Results 171 to 180 of about 12,203,194 (406)

Alcoholic Liver Disease

Medical Clinics of North America, 1989
Alcohol has been implicated in the genesis of liver disease for centuries. Significant progress has been made in our understanding of the pathogenesis of ALD. It is now apparent that both the consumption and the metabolism of alcohol promote the production of inflammatory mediators (cytokines) that result in hepatotoxicity and fibrogenesis.
openaire   +3 more sources

The ACCEPTance of automation: refining circulating tumor cells enumeration for improved metastatic colorectal cancer prognosis

Molecular Oncology, EarlyView.
This study highlights the potential of automated enumeration using the ACCEPT software to refine circulating tumor cell (CTC) detection in metastatic colorectal cancer (mCRC). The automated method demonstrates improved accuracy and reduced variability compared to the manual approach.
Michela De Meo, Marco Siringo, Alessandro Vici, Ann Zeuner, Orietta Gandini, Paola Gazzaniga, Chiara Nicolazzo   +6 more
wiley   +1 more source

The nature of the fatty acids stored by the liver in the fat-deficiency disease of rats [PDF]

, 1938
Leslie Charles Alfred Nunn, Ida Smedley-Maclean   +1 more
openalex   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

AMMONIUM TOLERANCE IN LIVER DISEASE: OBSERVATIONS BASED ON CATHETERIZATION OF THE HEPATIC VEINS [PDF]

, 1955
Laurens P. White, Elizabeth A. Phear, W.H.J. Summerskill, Sheila Sherlock, M. J. Cole   +4 more
openalex   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Correction to: B7-H3 promotes aggression and invasion of hepatocellular carcinoma by targeting epithelial-to-mesenchymal transition via JAK2/STAT3/Slug signaling pathway

Cancer Cell International, 2021
Fu-biao Kang, Ling Wang, Heng-chuan Jia, Dong Li, Hai-jun Li, Yin-ge Zhang, Dian-xing Sun   +6 more
doaj   +1 more source

THE BASAL METABOLISM AND THE SPECIFIC DYNAMIC ACTION OF PROTEIN IN LIVER DISEASE [PDF]

, 1921
Joseph C. Aub
openalex   +1 more source

The diagnosis and management of nonalcoholic fatty liver disease: Practice guidance from the American Association for the Study of Liver Diseases

Hepatology, 2018
N. Chalasani, Z. Younossi, J. Lavine, M. Charlton, K. Cusi, M. Rinella, S. Harrison, E. Brunt, A. Sanyal   +8 more
semanticscholar   +1 more source

Autophagy in liver diseases: A review.

Molecular Aspects of Medicine, 2021
Hui Qian, Xiaojuan Chao, Jessica A. Williams, Sam Fulte, Tiangang Li, Ling Yang, W. Ding   +6 more
semanticscholar   +1 more source