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Pathogenesis of Liver Fibrosis
Annual Review of Pathology: Mechanisms of Disease, 2011Liver fibrosis is a major cause of morbidity and mortality worldwide due to chronic viral hepatitis and, more recently, from fatty liver disease associated with obesity. Hepatic stellate cell activation represents a critical event in fibrosis because these cells become the primary source of extracellular matrix in liver upon injury. Use of cell-culture
Virginia, Hernandez-Gea +1 more
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Seminars in Liver Disease, 2009
Alcoholic liver disease involves significant crosstalk among intracellular signaling events in the liver. Overall, inflammatory and innate immune responses in Kupffer cells due to elevated gut-derived plasma endotoxin levels, increased reactive oxygen species-induced damage, and profibrogenic factors such as acetaldehyde or lipid peroxidation products ...
Francisco Javier, Cubero +2 more
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Alcoholic liver disease involves significant crosstalk among intracellular signaling events in the liver. Overall, inflammatory and innate immune responses in Kupffer cells due to elevated gut-derived plasma endotoxin levels, increased reactive oxygen species-induced damage, and profibrogenic factors such as acetaldehyde or lipid peroxidation products ...
Francisco Javier, Cubero +2 more
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Cystic fibrosis liver sialyltransferase
Clinical Genetics, 1978The activity of sialyltransferase with regard to the glycoprotein substrates asialofetuin and asialo‐ovine submaxillary mucin was determined in normal, pathological control, and cystic fibrosis liver homogenates. Cystic fibrosis and pathological livers have about 40% of the average normal specific activity for sialyltransferase.Several properties of ...
J A, Alhadeff, G, Cimino
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Clinica Chimica Acta, 2006
Liver fibrosis represents a significant health problem worldwide of which no acceptable therapy exists. The most characteristic feature of liver fibrosis is excess deposition of type I collagen. A great deal of research has been performed to understand the molecular mechanisms responsible for the development of liver fibrosis.
Shigeki, Tsukada +2 more
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Liver fibrosis represents a significant health problem worldwide of which no acceptable therapy exists. The most characteristic feature of liver fibrosis is excess deposition of type I collagen. A great deal of research has been performed to understand the molecular mechanisms responsible for the development of liver fibrosis.
Shigeki, Tsukada +2 more
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Liver Fibrosis in Alcoholic Liver Disease
Seminars in Liver Disease, 2015Excessive alcohol consumption causes a wide spectrum of liver disease, ranging from simple steatosis to severe forms of liver injury such as steatohepatitis, liver fibrosis, cirrhosis, and liver cancer. Moreover, alcohol consumption also accelerates liver fibrosis in patients with other types of liver diseases such as viral hepatitis and nonalcoholic ...
Ramon, Bataller, Bin, Gao
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Pathophysiology of Liver Fibrosis
Digestive Diseases, 2015Progressive accumulation of fibrillar extracellular matrix (ECM) in the liver is the consequence of reiterated liver tissue damage due to infective (mostly hepatitis B and C viruses), toxic/drug-induced, metabolic and autoimmune causes, and the relative chronic activation of the wound-healing reaction. The process may result in clinically evident liver
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Journal of Gastroenterology and Hepatology, 2011
AbstractFibrosis prediction is an essential part of the assessment and management of patients with chronic liver disease. Blood‐based biomarkers offer a number of advantages over the traditional standard of fibrosis assessment of liver biopsy, including safety, cost‐savings and wide spread accessibility.
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AbstractFibrosis prediction is an essential part of the assessment and management of patients with chronic liver disease. Blood‐based biomarkers offer a number of advantages over the traditional standard of fibrosis assessment of liver biopsy, including safety, cost‐savings and wide spread accessibility.
openaire +2 more sources