Results 11 to 20 of about 520,167 (196)
Liver X Receptors and Male (In)fertility. [PDF]
Int J Mol Sci, 2019 Liver X receptors (LXRs) are ligand-dependent transcription factors acting as ‘cholesterol sensors’ to regulate lipid homeostasis in cells. The two isoforms, LXRα (NR1H3) and LXRβ (NR1H2), are differentially expressed, with the former expressed predominantly in metabolically active tissues and the latter more ubiquitously.
Jarvis S, Williamson C, Bevan CL.
europepmc +6 more sources
Liver X receptors as regulators of metabolism
Biomolecular Concepts, 2015 The liver X receptors (LXR) are crucial regulators of metabolism. After ligand binding, they regulate gene transcription and thereby mediate changes in metabolic pathways.
Korach-André Marion +1 more
doaj +3 more sources
Vitamin D and lumisterol derivatives can act on liver X receptors (LXRs) [PDF]
Scientific Reports, 2021 The interactions of derivatives of lumisterol (L3) and vitamin D3 (D3) with liver X receptors (LXRs) were investigated. Molecular docking using crystal structures of the ligand binding domains (LBDs) of LXRα and β revealed high docking scores for L3 and ...
Andrzej T. Slominski +18 more
doaj +2 more sources
Liver X receptors: A therapeutic target in demyelinating disorders
Pharmacological ResearchLiver X Receptors (LXRα and LXRβ) are nuclear receptors that regulate various metabolic processes via transcriptional regulation, including lipid and cholesterol homeostasis.
Jule Richartz +7 more
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Cholesterol-sensing liver X receptors stimulate Th2-driven allergic eosinophilic asthma in mice. [PDF]
Immun Inflamm Dis, 2016 Introduction: Liver X receptors (LXRs) are nuclear receptors that function as cholesterol sensors and regulate cholesterol homeostasis. High cholesterol has been recognized as a risk factor in asthma; however, the mechanism of this linkage is not known.
Smet M +10 more
europepmc +3 more sources
Liver X Receptors and Inflammatory-Induced C/EBPβ Selectively Cooperate to Control CD38 Transcription [PDF]
Journal of Innate ImmunityIntroduction: Macrophages abundantly express liver X receptors (LXRs), which are ligand-dependent transcription factors and sensors of several cholesterol metabolites.
Estibaliz Glaría +11 more
doaj +2 more sources
Liver X receptors activation, through TO901317 binding, reduces neuroinflammation in Parkinson's disease. [PDF]
PLoS ONE, 2017 Parkinson's disease (PD) is a neurodegenerative disease in which degeneration of nigrostriatal neurons and inflammation are key players. The aim of our study was to analyze the function of LXRs in neurodegenerative diseases as PD using in vivo, ex vivo ...
Irene Paterniti +8 more
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Cellular and Molecular Gastroenterology and Hepatology, 2021 Nonalcoholic fatty liver disease comprises a wide spectrum of liver injuries from simple steatosis to steatohepatitis and cirrhosis. Nonalcoholic steatohepatitis (NASH) is defined when liver steatosis is associated with inflammation, hepatocyte damage ...
Marica Cariello +2 more
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Bile Acid Receptor Therapeutics Effects on Chronic Liver Diseases [PDF]
, 2020 In the past ten years, our understanding of the importance of bile acids has expanded from fat absorption and glucose/lipid/energy homeostasis into potential therapeutic targets for amelioration of chronic cholestatic liver diseases.
Alpini, Gianfranco +4 more
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Using nuclear receptor activity to stratify hepatocarcinogens. [PDF]
PLoS ONE, 2011 BackgroundNuclear receptors (NR) are a superfamily of ligand-activated transcription factors that control a range of cellular processes. Persistent stimulation of some NR is a non-genotoxic mechanism of rodent liver cancer with unclear relevance to ...
Imran Shah +7 more
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