Adopted orphans as regulators of inflammation, immunity and skeletal homeostasis
Swiss Medical Weekly, 2014 Adopted orphan nuclear receptors, such as peroxisome proliferator-activated receptors (PPARs) and liver X receptors (LXRs), have emerged as key regulators of inflammation and immunity and likewise control skeletal homeostasis.
Natacha Ipseiz +3 more
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Liver X receptor marks the spot [PDF]
Science-Business eXchange, 2014 A New York team and Rgenix have found that LXR agonists can treat metastatic melanoma. The findings open up new therapeutic real estate for LXR agonists that pharma companies discontinued in cardiovascular disease.
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Liver X receptors and estrogen receptor β, two players in a rare subtype of NSCLC. [PDF]
Int J Biol Sci, 2023 Wu W +5 more
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The anti-atherogenic effects of thiazolidinediones [PDF]
, 2007 The thiazolidinediones (TZDs) rosiglitazone (ROS) and pioglitazone (PIO) are insulin-sensitising agents widely used to treat patients with type 2 diabetes mellitus (T2DM). Thiazolidinediones significantly improve glycaemic control in diabetics by reduced
Honisett, Suzy +2 more
core
Canadian Journal of Gastroenterology, 2003 The coordinated effect of lipid activated nuclear hormone receptors; liver X receptor (LXR), bound by oxysterol ligands and farnesoid X receptor (FXR), bound by bile acid ligands, act as genetic transcription factors to cause feed-forward cholesterol ...
Richard N Redinger
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The versatility of liver X receptors in T cell homeostasis: Location, location, location! [PDF]
J Exp Med, 2021 Phan TS, Brunner T.
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Role of liver-X-receptors in airway remodeling in mice with chronic allergic asthma. [PDF]
Exp Ther Med, 2021 Zhang J +7 more
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Liver X receptors regulate natural killer T cell population and antitumor activity in the liver of mice. [PDF]
Sci Rep, 2021 Endo-Umeda K +7 more
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A Network of SLC and ABC Transporter and DME Genes Involved in Remote Sensing and Signaling in the Gut-Liver-Kidney Axis. [PDF]
, 2019 Genes central to drug absorption, distribution, metabolism and elimination (ADME) also regulate numerous endogenous molecules. The Remote Sensing and Signaling Hypothesis argues that an ADME gene-centered network-including SLC and ABC "drug" transporters,
Bush, Kevin T +2 more
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Microwave-Promoted Total Synthesis of Puniceloid D for Modulating the Liver X Receptor
MoleculesA growing global health concern is metabolic syndrome, which is defined by low HDL, diabetes, hypertension, and abdominal obesity. Nuclear receptors are attractive targets for treatment of diseases associated with metabolic syndrome.
Young Jin Jung +5 more
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