Results 41 to 50 of about 27,503 (167)
In Vitro Metabolism and In Vivo Pharmacokinetics Profiles of Hydroxy-α-Sanshool
ToxicsHydroxy-α-sanshool (HAS) is the predominant active compound in Zanthoxylum bungeanum Maxim (ZBM). Our present work was aimed to explore the in vitro metabolism characteristics, and in vivo pharmacokinetic (PK) profile of HAS.
Jie Meng +4 more
doaj +1 more source
Journal of Lipid Research, 1977 The NADH-dependent stearoyl CoA desaturase of hepatic microsomes (EC 1.14.99.5) is an enzyme system consisting of cytochrome b5 reductase (EC 1.6.2.2), cytochrome b5, and the terminal desaturase. We have developed a simple method for routine assay of the
V C Joshi, A C Wilson, S J Wakil
doaj +1 more source
Biosynthesis of presqualene pyrophosphate by liver microsomes
Journal of Lipid Research, 1970 Microsomes from rat liver have been shown to synthesize a squalene precursor from farnesyl pyrophosphate. This intermediate is identical with presqualene pyrophosphate, a 30-carbon cyclopropane containing pyrophosphate ester that had previously been ...
H.C. RILLING
doaj +1 more source
Activation of HMG-CoA reductase by microsomal phosphatase
Journal of Lipid Research, 1983 HMG-CoA reductase activity can be modulated by a reversible phosphorylation-dephosphorylation with the phosphorylated form of the enzyme being inactive and the dephosphorylated form, active. Phosphatases from diverse sources, including cytosol, have been
K R Feingold +4 more
doaj +1 more source
Sidedness of ceramide-phosphoethanolamine synthesis on rat liver and brain microsomal membranes.
Journal of Lipid Research, 1987 Phosphatidylethanolamine:ceramide-ethanolamine-phosphotransferase catalyzes the synthesis of ceramide-phosphoethanolamine, a sphingomyelin analogue. Its localization was studied in rat liver and brain microsomes.
M Malgat, A Maurice, J Baraud
doaj +1 more source
Journal of Lipid Research, 1998 In vitro techniques have been used to investigate the nature of microsomal cytochrome P450 involved in the metabolism of oleic acid, a physiological monounsaturated fatty acid. Like lauric acid, which is cur rently used as a model substrate of fatty acid
Fadi Adas +5 more
doaj +1 more source
Towards the Development of an In vivo Chemical Probe for Cyclin G Associated Kinase (GAK)
Molecules, 2019 SGC-GAK-1 (1) is a potent, selective, cell-active chemical probe for cyclin G-associated kinase (GAK). However, 1 was rapidly metabolized in mouse liver microsomes by cytochrome P450-mediated oxidation, displaying rapid clearance in liver microsomes and ...
Christopher R. M. Asquith +9 more
doaj +1 more source
Lipid composition and turnover of rough and smooth microsomal membranes in rat liver
Journal of Lipid Research, 1968 Subfractions of rat liver microsomes (rough, smooth I, and smooth II), isolated in a cation-containing sucrose gradient system, were analyzed. After removal of adsorbed and luminal protein, these subfractions had the same phospholipid/protein ratio ...
Hans Glaumann, Gustav Dallner
doaj +1 more source
Studies on acyl-coenzyme A: cholesterol acyltransferase activity in human liver microsomes.
Journal of Lipid Research, 1989 The aim of the present study was to characterize the acyl-coenzyme A: cholesterol acyltransferase (ACAT) activity in human liver microsomes. Liver biopsies were obtained from patients undergoing elective cholecystectomy under highly standardized ...
K Einarsson +5 more
doaj +1 more source
Sensors, 2009 In the present study, we characterized the kinetic parameters of 7-ethoxy-resorufin O-deethylation (EROD) and 7-methoxyresorufin O-demethylation (MROD) in hepatic microsomes from entire and castrated male pigs.
Vladimir Zlabek, Galia Zamaratskaia
doaj +1 more source