Results 231 to 240 of about 3,036,447 (259)

High Prevalence of Protective HSD17B13 Variant in Taiwan: An Analysis in Morbidly Obese Individuals and Liver Donors. [PDF]

Genes (Basel)
Lin HY, Tseng HY, Lin CC, Tzeng WJ, Hou TY, Li WF, Lin YC, Yin SM, Wang CC, Liu YY, Lin YH.   +10 more
europepmc   +1 more source

RBM25 Drives Hepatocellular Carcinoma Progression by Stabilizing YAP Through Regulating Oncogenic Splicing‐switch of MYPT1

Advanced Science, EarlyView.
This study establishes that the RBM25‐PRPF40A interaction modulates MYPT1 splicing, promoting the production of the oncogenic long isoform. This isoform stabilizes YAP by suppressing its phosphorylation and subsequent proteasomal degradation, ultimately accelerating tumor growth.
Wenjing Zhang, Lili Zhi, Tian Huang, Lingya Feng, Chaoqun Chen, Huanhuan Wei, Xiaolong Liu, Lei Chen, Jinrui Zhang, Ge Zhang, Baofeng Zhao, Rong Liu, Dan Chen, Yangfan Qi, Yang Wang   +14 more
wiley   +1 more source

HEALTH-RELATED QUALITY OF LIFE IN CHRONIC LIVER DISEASE: CLINICAL BURDEN, DETERMINANTS, AND IMPLICATIONS FOR PATIENT-CENTERED CARE. [PDF]

Arq Gastroenterol
Dezan MGF, Hora CPGD, Lyra CR, Cavalcante LN, Cotrim HP, Lyra AC.   +5 more
europepmc   +1 more source

PLXDC2 siRNA‐Mediated Intervention Attenuates Microglial Senescence Through cGAS‐STING Signaling

Advanced Science, EarlyView.
PLXDC2 was identified as a microglial target in Parkinson's disease through human and mouse single‐cell analyses. Ferritin‐armed biomimetic nanovesicles delivered PLXDC2 siRNA, deferoxamine, and CeO2 nanoparticles across the blood–brain barrier, reducing cGAS‐STING activation, iron burden, oxidative stress, and senescence in microglia, thereby ...
Heyue Lu, Zitian Zheng, Feiran Wang, Huanhuan Luo, Fei Ju, Yucheng Zhu, Zheng Zhou, Jie Sun, Zhenghui Qiu, Xiang Luo, Zhongzheng Jia, Jianquan Wang, Hongjie Huang, Bo Zhang   +13 more
wiley   +1 more source

Association between sleep-disordered breathing and liver outcomes in steatotic liver disease: a systematic review and meta-analysis. [PDF]

Front Med (Lausanne)
Alhajery MA, Alotay AA.
europepmc   +1 more source

A Gut‐Brain Axis Underlying Succinate‐Associated Compulsive‐Like Behavior

Advanced Science, EarlyView.
Gut‐derived succinate is associated with an excitatory‐inhibitory imbalance in dmPFC glutamatergic neurons, involving microglial SUCNR1 activation and vagal afferent signaling via upregulated gut 5‐HT4 receptors along the DVC‐CeA‐dmPFC circuit, changes that are linked to excessive compulsive‐like behavior.
Yi Li, Ying‐Dan Zhang, Wei Wang, Xin‐Yi Wu, Di Li, Xin Gong, Fei Tian, Meng‐Yu Dai, Jian Gao, Zi‐Feng Zheng, Zi‐Yang Bi, Dong‐Dong Shi, Zhen Wang   +12 more
wiley   +1 more source

Iron-Sulfur Cluster Targeting: A Novel Perspective for Treating Alcohol-Related Lipid Metabolic Diseases. [PDF]

J Biochem Mol Toxicol
Xu L, Xu Z, Su C, Zhao Y, Qiang L, Jing X, Sun Y.   +6 more
europepmc   +1 more source

The association between oral hygiene and metabolic dysfunction-associated steatotic liver disease - a systematic review. [PDF]

BMC Oral Health
Gerold A, Walter FS, Waller J, Ferger B.
europepmc   +1 more source

Nor-ursodeoxycholic acid in hepatobiliary diseases: A narrative review. [PDF]

World J Gastrointest Pharmacol Ther
Malakar S, Sood N, Giri S, Samanta A.
europepmc   +1 more source

National trends and disparities in alcoholic liver disease mortality, United States, 1999-2024. [PDF]

Medicine (Baltimore)
Yu R, Wang K, Yang K, Li X, Ku X, Sun S, Fan S, Shen J, Zhang T, Fu C, Chen X.   +10 more
europepmc   +1 more source