Results 1 to 10 of about 520,167 (196)
Natural Products Targeting Liver X Receptors or Farnesoid X Receptor [PDF]
Frontiers in Pharmacology, 2022 Nuclear receptors (NRs) are a superfamily of transcription factors induced by ligands and also function as integrators of hormonal and nutritional signals.
Jianglian She +9 more
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Targeting Liver X Receptors for the Treatment of Non-Alcoholic Fatty Liver Disease [PDF]
Cells, 2023 Non-alcoholic fatty liver disease (NAFLD) refers to a range of conditions in which excess lipids accumulate in the liver, possibly leading to serious hepatic manifestations such as steatohepatitis, fibrosis/cirrhosis and cancer.
Hyejin Kim, Chaewon Park, Tae Hyun Kim
doaj +2 more sources
Liver X receptors and liver physiology. [PDF]
Biochim Biophys Acta Mol Basis Dis, 2021 The liver x receptors LXRα (NR1H3) and LXRβ (NR1H2) are members of the nuclear hormone receptor superfamily of ligand dependent transcription factors that regulate transcription in response to the direct binding of cholesterol derivatives. Studies using genetic knockouts and synthetic ligands have defined the LXRs as important modulators of lipid ...
Russo-Savage L, Schulman IG.
europepmc +3 more sources
Liver X receptors induce antiproliferative effects in basal‐like breast cancer [PDF]
Molecular Oncology, 2023 Liver X receptors (LXRs) are nuclear transcription factors important in the regulation of cholesterol transport, and glucose and fatty acid metabolism. The antiproliferative role of LXRs has been studied in a variety of malignancies and may represent a ...
Mads Haugland Haugen +14 more
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Activation of liver X receptors protects oligodendrocytes in CA3 of stress-induced mice [PDF]
Frontiers in Pharmacology, 2022 Depression is a complex disorder that is associated with various structural abnormalities. Oligodendrocyte (OL) dysfunction is associated with the pathogenesis of depression and the promotion of hippocampal oligodendrocyte maturation and myelination ...
Peilin Zhu +30 more
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Liver X Receptors: Regulators of Cholesterol Metabolism, Inflammation, Autoimmunity, and Cancer [PDF]
Frontiers in Immunology, 2020 The interplay between cellular stress and immune response can be variable and sometimes contradictory. The mechanisms by which stress-activated pathways regulate the inflammatory response to a pathogen, in autoimmunity or during cancer progression remain
Maria Teresa Bilotta +5 more
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Pseudorabies Virus Inhibits Expression of Liver X Receptors to Assist Viral Infection [PDF]
Viruses, 2022 Pseudorabies virus (PRV) is a contagious herpesvirus that causes Aujeszky’s disease and economic losses worldwide. Liver X receptors (LXRs) belong to the nuclear receptor superfamily and are critical for the control of lipid homeostasis.
Yi Wang +11 more
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Liver X receptors and immune regulation
Biomolecular Concepts, 2010 Recent studies suggest that homeostasis of lipid metabolism is crucial for the function of various immune cells. Oxygenated derivatives of cholesterol (oxysterols) are well-known regulators of lipid metabolism and have diverse functions, such as ...
Nunomura Satoshi +2 more
doaj +3 more sources
Disrupted Lipid Metabolism in Multiple Sclerosis: A Role for Liver X Receptors? [PDF]
Frontiers in Endocrinology, 2021 Multiple sclerosis (MS) is a chronic neurological disease driven by autoimmune, inflammatory and neurodegenerative processes leading to neuronal demyelination and subsequent degeneration.
Inés Pineda-Torra +5 more
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Ligands of Therapeutic Utility for the Liver X Receptors [PDF]
Molecules, 2017 Liver X receptors (LXRs) have been increasingly recognized as a potential therapeutic target to treat pathological conditions ranging from vascular and metabolic diseases, neurological degeneration, to cancers that are driven by lipid metabolism.
Rajesh Komati +5 more
doaj +2 more sources