Results 261 to 270 of about 410,300 (316)

Evaluation of the Pharmacokinetics, Disposition, and Metabolism of Miricorilant, a Novel Glucocorticoid Receptor Modulator for the Treatment of Metabolic Dysfunction‐Associated Steatohepatitis in Nonclinical and Clinical Studies

The Journal of Clinical Pharmacology, EarlyView.
Abstract Miricorilant is a novel selective glucocorticoid receptor (GR) modulator with mixed agonist/antagonist effects at the GR and modest antagonism at the mineralocorticoid receptor that is being developed for the treatment of metabolic dysfunction‐associated steatohepatitis.
Hazel J. Hunt, Kirsteen M. Donaldson, Jeevan R. Kunta, Joseph M. Custodio   +3 more
wiley   +1 more source

Role of endoscopy in the diagnosis and treatment of gastric mucosal lesions in liver cirrhosis patients. [PDF]

World J Gastrointest Endosc
Olevskaya ER, Dolgushina AI, Garbuzenko DV, Khikhlova AO, Saenko AA, Khusainova GM, Kuznetsova AS.   +6 more
europepmc   +1 more source

In Vitro and Clinical Evaluation of Potential Interactions of Bemnifosbuvir with Drug Transporters

The Journal of Clinical Pharmacology, EarlyView.
Abstract Bemnifosbuvir is a novel oral guanosine nucleotide prodrug candidate for the treatment of chronic hepatitis C virus infection. Potential drug–drug interactions (DDIs) of bemnifosbuvir as a substrate or perpetrator with regard to ATP‐binding cassette (ABC) and solute carrier (SLC) transporters were evaluated in vitro and in clinical studies ...
Xiao‐Jian Zhou, Alex Vo, Gaetano Morelli, Maureen Montrond, Shannan Lynch, Keith Pietropaolo, Bruce Belanger, Arantxa Horga, Nancy Agrawal, Janet Hammond   +9 more
wiley   +1 more source

Clinical impact of multidrug-resistant organisms in liver cirrhosis: A retrospective cohort study in the intensive care setting. [PDF]

World J Gastroenterol
Kosuta I, Babel J, Domislovic V, Susak F, Peretin L, Varda Brkic D, Marekovic I, Radonic R, Mrzljak A.   +8 more
europepmc   +1 more source

Outcomes of Patients With Unresectable Cholangiocarcinoma After Portal Vein Embolization: A Propensity Score‐Matched Analysis

Journal of Hepato-Biliary-Pancreatic Sciences, EarlyView.
ABSTRACT Background This study aimed to evaluate the outcomes of patients with unresectable cholangiocarcinoma (CCA) who underwent portal vein embolization (PVE) with a focus on overall survival (OS) and the frequency of biliary drainage (BD). Methods In this retrospective analysis, we evaluated 255 patients with unresectable CCA; 56 patients underwent
Ho Seung Lee, Tae Jun Song, Sung Hyun Cho, Gunn Huh, Dongwook Oh, Jae Min Lee, Jae Hoon Lee, Dae Wook Hwang, Dong‐Wan Seo   +8 more
wiley   +1 more source

Risk Factors and Strategies for Failure to Rescue Following Hepatectomy: A Review

Journal of Hepato-Biliary-Pancreatic Sciences, EarlyView.
ABSTRACT Failure to rescue (FTR), defined as mortality after major postoperative complications, is a crucial indicator of surgical quality. Although mortality rates after hepatectomy have declined owing to improved surgical techniques and perioperative care, FTR remains a major concern.
Jiro Kimura, Kosei Takagi, Tomokazu Fuji, Kazuya Yasui, Takeyoshi Nishiyama, Toshiyoshi Fujiwara   +5 more
wiley   +1 more source

Skeletal muscle abnormalities negatively linked to sleep disturbances in patients with liver cirrhosis: a cross-sectional study. [PDF]

Eur J Med Res
Yao S, Peng B, Liu W, Yang J, Hui Y, Sun C.   +5 more
europepmc   +1 more source

Early Definitive Surgery for Congenital Biliary Dilatation in Children Is Associated With Lower Morbidity: Comparison of Infant and School‐Age Children From 231 Consecutive Cases in a Multicenter Study in the Kyushu Area of Japan During the Past Decade

Journal of Hepato-Biliary-Pancreatic Sciences, EarlyView.
ABSTRACT Purpose There has been little discussion on the differences in characteristics and long‐term outcomes of congenital biliary dilation (CBD) by age group. Methods We conducted a regional multicenter study to investigate all pediatric cases of CBD in the Kyushu area of Japan over the past decade.
Masakazu Murakami, Koshiro Sugita, Shohei Maeda, Kina Miyoshi, Yusuke Yamane, Taichiro Kosaka, Shun Onishi, Makoto Hayashida, Toshiharu Matsuura, Kimio Asagiri, Motofumi Torikai, Yukihiro Tatekawa, Takeshi Yamanouchi, Taizo Hibi, Tatsuro Tajiri, Satoshi Ieiri   +15 more
wiley   +1 more source

The effects of empagliflozin on diuresis and natriuresis in patients with type 2 diabetes mellitus and liver cirrhosis. [PDF]

Ann Gastroenterol
Siafarikas C, Kapelios CJ, Papatheodoridi M, Cholongitas E, Androutsakos T, Vlachogiannakos J, Tentolouris N, Papatheodoridis G.   +7 more
europepmc   +1 more source