes in heart failure (HF) might represent a novel therapeutic option. Nevertheless, previous studies focused only on myocardial inflammasome alterations, and data are scarce regarding their regulation and role in HF‐associated multiorgan dysfunction.
Dávid Nagy +12 more
wiley +1 more source
Hepatology, EarlyView., 2022 Diagnostic and prognostic ability of urinary NGAL in patients with cirrhosis and AKI. Abstract Background and Aims Acute kidney injury (AKI) commonly occurs in patients with decompensated cirrhosis. Urinary neutrophil gelatinase–associated lipocalin (uNGAL) could help discriminate between different etiologies of AKI.
Carmine Gambino +14 more
wiley +1 more source
A Case of Congenital Cirrhosis of the Liver with Renal Tubular Defects Akin to Those in the Fanconi Syndrome [PDF]
, 1956 Michael Baber
openalex +1 more source
ESC Heart Failure, EarlyView.Abstract Aims Sarcopenia is a major comorbidity in heart failure (HF) patients, but its comprehensive evaluation remains challenging due to resource limitations. Computed tomography (CT) imaging allows opportunistic assessment of both muscle quantity and quality; however, its diagnostic utility and relationships with physical performance and underlying
Wataru Kawaharata +13 more
wiley +1 more source
TP53 R249S mutation in hepatic organoids captures the predisposing cancer risk
Hepatology, EarlyView., 2022 The systematic approach in elucidating the gain‐of‐function (GOF) roles of TP53 mutations in early liver carcinogenesis. Unique downstream targets of TP53 L3 mutations were identified from chormatin immunoprecipitation sequencing in HCC cell lines, followed by a series of validation assays to substantiate the exclusive transcriptional regulations ...
Yin Kau Lam +10 more
wiley +1 more source
Therapeutic approaches for liver fibrosis/cirrhosis by targeting pyroptosis
Open Life SciencesLong-term repeated exposure to various stimuli leads to chronic liver damage, inflammation, fibrosis, and eventually cirrhosis. Pyroptosis, a mode of inflammatory programed cell death, affects the progression of liver fibrosis/cirrhosis. However, current
Qiao Guanen +6 more
doaj +1 more source
SUPPRESSION OF SODIUM EXCRETION BY THE COLON IN CONGESTIVE HEART FAILURE AND CIRRHOSIS OF THE LIVER DEMONSTRATED BY THE USE OF CATION EXCHANGE RESINS 1 [PDF]
, 1952 Eugene Y. Berger +3 more
openalex +1 more source
ESC Heart Failure, EarlyView.This systematic review identified 24 clinical trials of medical device and surgical interventions for HFpEF, with 16 demonstrating at least safety and feasibility, but little evidence of long‐term benefit. Phenotype‐based responses suggest that certain interventions may benefit specific HFpEF subgroups, yet most trials suffered from heterogeneous ...
Kurdo Araz +5 more
wiley +1 more source