Results 31 to 40 of about 418,078 (213)

Exposure to Maternal Immune Activation Causes Congenital Unfolded Protein Response Defects and Increases the Susceptibility to Postnatal Inflammatory Stimulation in Offspring

Journal of Inflammation Research, 2021
Yo Shimizu,1 Tsuyoshi Tsukada,2 Hiromi Sakata-Haga,2 Daisuke Sakai,3 Hiroki Shoji,3 Yutaka Saikawa,1 Toshihisa Hatta2 1Department of Pediatrics, Kanazawa Medical University, Uchinada, Ishikawa, Japan; 2Department of Anatomy, Kanazawa Medical University ...
Shimizu Y, Tsukada T, Sakata-Haga H, Sakai D, Shoji H, Saikawa Y, Hatta T   +6 more
doaj  

A dual role of inflammation in acetaminophen-induced liver injury

Liver Research, 2023
In many affluent nations, acetaminophen (APAP) overdose is the leading cause of drug-induced acute liver failure. The process of APAP-induced liver injury (AILI) is intimately tied to inflammation, including hepatocyte necrosis-caused initiation of ...
Long Xu, Hua Wang
doaj   +1 more source

Response to combination therapy with interferon alfa-2a and ribavirin in chronic hepatitis C according to a TNF-alpha promoter polymorphism [PDF]

, 2003
Background. Tumor necrosis factor-alpha (TNF-alpha) is involved in the pathogenesis of chronic active hepatitis C. Polymorphisms in the promoter region of the TNF-alpha gene can alter the TNF-alpha expression and modify the host immune response.
Konig, A., Folwaczny, Christian, Schmidt, F., Simperl, C., Schaefer, M., Torok, P., Glas, J., Schiemann, Uwe, Martin, K.   +8 more
core   +1 more source

A special type of liver failure after partial hepatectomy: a case report

Frontiers in Oncology
Posthepatectomy liver failure (PHLF) is one of the most harmful complications after liver resection. Here, we report a case of a specific type of PHLF in a 60-year-old man with hepatocellular carcinoma.
Linxiao Gao, Bing Tu, Mingxiang Cheng, Menghao Wang   +3 more
doaj   +1 more source

Liver Immune Cells Release Type 1 Interferon Due to DNA Sensing and Amplify Liver Injury from Acetaminophen Overdose

Cells, 2018
Hepatocytes may rupture after a drug overdose, and their intracellular contents act as damage-associated molecular patterns (DAMPs) that lead to additional leukocyte infiltration, amplifying the original injury.
Alan Moreira de Araujo, Maísa Mota Antunes, Matheus Silvério Mattos, Ariane Barros Diniz, Débora Moreira Alvarenga, Brenda Naemi Nakagaki, Érika de Carvalho, Viviane Aparecida Souza Lacerda, Raquel Carvalho-Gontijo, Jorge Goulart, Kassiana Mafra, Maria Alice Freitas-Lopes, Hortência Maciel de Castro Oliveira, Camila Miranda Dutra, Bruna Araújo David, Aristóbolo Mendes Silva, Valerie Quesniaux, Bernhard Ryffel, Sergio Costa Oliveira, Glen N. Barber, Daniel Santos Mansur, Thiago Mattar Cunha, Rafael Machado Rezende, André Gustavo Oliveira, Gustavo Batista Menezes   +24 more
doaj   +1 more source

C-Jun N-terminal kinase 2 promotes liver injury via the mitochondrial permeability transition after hemorrhage and resuscitation

, 2012
Hemorrhagic shock leads to hepatic hypoperfusion and activation of mitogen-activated stress kinases (MAPK) like c-Jun N-terminal kinase (JNK) 1 and 2. Our aim was to determine whether mitochondrial dysfunction leading to hepatic necrosis and apoptosis ...
Zhong, Zhi, Lehnert, Mark, Marzi, Ingo, Maldonado, Eduardo N., Lemasters, John J., Czerny, Christoph, Theruvath, Tom Prakash   +6 more
core   +1 more source

Hepatocellular carcinoma: IVIM diffusion quantification for prediction of tumor necrosis compared to enhancement ratios

European Journal of Radiology Open, 2016
Purpose: To correlate intra voxel incoherent motion (IVIM) diffusion parameters of liver parenchyma and hepatocellular carcinoma (HCC) with degree of liver/tumor enhancement and necrosis; and to assess the diagnostic performance of diffusion parameters ...
Suguru Kakite, Hadrien A. Dyvorne, Karen M. Lee, Guido H. Jajamovich, Ashley Knight-Greenfield, Bachir Taouli   +5 more
doaj   +1 more source

Mesenchymal stem cells protect against acetaminophen hepatotoxicity by secreting regenerative cytokine hepatocyte growth factor

Stem Cell Research & Therapy, 2022
Background Acetaminophen (APAP) overdose is a major cause of the morbidity of acute liver failure. The current clinically approved treatment for APAP poisoning, N-acetylcysteine (NAC), has a limited therapeutic window, and prolonged treatment with NAC ...
Ping Wang, Yan Cui, Jing Wang, Donghua Liu, Yue Tian, Kai Liu, Xue Wang, Lin Liu, Yu He, Yufeng Pei, Li Li, Liying Sun, Zhijun Zhu, Dehua Chang, Jidong Jia, Hong You   +15 more
doaj   +1 more source

Genes related to apoptosis predict necrosis of the liver as a phenotype observed in rats exposed to a compendium of hepatotoxicants

BMC Genomics, 2008
Background Some of the biochemical events that lead to necrosis of the liver are well-known. However, the pathogenesis of necrosis of the liver from exposure to hepatotoxicants is a complex biological response to the injury.
Zeng Zhao-Bang, Heinloth Alexandra N, Huang Lingkang, Paules Richard S, Bushel Pierre R   +4 more
doaj   +1 more source

Molecular cloning, expression analysis and assignment of the porcine tumor necrosis factor superfamily member 10 gene (TNFSF10) to SSC13q34 -> q36 by fluorescence in situ hybridization and radiation hybrid mapping [PDF]

, 2005
We have cloned the complete coding region of the porcine TNFSF10 gene. The porcine TNFSF10 cDNA has an ORF of 870 nucleotides and shares 85 % identity with human TNFSF10, and 75% and 72% identity with rat and mouse Tnfsf10 coding sequences, respectively.
Kemter, E., Kemter, E, Leeb, T., Kuiper, H., Klose, R., Boelhauve, M., Kuiper, H, Philipp, U., Philipp, U, Wolf, E, Distl, O., Wolf, E., Klose, R, Leeb, Tosso, Distl, O, Boelhauve, M   +15 more
core   +1 more source