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SLC1A5-dependent glutamine uptake in hepatocytes promotes liver regeneration. [PDF]

open access: yesHepatol Commun
Duan Y   +16 more
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Liver regeneration and liver metastasis

Seminars in Cancer Biology, 2021
Surgical resection for primary and secondary hepatic neoplasms provides the best chance of cure. Advanced surgical techniques such as portal vein embolisation, two-staged hepatectomy and associated liver partition and portal vein ligation for staged-hepatectomy (ALPPS) have facilitated hepatic resection in patients with previously unresectable, bi ...
Georgina E, Riddiough   +3 more
openaire   +2 more sources

Liver Regeneration

Science, 1997
Liver regeneration after the loss of hepatic tissue is a fundamental parameter of liver response to injury. Recognized as a phenomenon from mythological times, it is now defined as an orchestrated response induced by specific external stimuli and involving sequential changes in gene expression, growth factor production, and morphologic structure.
G K, Michalopoulos, M C, DeFrances
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Liver regeneration

Frontiers in Bioscience, 2002
Unlike other vital organs, the liver typically regenerates after injury. Indeed, the very factors that cause liver injury initiate a reparative process in the residual liver that includes the induction of cytoprotective mechanisms, deletion of mortally wounded cells, repair of less damaged survivors, liver cell proliferation to replace the cells that ...
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Liver regeneration

Journal of Hepatology, 2000
The liver can precisely regulate its growth and mass. Surgical resection of hepatic lobes or hepatocyte loss caused by viral or chemical injury triggers hepatocyte replication while enlarged liver mass is corrected by apoptosis. Hepatocytes have a great replicative capacity and are capable of repopulating the liver.
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Aging and liver regeneration

Trends in Endocrinology & Metabolism, 2009
The loss of regenerative capacity is the most dramatic age-associated alteration in the liver. Although this phenomenon was reported over 50 years ago, the molecular basis for the loss of regenerative capacity of aged livers has not been fully elucidated.
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