Results 1 to 10 of about 4,185,241 (381)

Study on ferritin and liver injury in pediatric hemophagocytic lymphohistiocytosis associated with infection [PDF]

Scientific Reports
Summarize and analyze the clinical characteristics of children with infection-associated hemophagocytic lymphohistiocytosis (IAHLH) complicated by liver injury, and investigate the correlation between ferritin (FERR) and liver injury indicators.
Gailing Hao, Quanheng Li, Nan Zhang, Weili Guo, Xiao Wang, Wenjin Geng   +5 more
doaj   +2 more sources

Deficiency of NOX1 or NOX4 Prevents Liver Inflammation and Fibrosis in Mice through Inhibition of Hepatic Stellate Cell Activation. [PDF]

, 2015
Reactive oxygen species (ROS) produced by nicotinamide adenine dinucleotide phosphate oxidase (NOX) play a key role in liver injury and fibrosis. Previous studies demonstrated that GKT137831, a dual NOX1/4 inhibitor, attenuated liver fibrosis in mice as ...
Brenner, David A, Kisseleva, Tatiana, Lan, Tian   +2 more
core   +15 more sources

ACG Clinical Guideline: Diagnosis and Management of Idiosyncratic Drug-Induced Liver Injury.

American Journal of Gastroenterology, 2021
Idiosyncratic drug-induced liver injury (DILI) is common in gastroenterology and hepatology practices, and it can have multiple presentations, ranging from asymptomatic elevations in liver biochemistries to hepatocellular or cholestatic jaundice, liver ...
M. F. Naga P. Chalasani, MD Haripriya Maddur, M. M. F. Mark W. Russo, M. M. F. G. M. Robert J. Wong, M. F. K. Rajender Reddy   +4 more
semanticscholar   +1 more source

Exposure to per- and Polyfluoroalkyl Substances and Markers of Liver Injury: A Systematic Review and Meta-Analysis

Environmental Health Perspectives, 2022
Background: Experimental evidence indicates that exposure to certain pollutants is associated with liver damage. Per- and polyfluoroalkyl substances (PFAS) are persistent synthetic chemicals widely used in industry and consumer products and bioaccumulate
E. Costello, Sarah Rock, N. Stratakis, S. Eckel, D. Walker, D. Valvi, Dora Cserbik, Todd Jenkins, S. Xanthakos, Rohit Kohli, Stephanie Sisley, V. Vasiliou, M. L. La Merrill, Hugo R. Rosen, D. Conti, R. McConnell, L. Chatzi   +16 more
semanticscholar   +1 more source

Endoplasmic reticulum stress-mediated cell death in liver injury

Cell Death and Disease, 2022
The endoplasmic reticulum is an important intracellular organelle that plays an important role in maintaining cellular homeostasis. Endoplasmic reticulum stress (ERS) and unfolded protein response (UPR) are induced when the body is exposed to adverse ...
Jian Zhang, Jiafu Guo, Nannan Yang, Yan Huang, Tingting Hu, Chaolong Rao   +5 more
semanticscholar   +1 more source

Akkermansia muciniphila Ameliorates Acetaminophen-Induced Liver Injury by Regulating Gut Microbial Composition and Metabolism

Microbiology spectrum, 2022
Our work revealed that A. muciniphila attenuated APAP-induced liver injury by alleviating oxidative stress and inflammation in the liver, and its hepatoprotective effect was accompanied by activation of the PI3K/Akt pathway and mediated by regulation of ...
Jiafeng Xia, L. Lv, Boqiang Liu, Sheng Wang, Sitong Zhang, Zhengjie Wu, Liya Yang, Xiaoyuan Bian, Qiangqiang Wang, Kaicen Wang, Aoxiang Zhuge, Shengjie Li, Ren Yan, Huiyong Jiang, Kaijin Xu, Lanjuan Li   +15 more
semanticscholar   +1 more source

S1PR1 induces metabolic reprogramming of ceramide in vascular endothelial cells, affecting hepatocellular carcinoma angiogenesis and progression

Cell Death and Disease, 2022
Angiogenesis is a fundamental process underlying the occurrence, growth and metastasis of hepatocellular carcinoma (HCC), a prevalent tumour type with an extremely poor prognosis due to abundant vasculature.
Xuehong Wang, Zhidong Qiu, Wei Dong, Zebin Yang, Junnan Wang, Hailiang Xu, Tian Sun, Zhaoquan Huang, Junfei Jin   +8 more
doaj   +1 more source

Acid ceramidase targeting pyruvate kinase affected trypsinogen activation in acute pancreatitis

Molecular Medicine, 2022
Background Acute pancreatitis is the sudden inflammation of the pancreas. Severe cases of acute pancreatitis are potentially fatal and have no specific treatment available. Premature trypsinogen activation could initiate acute pancreatitis.
Juan Xiao, Wenying Zeng, Pengcheng Zhang, Yuan Zhou, Qiangqiang Fang   +4 more
doaj   +1 more source

Pulmonary interleukin 1 beta/serum amyloid A3 axis promotes lung metastasis of hepatocellular carcinoma by facilitating the pre-metastatic niche formation

Journal of Experimental & Clinical Cancer Research, 2023
Background Increasing evidence suggests a vital role of the pre-metastatic niche in the formation of distant metastasis of many cancers. However, how the pre-metastatic niche is formed and promotes pulmonary metastasis of hepatocellular carcinoma (HCC ...
Chong Zhang, Qing Li, Qi Xu, Wei Dong, Chunmei Li, Bin Deng, Jiao Gong, Li-Zhen Zhang, Junfei Jin   +8 more
doaj   +1 more source

Crosstalk between Oxidative Stress and Inflammatory Liver Injury in the Pathogenesis of Alcoholic Liver Disease

International Journal of Molecular Sciences, 2022
Alcoholic liver disease (ALD) is characterized by the injury, inflammation, and scarring in the liver owing to excessive alcohol consumption. Currently, ALD is a leading cause for liver transplantation.
Y. Yang, Y. Cho, Seonghwan Hwang
semanticscholar   +1 more source