Results 91 to 100 of about 524,130 (286)

Siglec receptors impact mammalian lifespan by modulating oxidative stress. [PDF]

, 2015
Aging is a multifactorial process that includes the lifelong accumulation of molecular damage, leading to age-related frailty, disability and disease, and eventually death. In this study, we report evidence of a significant correlation between the number
Fu, Xiaoming, Gagneux, Pascal, Garcia, Javier O, Garcia-Bingman, Andrea, Glass, Christopher K, Hazen, Stanley L, Heyser, Charles, Lin, Hongqiao, Läubli, Heinz, Pearce, Oliver MT, Romanoski, Casey E, Samraj, Annie N, Schwarz, Flavio, Secrest, Patrick, Varki, Ajit, Varki, Nissi, Wang, Xiaoxia   +16 more
core   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

CNS Control of Glucose Metabolism: Response to Environmental Challenges [PDF]

, 2013
Over the last 15 years, considerable work has accumulated to support the role of the CNS in regulating postprandial glucose levels. As discussed in the first section of this review, the CNS receives and integrates information from afferent neurons ...
Arble, Deanna M., Sandoval, Darleen A.
core   +1 more source

Tissue Microenvironments Define and Get Reinforced by Macrophage Phenotypes in Homeostasis or during Inflammation, Repair and Fibrosis [PDF]

, 2012
Current macrophage phenotype classifications are based on distinct in vitro culture conditions that do not adequately mirror complex tissue environments.
Allam R, Allen JE, Anders HJ, Anders HJ, Anders HJ, Anders HJ, Anders HJ, Anders HJ, Andersson-Sjoland A, Arnold L, Atabai K, Barczyk K, Barron L, Bedke J, Belperio JA, Belperio JA, Benoit M, Bertalan R, Blease K, Bonventre JV, Bonventre JV, Broekema M, Burdick MD, Cao Q, Cardenas H, Castano AP, Chorro L, Chow A, Cowin AJ, Crispe IN, Dehmel S, Drake TA, Duffield JS, Duffield JS, Ehninger A, Eis V, El Chartouni C, Fallowfield JA, Fang Y, Fichtner-Feigl S, Filardy AA, Forbes SJ, Galli SJ, Ghielli M, Gordon S, Grgic I, Gurtner GC, Hans-Joachim Anders, Harty MW, Haudek SB, Hayasaki T, Hayashidani S, Hayashidani S, Herbert DR, Huang XR, Ide M, Ikezumi Y, Ikezumi Y, Imamura M, Iredale JP, Ishida Y, Ishii M, Jiang D, Jiang W, John R, Jose MD, Kapsenberg ML, Karlmark KR, Kawai T, King IL, Kisseleva T, Kitagawa K, Kluth DC, Kono H, Krausgruber T, Kulkarni O, Kulkarni O, Lassen S, Lech M, Lech M, Lee S, Lee SB, Leibovich SJ, Leonardo CC, Leor J, Lin SL, Liu G, Lu TT, Lucas M, Lucas T, MacDonald TT, Mantovani A, Marc Weidenbusch, Marra F, Martin P, Martinez FO, Matzinger P, Matzinger P, Medzhitov R, Meisel SR, Messier-Solek C, Mildner A, Mirza R, Mitchell C, Mori L, Mori R, Morimoto H, Mosser DM, Mowat AM, Nahrendorf M, Negishi H, Nelson PJ, Niedermeier M, Ninichuk V, Ninichuk V, Ninichuk V, Nishida M, Occleston NL, Okuma T, Oliphant CJ, Otogawa K, Patole PS, Patole PS, Patole PS, Pawar RD, Pawar RD, Pesce JT, Pilling D, Popov Y, Quan TE, Raghavendra V, Raivich G, Rakoff-Nahoum S, Rapalino O, Rast JP, Ren F, Rock KL, Rock KL, Ryu M, Sakai N, Sathe P, Satoh T, Savill J, Savill J, Schmidt M, Scholten D, Segawa M, Seki E, Semple JW, Shechter R, Shi J, Sindrilaru A, Singer AJ, Smith PD, Sorokin L, Spataro L, Stefater, Swaminathan S, Takeuchi O, Thomas JA, Tian DS, Tian DS, Tokuda A, van Amerongen MJ, van Amerongen MJ, Vielhauer V, Vielhauer V, Wada T, Wada T, Wang Y, Wang Y, Wang Y, Welzen-Coppens JM, Xing Z, Yang L, Yang L, Yang Z, Zeisberg M, Zeisberg M, Zeisberg M, Zheng D, Ziv Y   +181 more
core   +1 more source

Farnesoid X Receptor and Liver X Receptor Ligands Initiate Formation of Coated Platelets [PDF]

Arteriosclerosis, Thrombosis, and Vascular Biology, 2017
Objectives— The liver X receptors (LXRs) and farnesoid X receptor (FXR) have been identified in human platelets. Ligands of these receptors have been shown to have nongenomic inhibitory effects on platelet activation by platelet agonists.
Unsworth, AJ, Bye, AP, Tannetta, DS, Desborough, MJR, Kriek, N, Sage, T, Allan, HE, Crescente, M, Yaqoob, P, Warner, TD, Jones, CI, Gibbins, JM   +11 more
openaire   +5 more sources

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

The Ly49E receptor inhibits the immune control of acute Trypanosoma cruzi infection [PDF]

, 2016
The protozoan parasite Trypanosoma cruzi circulates in the blood upon infection and invades various cells. Parasites intensively multiply during the acute phase of infection and persist lifelong at low levels in tissues and blood during the chronic phase.
Almeida, Andrade, Antunez, Aune, Avilan, Bern, Cardillo, Carlier, Carnaud, Cesari, Collins, Culbertson, Dowling, Duthie, Duthie, Duthie, Filtjens, Fraser, Frosch, Gritz, Hanke, Keating, Lieke, Lieke, Mekkawy, Meyer Zum Buschenfelde, Mondino, Nagata, Nogueira, Pettengill, Pinazo, Rassi, Robertson, Rottenberg, Santana, Sardinha, Stevenaert, Taveirne, Torrico, Truyens, Truyens, Truyens, Une, Van Beneden, Van Beneden, Van Den Broeck, Van Den Broeck, Vassalli, Wen   +48 more
core   +2 more sources

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Regulation of macrophage function in inflammation and atherosclerosis

Journal of Lipid Research, 2009
Atherosclerosis can be considered as both a chronic inflammatory disease and a lipid metabolism disorder. Innate immunity pathways have long been suspected to contribute to the initiation and progression of atherosclerosis.
Norihito Shibata, Christopher K. Glass
doaj   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source