Results 41 to 50 of about 2,100,798 (313)
Alcoholic liver cirrhosis, more than a simple hepatic disease – A brief review of the risk factors associated with alcohol abuse [PDF]
, 2019 Liver cirrhosis is a significant public health problem, being an important cause of mortality and morbidity, responsible for approximately 1.8% of the total number of deaths in Europe.
Andrada, Dumitru +10 more
core +2 more sources
Advanced Science, 2021 Intrahepatic cholangiocarcinoma (ICC) is highly heterogeneous. Here, the authors perform exome sequencing and bulk RNA sequencing on 73 tumor regions from 14 ICC patients to portray the multi‐faceted intratumor heterogeneity (ITH) landscape of ICC.
Xiao Xiang +14 more
doaj +1 more source
Pipeline for precise insoluble matrisome coverage in tissue extracellular matrices
Frontiers in Bioengineering and Biotechnology, 2023 The extracellular matrix (ECM) is assembled by hundreds of proteins orchestrating tissue patterning and surrounding cell fates via the mechanical–biochemical feedback loop.
Wei Chen +11 more
doaj +1 more source
Immunotherapy in hepatocellular carcinoma: the complex interface between inflammation, fibrosis, and the immune response. [PDF]
, 2019 Hepatocellular carcinoma (HCC) is the third leading cause of cancer deaths worldwide and confers a poor prognosis. Beyond standard systemic therapy with multikinase inhibitors, recent studies demonstrate the potential for robust and durable responses ...
Fong, Lawrence +2 more
core +2 more sources
Spontaneous porto-systemic shunts in liver cirrhosis: Clinical and therapeutical aspects
World Journal of Gastroenterology, 2020 Spontaneous porto-systemic shunts (SPSS) are frequent in liver cirrhosis and their prevalence increases as liver function deteriorates, probably as a consequence of worsening portal hypertension, but without achieving an effective protection against ...
S. Nardelli +5 more
semanticscholar +1 more source
Stem Cell Research & Therapy, 2017 Background Although they are expandable in vitro, hepatic progenitors are immature cells and share many immunomarkers with hepatocellular carcinoma, raising potential concerns regarding maltransformation after transplantation. This study investigated the
Ping Wang +13 more
doaj +1 more source
Stem Cell Research & Therapy, 2022 Background Acetaminophen (APAP) overdose is a major cause of the morbidity of acute liver failure. The current clinically approved treatment for APAP poisoning, N-acetylcysteine (NAC), has a limited therapeutic window, and prolonged treatment with NAC ...
Ping Wang +15 more
doaj +1 more source
Telomere shortening as genetic risk factor of liver cirrhosis [PDF]
, 2015 Cirrhosis is the main complication of chronic liver disease, leads to progressive liver function impairment and is the main risk factor for the development of liver cancer.
Carulli, Lucia
core +1 more source
A validation study of the CirCom comorbidity score in an English cirrhosis population using the Clinical Practice Research Datalink [PDF]
, 2018 Purpose: The CirCom score has been developed from Danish data as a specific measure of comorbidity for cirrhosis to predict all-cause mortality. We compared its performance with the Charlson Comorbidity Index (CCI) in an English cirrhosis population ...
Crooks, Colin J. +2 more
core +3 more sources
Gastroenterology Research and Practice, 2015 Background and Aims. A retrospective cross-sectional study was conducted to evaluate the role of hyaluronic acid (HA), laminin (LN), amino-terminal propeptide of type III procollagen (PIIINP), and collagen IV (CIV) in predicting the presence of ...
Xingshun Qi +9 more
doaj +1 more source