Cell-specific discrimination of desmosterol and desmosterol mimetics confers selective regulation of LXR and SREBP in macrophages. [PDF]
, 2018 Activation of liver X receptors (LXRs) with synthetic agonists promotes reverse cholesterol transport and protects against atherosclerosis in mouse models.
Bahadorani, John +16 more
core +1 more source
Immune and Inflammatory Pathways in Non-Alcoholic Steatohepatitis (NASH). An update [PDF]
, 2019 Non-alcoholic steatohepatitis (NASH), also known as fatty liver disease (FLD), is a major public health problem. It is considered to be the hepatic manifestation of the metabolic syndrome.
Breaban, Iulia +10 more
core +1 more source
Regulation of macrophage function in inflammation and atherosclerosis
Journal of Lipid Research, 2009 Atherosclerosis can be considered as both a chronic inflammatory disease and a lipid metabolism disorder. Innate immunity pathways have long been suspected to contribute to the initiation and progression of atherosclerosis.
Norihito Shibata, Christopher K. Glass
doaj +1 more source
Endocannabinoid receptor blockade increases hepatocyte growth factor and reduces insulin levels in obese women with polycystic ovary syndrome [PDF]
, 2016 There is evidence from animal and in-vitro studies that activation of the endocannabinoid system (EC) through cannabinoid receptor 1 (CB-1) is associated with liver injury, inflammation and hepatocellular carcinoma.1 Data suggests endogenous cannabinoids
Ahmed, Lina +6 more
core +2 more sources
Altered density of glomerular binding sites for atrial natriuretic factor in bile duct-ligated rats with ascites [PDF]
, 1991 The renal response to atrial natriuretic factor is blunted in cirrhosis with ascites. This might be due to alterations of renal receptors for atrial natriuretic factor.
Almeida +31 more
core +1 more source
Liver X receptors are regulators of adipocyte gene expression but not differentiation
Journal of Lipid Research, 2004 The liver X receptors α and β (LXRα and LXRβ) have been shown to play important roles in lipid homeostasis in liver and macrophages, however, their function in adipose tissue is not well defined.
Sarah Hummasti +7 more
doaj +1 more source
Involvement of leukotriene pathway in the pathogenesis of ischemia-reperfusion injury and septic and non-septic shock. [PDF]
, 2009 The 5-lipoxygenase (5-LO) pathway is responsible for the production of leukotrienes (LTs), inflammatory lipid mediators which play a role in innate immunity. More recently, a pivotal role of LTs in ischemia-reperfusion and shock injury has been suggested.
CUZZOCREA S +2 more
core +1 more source
Liver X Receptor (LXR) Regulates Human Adipocyte Lipolysis [PDF]
Journal of Biological Chemistry, 2011 The Liver X receptor (LXR) is an important regulator of carbohydrate and lipid metabolism in humans and mice. We have recently shown that activation of LXR regulates cellular fuel utilization in adipocytes. In contrast, the role of LXR in human adipocyte lipolysis, the major function of human white fat cells, is not clear.
Stenson, B. M. +13 more
openaire +2 more sources
Siglec receptors impact mammalian lifespan by modulating oxidative stress. [PDF]
, 2015 Aging is a multifactorial process that includes the lifelong accumulation of molecular damage, leading to age-related frailty, disability and disease, and eventually death. In this study, we report evidence of a significant correlation between the number
Fu, Xiaoming +16 more
core +1 more source
The Ly49E receptor inhibits the immune control of acute Trypanosoma cruzi infection [PDF]
, 2016 The protozoan parasite Trypanosoma cruzi circulates in the blood upon infection and invades various cells. Parasites intensively multiply during the acute phase of infection and persist lifelong at low levels in tissues and blood during the chronic phase.
Almeida +48 more
core +2 more sources