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Drug-induced liver injury [PDF]
Nature Reviews Disease Primers, 2019 Drug-induced liver injury (DILI) is an adverse reaction to drugs or other xenobiotics that occurs either as a predictable event when an individual is exposed to toxic doses of some compounds or as an unpredictable event with many drugs in common use. Drugs can be harmful to the liver in susceptible individuals owing to genetic and environmental risk ...
Neil Kaplowitz +13 more
semanticscholar +7 more sources
Drug-induced liver injury [PDF]
Yeungnam University Journal of Medicine, 2020 Drug-induced liver injury (DILI), including herbal and dietary supplement hepatotoxicity, is often passed lightly; however, it can lead to the requirement of a liver transplant or may even cause death because of liver failure. Recently, the American College of Gastroenterology, Chinese Society of Hepatology and European Association for the Study of the
Lily Dara, N. Kaplowitz
openaire +5 more sources
Hepatic Macrophages in Liver Injury
Frontiers in Immunology, 2020 Ample evidence suggests that hepatic macrophages play key roles in the injury and repair mechanisms during liver disease progression. There are two major populations of hepatic macrophages: the liver resident Kupffer cells and the monocyte-derived macrophages, which rapidly infiltrate the liver during injury.
Cynthia Ju, Zhao Shan
openaire +4 more sources
Environmental Health Perspectives, 2022 Background: Experimental evidence indicates that exposure to certain pollutants is associated with liver damage. Per- and polyfluoroalkyl substances (PFAS) are persistent synthetic chemicals widely used in industry and consumer products and bioaccumulate
E. Costello +16 more
semanticscholar +1 more source
ACG Clinical Guideline: Diagnosis and Management of Idiosyncratic Drug-Induced Liver Injury.
American Journal of Gastroenterology, 2021 Idiosyncratic drug-induced liver injury (DILI) is common in gastroenterology and hepatology practices, and it can have multiple presentations, ranging from asymptomatic elevations in liver biochemistries to hepatocellular or cholestatic jaundice, liver ...
M. F. Naga P. Chalasani +4 more
semanticscholar +1 more source
Microbiology spectrum, 2022 Our work revealed that A. muciniphila attenuated APAP-induced liver injury by alleviating oxidative stress and inflammation in the liver, and its hepatoprotective effect was accompanied by activation of the PI3K/Akt pathway and mediated by regulation of ...
Jiafeng Xia +15 more
semanticscholar +1 more source
Cell Death and Disease, 2022 Angiogenesis is a fundamental process underlying the occurrence, growth and metastasis of hepatocellular carcinoma (HCC), a prevalent tumour type with an extremely poor prognosis due to abundant vasculature.
Xuehong Wang +8 more
doaj +1 more source
Acid ceramidase targeting pyruvate kinase affected trypsinogen activation in acute pancreatitis
Molecular Medicine, 2022 Background Acute pancreatitis is the sudden inflammation of the pancreas. Severe cases of acute pancreatitis are potentially fatal and have no specific treatment available. Premature trypsinogen activation could initiate acute pancreatitis.
Juan Xiao +4 more
doaj +1 more source
Journal of Experimental & Clinical Cancer Research, 2023 Background Increasing evidence suggests a vital role of the pre-metastatic niche in the formation of distant metastasis of many cancers. However, how the pre-metastatic niche is formed and promotes pulmonary metastasis of hepatocellular carcinoma (HCC ...
Chong Zhang +8 more
doaj +1 more source