Results 41 to 50 of about 626,132 (255)

Molecular pattern of lncRNAs in hepatocellular carcinoma

Journal of Experimental & Clinical Cancer Research, 2019
Hepatocellular carcinoma (HCC) is one of the most notable lethal malignancies worldwide. However, the molecular mechanisms involved in the initiation and progression of this disease remain poorly understood.
Haoming Mai, Bin Zhou, Li Liu, Fu Yang, Carly Conran, Yuan Ji, Jinlin Hou, Deke Jiang   +7 more
doaj   +1 more source

Upacicalcet: A Novel Intravenous Calcimimetic Agent for Patients Undergoing Hemodialysis With Secondary Hyperparathyroidism

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Secondary hyperparathyroidism (SHPT) is a common complication in patients receiving maintenance dialysis, driven by calcium and phosphate metabolism disturbances. Calcimimetics are central to the management of SHPT by enhancing calcium‐sensing receptor sensitivity and reducing parathyroid hormone secretion.
Fumihiko Koiwa, Daisuke Honda, Seigo Akari, Tadao Akizawa   +3 more
wiley   +1 more source

Acute-on-chronic liver failure: Definitions, pathophysiology and principles of treatmentKey points

JHEP Reports, 2021
Summary: The term acute-on-chronic liver failure (ACLF) defines an abrupt and life-threatening worsening of clinical conditions in patients with cirrhosis or chronic liver disease.
Giacomo Zaccherini, Emmanuel Weiss, Richard Moreau   +2 more
doaj   +1 more source

Adjunctive Therapeutic Plasma Exchange in Refractory Adult‐Onset Still's Disease Complicated by Secondary Macrophage Activation Syndrome: A Single‐Center Experience

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction Adult‐onset Still's disease (AOSD) complicated by macrophage activation syndrome (MAS) carries substantial mortality. The role of therapeutic plasma exchange (TPE) remains uncertain. Methods We retrospectively analyzed patients with AOSD‐MAS treated with TPE at a single‐center.
Masataka Ueda, Tomohiro Saito, Masahide Mizobuchi, Tomoki Shimomura, Saki Kawamori, Mitsuru Kawanishi, Natsuko Hattori, Jo Sugiyama, Satoshi Tsubata, Hanami Horiguchi, Kazuki Abe, Nao Iida, Yuki Kajio, Nao Oguro, Ryo Yanai, Hirokazu Honda   +15 more
wiley   +1 more source

Exosomes derived from 3D-cultured hUCMSCs exhibit superior hepatoprotection against ALF

iScience
Summary: Most recently, exosomes (Exos) derived from 3D-cultured cells exhibit great advantages over 2D-Exos. Nevertheless, it remains to be explored whether 3D (tissue engineering liver) exosomes are superior to 2D-Exos in protecting mice from acute ...
Huixin Tang, Wang Lu, Qi Yang, Yizhi Zhang, Xiaoxuan Liu, Shanshan Li, Manman Xu, Zhongping Duan, Li Bai, Yu Chen   +9 more
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Study on the Efficacy and Safety of Kuhuang Injection and Kuhuang Granules in the Sequential Treatment of Drug-induced Liver Injury: a Non-inferiority Randomized Controlled Trial [PDF]

Zhongguo quanke yixue
Background Drug-induced liver injury is the third major liver disease, following viral hepatitis and fatty liver disease. Timely diagnosis and effective treatment are crucial in halting disease progression and improving cure rates.
ZHANG Jiateng, KONG Ming, CHEN Yu, DUAN Zhongping
doaj   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Impact of Hepatic Encephalopathy on Clinical Characteristics and Adverse Outcomes in Prospective and Multicenter Cohorts of Patients With Acute-on-Chronic Liver Diseases

Frontiers in Medicine, 2021
Importance: Hepatic encephalopathy is a severe complication, and its contribution to clinical adverse outcomes in patients with acute-on-chronic liver diseases from the East is unclear.Objective: We aimed to investigate the impact of hepatic ...
Liyuan Long, Hai Li, Hai Li, Hai Li, Guohong Deng, Guohong Deng, Xianbo Wang, Xianbo Wang, Sihong Lu, Beiling Li, Zhongji Meng, Zhongji Meng, Yanhang Gao, Yanhang Gao, Zhiping Qian, Zhiping Qian, Feng Liu, Feng Liu, Feng Liu, Xiaobo Lu, Xiaobo Lu, Haotang Ren, Jia Shang, Hai Li, Shaoyang Wang, Yubao Zheng, Yubao Zheng, Huadong Yan, Huadong Yan, Shan Yin, Shan Yin, Wenting Tan, Qun Zhang, Xin Zheng, Xin Zheng, Jinjun Chen, Jinjun Chen, Sen Luo, Jinming Zhao, Wei Yuan, Tao Li, Rongjiong Zheng, Junping Liu, Xiaoxiao Liu, Wenyi Gu, Wenyi Gu, Sumeng Li, Xue Mei, Ruochan Chen, Yan Huang, Yan Huang   +50 more
doaj   +1 more source