Results 101 to 110 of about 12,320,543 (412)

The role and implications of mammalian cellular circadian entrainment

FEBS Letters, EarlyView.
At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
wiley   +1 more source

Isoniazid and Rifampicin Produce Hepatic Fibrosis through an Oxidative Stress-Dependent Mechanism

International Journal of Hepatology, 2020
Background & Aims. Chronic hepatitis (CH) has emerged as a distinct outcome of drug-induced liver injury (DILI). Combination therapy of Isoniazid (INH) and Rifampicin (RMP) which is widely used for prolonged periods can cause acute hepatotoxicity and has
Ayan Biswas, Suman Santra, Debasree Bishnu, Gopal Krishna Dhali, Abhijit Chowdhury, Amal Santra   +5 more
doaj   +1 more source

Molecular bases of circadian magnesium rhythms across eukaryotes

FEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

Non-Alcoholic Fatty Liver Disease in Lean and Non-Obese Individuals: Current and Future Challenges [PDF]

, 2021
Mohammad Shafi Kuchay, José Ignacio Martínez‐Montoro, Narendra S. Choudhary, José Carlos Fernández‐García, Bruno Ramos‐Molina   +4 more
openalex   +1 more source

Liver physiology and liver diseases in the elderly

World Journal of Gastroenterology, 2013
The liver experiences various changes with aging that could affect clinical characteristics and outcomes in patients with liver diseases. Both liver volume and blood flow decrease significantly with age. These changes and decreased cytochrome P450 activity can affect drug metabolism, increasing susceptibility to drug-induced liver injury.
Kazuto, Tajiri, Yukihiro, Shimizu
openaire   +2 more sources

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Impact of major duodenal papilla morphology on the outcomes of primary needle-knife fistulotomy for deep biliary cannulation

Scientific Reports
The morphology of the major duodenal papilla (MDP) plays a crucial role in the selection of the cannulation technique. Primary needle-knife fistulotomy (pNKF) is an advanced cannulation technique is getting more popular because of the lower risk of post ...
Amir Sadeghi, Erfan Arabpour, Reyhaneh Rastegar, Samareh Omidvari, Mehdi Azizmohammad Looha, Masoumeh Keshavarzian, Mohammad Reza Zali   +6 more
doaj   +1 more source

Relationship between ureB Sequence Diversity, Urease Activity and Genotypic Variations of Different Helicobacter pylori Strains in Patients with Gastric Disorders [PDF]

Polish Journal of Microbiology, 2016
Association of the severity of Helicobacter pylori induced diseases with virulence entity of the colonized strains was proven in some studies. Urease has been demonstrated as a potent virulence factor for H. pylori.
Hossein Ghalehnoei, Alireza Ahmadzadeh, Nastaran Farzi, Masoud Alebouyeh, Hamid Asadzadeh Aghdaei, Pedram Azimzadeh, Mahsa Molaei, Mohammad Reza Zali   +7 more
doaj   +1 more source

The Role of Oxidative Stress and Antioxidants in Liver Diseases

International Journal of Molecular Sciences, 2015
A complex antioxidant system has been developed in mammals to relieve oxidative stress. However, excessive reactive species derived from oxygen and nitrogen may still lead to oxidative damage to tissue and organs.
Sha Li, H. Tan, Ning Wang, Zhangjin Zhang, L. Lao, C. Wong, Yibin Feng   +6 more
semanticscholar   +1 more source

Ferroptosis in Liver Diseases: An Overview

International Journal of Molecular Sciences, 2020
Ferroptosis is an iron-dependent form of cell death characterized by intracellular lipid peroxide accumulation and redox imbalance. Ferroptosis shows specific biological and morphological features when compared to the other cell death patterns.
M. Capelletti, H. Manceau, H. Puy, K. Peoc’h   +3 more
semanticscholar   +1 more source