Results 151 to 160 of about 509,312 (356)

Human umbilical cord mesenchymal stem cells enhance liver regeneration and decrease collagen content in fibrosis mice after partial hepatectomy by activating Wnt/β-catenin signaling

Acta Biochimica et Biophysica Sinica
Liver fibrosis is a critical stage in the progression of various chronic liver diseases to cirrhosis and liver cancer. Early inhibition of liver fibrosis is crucial for the treatment of liver disease.
Li Xuewei, Feng Jinghui, Cheng Haiqin, Jin Ning, Jin Shanshan, Liu Zhizhen, Xu Jun, Xie Jun   +7 more
doaj   +1 more source

Progression of liver fibrosis is associated with non‐liver‐related mortality in patients with nonalcoholic fatty liver disease [PDF]

, 2017
Toshifumi Tada, Takashi Kumada, Hidenori Toyoda, Kazuyuki Mizuno, Yasuhiro Sone, Tomoyuki Akita, Junko Tanaka   +6 more
openalex   +1 more source

An In Situ Embedded B‐MOF Sponge With Shape‐Memory for All‐in‐One Diabetic Wound Therapy

Advanced Healthcare Materials, EarlyView.
A smart shape‐memory sponge dressing (P1A3@B‐MOF) is developed for accelerated diabetic wound healing. It achieves pH‐responsive corelease of Zn2+ and salvianolic acid B, synergistically providing antibacterial action, repolarizing macrophages to the M2 phenotype, and promoting angiogenesis.
Hai Zhou, Chaoyang Huang, Yanqi Chen, Tingzi Zhao, Fengyi Zhu, Gong Jun, Jinrong Zhang, Yingsong Pan, Qiulan Wen, Lei Yang, Huihui Zhang, Lianglong Chen   +11 more
wiley   +1 more source

Nanogene editing drug delivery systems in the treatment of liver fibrosis

Frontiers in Medicine
Liver fibrosis is a group of diseases that seriously affect the health of the world’s population. Despite significant progress in understanding the mechanisms of liver fibrogenesis, the technologies and drugs used to treat liver fibrosis have limited ...
Qun Wang, Siyu Jia, Zihan Wang, Hui Chen, Xinyi Jiang, Yan Li, Peng Ji, Peng Ji   +7 more
doaj   +1 more source

Secondary bile acids improve risk prediction for non‐invasive identification of mild liver fibrosis in nonalcoholic fatty liver disease [PDF]

, 2023
A‐Na Liu, Cuifang Xu, Ya‐Ru Liu, Dan‐Qin Sun, Ling Jiang, Liang‐Jie Tang, Pei‐Wu Zhu, Sui‐Dan Chen, Wen‐Yue Liu, Xiaodong Wang, Giovanni Targher, Christopher D. Byrne, Vincent Wai‐Sun Wong, Junfen Fu, Mingming Su, Rohit Loomba, Ming‐Hua Zheng, Yan Ni   +17 more
openalex   +1 more source

LDI, A Lipid Droplet Inhibitor, Disrupts Lipid Accumulation and Modulates Hepatic Lipid Profiles in Fatty Liver

Advanced Materials, EarlyView.
The lipid droplet inhibitor (LDI), templated with large‐pore mesoporous silica and functionalized with PKCα C1A and lipase, targets lipid degradation in fatty liver. The LDI maintains stable association with lipid droplets, thereby suppressing their formation and expansion.
Seunghee Kim, Yeojin Kim, Sanjita Paudel, In Young Kang, Suyeon Kim, Jeesoo Kim, Sunmi Park, Seung‐Hoi Koo, Hyun Sung Kim, Dae Won Jun, Jinyoung Park, Hyunbeom Lee, Joonseok Lee   +12 more
wiley   +1 more source

Salmonella typhimurium exacerbates injuries but resolves fibrosis in liver and spleen during Schistosoma mansoni infection

, 2023
Ho Yin Pekkle Lam, Wen-Jui Wu, Ting-Ruei Liang, Hui-Chun Li, Kai‐Chih Chang, Shih-Yi Peng   +5 more
openalex   +1 more source

The Space Within: How Architected Voids Promote Tissue Formation

Advanced Materials, EarlyView.
This review explores the role of void spaces in tissue engineering scaffolds and examines four key methods for introducing porosity into hydrogels at different scales. It discusses sacrificial templating, microgels, phase separation, and 3D printing, highlighting principles, advantages, and limitations. It also addresses emerging strategies integrating
Anna Puiggalí‐Jou, Isabel B. Hui, Carla Fernandez‐Rico, Marcy Zenobi‐Wong   +3 more
wiley   +1 more source

Bacteria‐Responsive Nanostructured Drug Delivery Systems for Targeted Antimicrobial Therapy

Advanced Materials, EarlyView.
Bacteria‐responsive nanocarriers are designed to release antimicrobials only in the presence of infection‐specific cues. This selective activation ensures drug release precisely at the site of infection, avoiding premature or indiscriminate release, and enhancing efficacy.
Guillermo Landa, Gracia Mendoza, Silvia Irusta, Manuel Arruebo   +3 more
wiley   +1 more source

3D Bioprinted Human Synovium‐Cartilage Models Mimic Rheumatoid Arthritis Microenvironment and Recapitulate In Vivo Therapeutic Responses

Advanced Materials, EarlyView.
This study presents human in vitro rheumatoid arthritis models using chondrocytes recellularized type II collagen scaffold and 3D‐bioprinted Gelatin‐Matrigel hydrogels with fibroblast‐like synoviocytes, pro‐inflammatory macrophages, and protective barrier macrophages, closely recapitulating key rheumatoid arthritis pathological features.
Huiqun Zhou, Zhen Zhang, Yulei Mu, Liang Ma, Xu Hu, Bangheng Liu, Dong‐An Wang   +6 more
wiley   +1 more source