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Are liver function tests required for patients taking isoniazid for latent TB? [PDF]

open access: yes, 2004
Routine liver function test monitoring is not required for all patients on isoniazid therapy for latent tuberculosis (TB) infection (strength of recommendation: B, based on case series). No clinical trials have studied the potential risks and benefits of
Brown, Maureen O'Reilly, Howard, Ellen
core  

MET variants with activating N‐lobe mutations identified in hereditary papillary renal cell carcinomas still require ligand stimulation

open access: yesMolecular Oncology, EarlyView.
MET variants in the N‐lobe of the kinase domain, found in hereditary papillary renal cell carcinoma, require ligand stimulation to promote cell transformation, in contrast to other RTK variants. This suggests that HGF expression in the microenvironment is important for tumor growth in such patients. Their sensitivity to MET inhibitors opens the way for
Célia Guérin   +14 more
wiley   +1 more source

Role of liver function tests among pregnant women with respect to feto-maternal outcome in third trimester: an analytical cross-sectional study [PDF]

open access: yes
Background: Liver disease occurs in approximately 3% of pregnant women so it has adverse effect on feto-maternal outcome. Diseases specifically related to pregnancy are intra-hepatic cholestasis of pregnancy, acute fatty liver of pregnancy, abnormal ...
Lal, Pavika   +3 more
core   +2 more sources

Etoposide‐induced cancer cell death: roles of mitochondrial VDAC1 and calpain, and resistance mechanisms

open access: yesMolecular Oncology, EarlyView.
The complex mode of action of the topoisomerase II inhibitor etoposide in triggering apoptosis involves several mechanisms: overexpression of the mitochondrial protein VDAC1, leading to its oligomerization and formation of a large channel that mediates the release of pro‐apoptotic protein; and overexpression of the apoptosis regulators p53, Bax, and ...
Aditya Karunanithi Nivedita   +1 more
wiley   +1 more source

Liver Function Tests During the Perinatal Period

open access: yesNigerian Journal of Paediatrics
Summary: Serum iso-citrate dehydrogenase (ICD), aspartate transaminase (AST), alkaline phosphatase (ALP) gamma-glutamyli deter transferase (GGT), total bilirubin, total protein and albumin were deter mined and compared in 68 paired maternal and ...
Onwuameze IC..
doaj  

LABRAD : Vol 36, Issue 1 - January 2011 [PDF]

open access: yes, 2011
Routine and Special Liver Function Tests Management of Coagulopathy Associated with Liver Disease Significance of Clinical and Laboratory Scoring System in Diagnosis of Disseminated Intravascular Coagulation in Chronic Liver Disease Laboratory Diagnosis ...
Aga Khan University Hospital, Karachi
core   +1 more source

Respiratory complex I‐mediated NAD+ regeneration regulates cancer cell proliferation through the transcriptional and translational control of p21Cip1 expression by SIRT3 and SIRT7

open access: yesMolecular Oncology, EarlyView.
NAD+ regeneration by mitochondrial complex I NADH dehydrogenase is important for cancer cell proliferation. Specifically, NAD+ is necessary for the activities of NAD+‐dependent deacetylases SIRT3 and SIRT7, which suppress the expression of p21Cip1 cyclin‐dependent kinase inhibitor, an antiproliferative molecule, at the translational and transcriptional
Masato Higurashi   +5 more
wiley   +1 more source

Peripheral blood proteome biomarkers distinguish immunosuppressive features of cancer progression

open access: yesMolecular Oncology, EarlyView.
Immune status significantly influences cancer progression. This study used plasma proteomics to analyze benign 67NR and malignant 4T1 breast tumor models at early and late tumor stages. Immune‐related proteins–osteopontin (Spp1), lactotransferrin (Ltf), calreticulin (Calr) and peroxiredoxin 2 (Prdx2)–were associated with systemic myeloid‐derived ...
Yeon Ji Park   +6 more
wiley   +1 more source

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