Results 91 to 100 of about 1,097,318 (312)
Molecular Oncology, EarlyView.C–C chemokine receptor type 9 (CCR9) is an immune checkpoint in pancreatic ductal adenocarcinoma (PDAC). Novel anti‐CCR9 antibody SRB2 was evaluated in combination with cytotoxic chemotherapy in PDAC cells, patient‐derived organoids, patient‐derived xenografts, and humanized mouse models.
Hannah G. McDonald +18 more
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AMMONIUM TOLERANCE IN LIVER DISEASE: OBSERVATIONS BASED ON CATHETERIZATION OF THE HEPATIC VEINS [PDF]
, 1955 Laurens P. White +4 more
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The Treatment of Liver Disease
AJN, American Journal of Nursing, 1953 LVER disease is increasing. Whereas previously it was seen mostly in conjunction with alcoholism or malnutrition, or as a complication of cholecystitis and cholelithiasis, additional causative factors are recognized today. The wide spread epidemic hepatitis of World War II, for instance, produced a sporadic inoculation of persons hitherto never exposed
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Molecular Oncology, EarlyView.TRIM24 and TRIM28 are androgen receptor (AR) coregulators which exhibit increased expression with cancer progression. Both TRIM24 and TRIM28 combine to influence the response of castrate‐resistant prostate cancer (CRPC) cells to AR inhibitors by mediating AR signalling, regulation of MYC and upregulating VEGF to promote angiogenesis. Castrate‐resistant
Damien A. Leach +8 more
wiley +1 more source
OBSERVATIONS ON THE PLASMA PROTHROMBIN AND THE EFFECTS OF VITAMIN K IN PATIENTS WITH LIVER OR BILIARY TRACT DISEASE 1 [PDF]
, 1940 Frederick J. Pohle, John K. Stewart
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Medical Clinics of North America, 1989 Alcohol has been implicated in the genesis of liver disease for centuries. Significant progress has been made in our understanding of the pathogenesis of ALD. It is now apparent that both the consumption and the metabolism of alcohol promote the production of inflammatory mediators (cytokines) that result in hepatotoxicity and fibrogenesis.
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Molecular Oncology, EarlyView.A DIA‐MS‐based proteomics analysis of serum samples from GB patients and healthy controls showed that high levels of IL1R2 and low levels of CRTAC1 and HRG in serum are associated with poor survival outcomes for GB patients. These circulating proteins could serve as biomarkers for the prediction of outcome in patients with GB.
Anne Clavreul +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Cotargeting EGFR and STAT3 with Erlotinib and TTI‐101 impairs both 2D and 3D growth of ETV1‐overexpressing prostate cancer cells by disrupting a self‐sustaining ETV1–EGFR positive feedback loop that promotes EGFR and STAT3 expression and phosphorylation (activation).
Elsa Gomes Paiva +5 more
wiley +1 more source