Results 1 to 10 of about 2,725,674 (324)

Hypothermic Machine Perfusion in Liver Transplantation - A Randomized Trial.

New England Journal of Medicine, 2021
BACKGROUND Transplantation of livers obtained from donors after circulatory death is associated with an increased risk of nonanastomotic biliary strictures.
R. van Rijn, I. Schurink, Y. de Vries, A. P. van den Berg, M. Cortés Cerisuelo, S. Darwish Murad, J. Erdmann, N. Gilbo, R. D. de Haas, N. Heaton, B. van Hoek, V. Huurman, I. Jochmans, O. B. van Leeuwen, V. D. de Meijer, D. Monbaliu, W. Polak, J. Slangen, R. Troisi, A. Vanlander, J. de Jonge, R. Porte   +21 more
semanticscholar   +1 more source

A Transformer-Based Deep Learning Approach for Fairly Predicting Post-Liver Transplant Risk Factors [PDF]

J Biomed Inform. 2024 Jan;149:104545, 2023
Liver transplantation is a life-saving procedure for patients with end-stage liver disease. There are two main challenges in liver transplant: finding the best matching patient for a donor and ensuring transplant equity among different subpopulations. The current MELD scoring system evaluates a patient's mortality risk if not receiving an organ within ...
arxiv   +1 more source

Cholangiocyte organoids can repair bile ducts after transplantation in the human liver

Science, 2021
Organoids regenerate human bile ducts Bile ducts carry bile from the liver and gall bladder to the small intestine, where it aids digestion. Cholangiocytes are epithelial cells that line bile ducts and modify bile as its transported through the biliary ...
F. Sampaziotis, D. Muraro, Olivia C. Tysoe, S. Sawiak, T. Beach, E. Godfrey, S. Upponi, T. Brevini, B. Wesley, J. Garcia-Bernardo, Krishnaa T. Mahbubani, Giovanni Canu, Richard L. Gieseck, N. L. Berntsen, Victoria L. Mulcahy, K. Crick, C. Fear, Sharayne Robinson, L. Swift, L. Gambardella, Johannes Bargehr, Daniel Ortmann, S. Brown, Anna Osnato, M. Murphy, G. Corbett, W. Gelson, G. Mells, Peter Humphreys, S. Davies, I. Amin, P. Gibbs, S. Sinha, S. Teichmann, A. Butler, T. See, E. Melum, C. Watson, K. Saeb‐Parsy, L. Vallier   +39 more
semanticscholar   +1 more source

Adjuvant Transarterial chemoembolization does not influence recurrence-free or overall survival in patients with combined hepatocellular carcinoma and Cholangiocarcinoma after curative resection: a propensity score matching analysis

BMC Cancer, 2020
Background The prognosis of patients with combined hepatocellular carcinoma and intrahepatic cholangiocarcinoma (CHC) is usually poor, and effective adjuvant therapy is missing making it important to investigate whether these patients may benefit from ...
Wei-Ren Liu, Meng-Xin Tian, Chen-Yang Tao, Zheng Tang, Yu-Fu Zhou, Shu-Shu Song, Xi-Fei Jiang, Han Wang, Pei-Yun Zhou, Wei-Feng Qu, Yuan Fang, Zhen-Bin Ding, Jian Zhou, Jia Fan, Ying-Hong Shi   +14 more
doaj   +1 more source

KRAS acting through ERK signaling stabilizes PD-L1 via inhibiting autophagy pathway in intrahepatic cholangiocarcinoma

Cancer Cell International, 2022
Background While the correlation between PD-L1 expression and KRAS mutation has been previously reported in other solid tumors such as non-small cell lung cancer (NSCLC), whether PD-L1 can be modulated by ERK signaling downstream of KRAS in intrahepatic ...
Zheng Gao, Jia-Feng Chen, Xiao-Gang Li, Ying-Hong Shi, Zheng Tang, Wei-Ren Liu, Xin Zhang, Ao Huang, Xuan-Ming Luo, Qiang Gao, Guo-Ming Shi, Ai-Wu Ke, Jian Zhou, Jia Fan, Xiu-Tao Fu, Zhen-Bin Ding   +15 more
doaj   +1 more source

The Efficacy and Safety of Hepatic Arterial Infusion Chemotherapy Based on FOLFIRI for Advanced Intrahepatic Cholangiocarcinoma as Second-Line and Successive Treatment: A Real-World Study

Canadian Journal of Gastroenterology and Hepatology, 2022
Objective. Intrahepatic cholangiocarcinoma (iCCA) is a primary liver malignancy with a poor prognosis and limited treatment. Cisplatin with gemcitabine is used as the standard first-line chemotherapy regimen; however, there is still no robust evidence ...
Peixin Huang, Xiaoyong Huang, Yingting Zhou, Guohuan Yang, Qiman Sun, Guoming Shi, Yi Chen   +6 more
doaj   +1 more source

Integrative analyses identify CD73 as a prognostic biomarker and immunotherapeutic target in intrahepatic cholangiocarcinoma

World Journal of Surgical Oncology, 2023
Background CD73 promotes progression in several malignancies and is considered as a novel immune checkpoint. However, the function of CD73 in intrahepatic cholangiocarcinoma (ICC) remains uncertain.
Bao-Ye Sun, Zhang-Fu Yang, Zhu-Tao Wang, Gao Liu, Cheng Zhou, Jian Zhou, Jia Fan, Wei Gan, Yong Yi, Shuang-Jian Qiu   +9 more
doaj   +1 more source

SQSTM1/p62 in intrahepatic cholangiocarcinoma promotes tumor progression via epithelial–mesenchymal transition and mitochondrial function maintenance

Cancer Medicine, 2023
Background SQSTM1/p62 is a selective autophagy receptor that regulates multiple signaling pathways participating in the initiation and progression of tumors.
Jiafeng Chen, Zheng Gao, Xiaogang Li, Yinghong Shi, Zheng Tang, Weiren Liu, Xin Zhang, Ao Huang, Xuanming Luo, Qiang Gao, Guangyu Ding, Kang Song, Jian Zhou, Jia Fan, Xiutao Fu, Zhenbin Ding   +15 more
doaj   +1 more source

The impact of tumor burden at the initial hepatectomy on the recurrence-to-death survival after repeat surgical resection/radiofrequency ablation: a retrospective study

BMC Surgery, 2022
Background Previous studies have reported the surgical resection (SR) and radiofrequency ablation (RFA) could achieve comparable recurrence-to-death survival (RTDS).
Youwei Wu, Wei Peng, Junyi Shen, Xiaoyun Zhang, Chuan Li, Tianfu Wen   +5 more
doaj   +1 more source

Postliver Transplantation Rhino-Orbital Mucormycosis, an Unexpected Cause of a Downhill Course

Case Reports in Hepatology, 2022
The COVID-19 pandemic has impacted transplantation worldwide in a major way with infections and post-COVID-19 complications contributing to increased mortality and morbidity.
Swapnali Sabhapandit, Mithun Sharma, Anuradha Sekaran, Balachandran Menon, Anand Kulkarni, Soumya TR, Padaki Nagaraja Rao, Duvurr Nageshwar Reddy   +7 more
doaj   +1 more source