Results 121 to 130 of about 1,826,226 (307)

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Prevalence of elevated liver enzymes and its associated factors among people living with HIV on dolutegravir-based ART at Debre Markos Comprehensive Specialized Hospital, Ethiopia

Scientific Reports
Elevated liver enzymes remain a clinically important adverse effect of antiretroviral therapy (ART) in people living with HIV (PLHIV). Although dolutegravir (DTG)–based ART is recommended as first-line therapy in Ethiopia, evidence on the burden and ...
Mohammed Jemal, Melkamu Tilahun, Tabarak Malik, Belayneh Yosef, Adane Adugna   +4 more
doaj   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Dietary intervention induces flow of changes within biomarkers of lipids, inflammation, liver enzymes, and glycemic control

, 2011
To determine how changes in lipids, liver enzymes, and inflammatory and glycemia markers intercorrelate during prolonged dietary intervention in obese participants with or without type 2 diabetes (T2D)
Harman-Boehm, Ilana, Golan, Rachel, Thiery, Joachim, Matthias Blüher, Tirosh, Amir, Blüher, Matthias, Georg Martin Fiedler, Ilana Harman-Boehm, Joachim Thiery, Michael Stumvoll, Iris Shai, Fiedler, Georg Martin, Amir Tirosh, Stumvoll, Michael, Shai, Iris, DIRECT Group,, Schwarzfuchs, Dan, Rachel Golan, Dan Schwarzfuchs   +18 more
core   +1 more source

Association between liver enzymes and type 2 diabetes: a real-world study

Frontiers in Endocrinology
AimThis study aimed to examine the association of liver enzymes, including alanine aminotransferase (ALT), aspartate aminotransferase (AST), and gamma-glutamyl-transferase (GGT), with type 2 diabetes (T2D) risk, particularly their dose-response ...
Yaru Bi, Yang Yang, Xiaojie Yuan, Jiping Wang, Tuo Wang, Zhiyuan Liu, Suyan Tian, Chenglin Sun   +7 more
doaj   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Small RNA pathways in mammalian oocytes

FEBS Open Bio, EarlyView.
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley   +1 more source

Prevalence of liver disease and liver transplantation in pediatric ZZ alpha-1 antitrypsin deficiency: a systematic review and meta-analysis

Background Pediatric Pi*ZZ alpha-1 antitrypsin deficiency (A1ATD) can cause hepatocyte A1AT polymer retention and progressive liver injury, but estimates of childhood liver morbidity vary across studies and remain poorly defined.
Molokhia, Mariam, Georgantaki, Dimitra, Sakai, Manako, Rashid, S Tamir, Awsaf, Muhammad, Hadžić, Nedim, Syanda, Adam M, Thompson, Richard   +7 more
core   +1 more source

Therapeutic modulation of liver ischaemia reperfusion injury [PDF]

, 2011
Liver Ischaemia Reperfusion Injury (IRI) leads to production of reactive oxygen species and cytokines, which affects hepatocellular function following liver resection and transplantation.
Sheth, H.
core