Metabolic investigations prevent liver transplantation in two young children with citrullinemia type I [PDF]
, 2010 Acute liver failure may be caused by a variety of disorders including inborn errors of metabolism. In those cases, rapid metabolic investigations and adequate treatment may avoid the need for liver transplantation.
A Dhawan +23 more
core +11 more sources
Predicting outcome on admission and post-admission for acetaminophen-induced acute liver failure using classification and regression tree models. [PDF]
PLoS ONE, 2015 Assessing prognosis for acetaminophen-induced acute liver failure (APAP-ALF) patients often presents significant challenges. King's College (KCC) has been validated on hospital admission, but little has been published on later phases of illness. We aimed
Jaime Lynn Speiser +3 more
doaj +1 more source
Analysis of serum inflammatory mediators identifies unique dynamic networks associated with death and spontaneous survival in pediatric acute liver failure. [PDF]
PLoS ONE, 2013 Tools to predict death or spontaneous survival are necessary to inform liver transplantation (LTx) decisions in pediatric acute liver failure (PALF), but such tools are not available.
Nabil Azhar +6 more
doaj +1 more source
Detection of Ophthalmic Acid in Serum from Acetaminophen-Induced Acute Liver Failure Patients Is More Frequent in Non-Survivors. [PDF]
PLoS ONE, 2015 Acetaminophen (APAP) hepatotoxicity is related to the formation of N-acetyl-p-benzoquinone imine (NAPQI), which is detoxified through conjugation with reduced glutathione (GSH).
Gurnit Kaur +6 more
doaj +1 more source
EASL Clinical Practice Guidelines on acute-on-chronic liver failure.
Journal of Hepatology, 2023 Acute-on-chronic liver failure (ACLF) which has been recently described (2013), is a severe form of acutely decompensated cirrhosis characterized by the existence of organ system failure(s) and high risk of short-term death.
R. Moreau +11 more
semanticscholar +1 more source
Postgraduate Medical Journal, 1997 Abstract Acute liver failure is a complex multisystemic illness that evolves quickly after a catastrophic insult to the liver leading to the development of encephalopathy. The underlying aetiology and the pace of progression strongly influence the clinical course.
openaire +5 more sources
Future directions in acute liver failure
Hepatology, 2023 Acute liver failure (ALF) describes a clinical syndrome of rapid hepatocyte injury leading to liver failure manifested by coagulopathy and encephalopathy in the absence of pre-existing cirrhosis.
R. Stravitz +7 more
semanticscholar +1 more source
Acute-on-chronic liver failure: Terminology, mechanisms and management
Clinical and Molecular Hepatology, 2023 Acute-on-chronic liver failure is an acute deterioration of liver function manifesting as jaundice and coagulopathy with the development of ascites, with a high probability of extrahepatic organ involvement and high 28-day mortality.
V. Br, S. Sarin
semanticscholar +1 more source
Acute-on-Chronic Liver Failure Clinical Guidelines
American Journal of Gastroenterology, 2022 In patients with cirrhosis and chronic liver disease, acute-on-chronic liver failure is emerging as a major cause of mortality. These guidelines indicate the preferred approach to the management of patients with acute-on-chronic liver failure and ...
J. Bajaj +6 more
semanticscholar +1 more source
Clinical Medicine, 2015 Acute liver failure is a rare but potentially fatal disease. Adult definition of fulminant hepatic failure, which includes the development of hepatic necrosis and encephalopathy within 8 weeks of onset of liver disease does not apply to acute liver failure in children particularly if secondary to autoimmune or metabolic liver disease.
Laura, Blackmore, William, Bernal
openaire +4 more sources