Results 141 to 150 of about 12,874,292 (410)
Targeting of PTP4A3 overexpression sensitises HGSOC cells towards chemotherapeutic drugs
Molecular Oncology, EarlyView.In HGSOC with normal KRAS expression, high PTP4A3 expression regulates autophagy activation. Conversely, in HGSOC with high KRAS expression, KRAS dictates autophagy control, and PTP4A3 is not required. When high PTP4A3 expression is inhibited, HGSOC cells are preferentially sensitised towards DNA‐damaging agents.
Ana López‐Garza +3 more
wiley +1 more source
Myocardial ischemia after orthotopic liver transplantation [PDF]
, 1994 A hypercoagulable state exists after orthotopic liver transplantation. This hematologic abnormality may predispose patients to coronary thrombosis and unstable angina.
Ambrose +24 more
core +1 more source
Decrypting cancer's spatial code: from single cells to tissue niches
Molecular Oncology, EarlyView.Spatial transcriptomics maps gene activity across tissues, offering powerful insights into how cancer cells are organised, switch states and interact with their surroundings. This review outlines emerging computational, artificial intelligence (AI) and geospatial approaches to define cell states, uncover tumour niches and integrate spatial data with ...
Cenk Celik +4 more
wiley +1 more source
Mechanisms and disease consequences of nonalcoholic fatty liver disease
Cell, 2021 R. Loomba, S. Friedman, G. Shulman
semanticscholar +1 more source
Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology
Molecular Oncology, EarlyView.Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts +8 more
wiley +1 more source
Weil's Disease, with Tests for Liver Function [PDF]
, 1949 F. E. d. W. Cayley
openalex +1 more source
New Perspectives on Treatment of Hepatitis B Before and After Liver Transplantation [PDF]
, 2016 open5noThe hepatitis B virus (HBV) infects more than 260 million people globally, with increasing incidence, especially in developing countries.
Bortoluzzi, Ilaria +4 more
core +1 more source
Molecular Oncology, EarlyView.A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira +14 more
wiley +1 more source
Molecular mechanisms of hepatic lipid accumulation in non-alcoholic fatty liver disease
Cellular and Molecular Life Sciences, 2018 Non-alcoholic fatty liver disease (NAFLD) is currently the world’s most common liver disease, estimated to affect up to one-fourth of the population.
D. H. Ipsen +2 more
semanticscholar +1 more source
OBSERVATIONS ON THE PLASMA PROTHROMBIN AND THE EFFECTS OF VITAMIN K IN PATIENTS WITH LIVER OR BILIARY TRACT DISEASE 1 [PDF]
, 1940 Frederick J. Pohle, John K. Stewart
openalex +1 more source