Results 111 to 120 of about 849,982 (299)

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Effect of Milk Drinking on the Level of Liver Enzymes among Workers of Paint Manufacturing Industry [PDF]

طب کار, 2011
Background: Aromatic solvents widely have a wide range of usage in various industries. A great number of epidemiologic studies show the liver toxicity resulting from exposing to organic solvents and their effect on liver transaminases.
MA Vahdani manesh, V Abolhasannejad, N Moasheri, D Ketabi   +3 more
doaj   +2 more sources

Exploring the Association between Elevated Liver Enzymes and Diabetes in the PERSIAN Guilan Cohort Study [PDF]

Caspian Journal of Internal Medicine
Background: Diabetes mellitus (DM) is highly consequential to global health among chronic diseases. Due to a limited researches that have examined relationships between liver enzymes and DM, this study aimed to investigate the link between elevated liver
Mohammad Taghi Ashoobi, Farahnaz Joukar, Kourosh Mojtahedi, Saman Maroufizadeh, Mohammadreza Javid, Ali Parvaneh, Tahereh Zeinali, Niloofar Faraji, Mohammadreza Naghipour, Fariborz Mansour-Ghanaei   +9 more
doaj  

Association of serum 25-hydroxyvitamin D Levels and liver enzymes in a nationally representative sample of iranian adolescents: The childhood and adolescence surveillance and prevention of adult noncommunicable disease study

International Journal of Preventive Medicine, 2018
Background: Hypovitaminosis D is highly prevalent and has several adverse health effects. This study aims to assess the relationship of serum concentrations of 25-hydroxyvitamin D (25[OH] D) and liver enzymes in adolescents.
Maryam Bahreynian, Mostafa Qorbani, Mohammad Esmaeil Motlagh, Ramin Heshmat, Majid Khademian, Roya Kelishadi   +5 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

A Network of SLC and ABC Transporter and DME Genes Involved in Remote Sensing and Signaling in the Gut-Liver-Kidney Axis. [PDF]

, 2019
Genes central to drug absorption, distribution, metabolism and elimination (ADME) also regulate numerous endogenous molecules. The Remote Sensing and Signaling Hypothesis argues that an ADME gene-centered network-including SLC and ABC "drug" transporters,
Bush, Kevin T, Nigam, Sanjay K, Rosenthal, Sara Brin   +2 more
core   +1 more source

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source

Association between liver enzymes and type 2 diabetes: a real-world study

Frontiers in Endocrinology
AimThis study aimed to examine the association of liver enzymes, including alanine aminotransferase (ALT), aspartate aminotransferase (AST), and gamma-glutamyl-transferase (GGT), with type 2 diabetes (T2D) risk, particularly their dose-response ...
Yaru Bi, Yang Yang, Xiaojie Yuan, Jiping Wang, Tuo Wang, Zhiyuan Liu, Suyan Tian, Chenglin Sun   +7 more
doaj   +1 more source

Triacylglycerol synthesis in rat adipose tissue : a thesis presented in partial fulfilment of the requirements for the degree of Master of Science in Biochemistry at Massey University [PDF]

, 1983
Adipose tissue consists of two types of cell; the adipocyte and the non-adipocyte {Rodbell, 1964). The adipocyte is unique amongst mammalian cell types in that one class of component {TG) comprises up to 80% of its weight.
Wilson, Russell Douglas
core